Interstitial cells of Cajal as targets for pharmacological intervention in gastrointestinal motor disorders

Huizinga, Jan D.; Thuneberg, Lars; Vanderwinden, Jean‐Marie; Rumessen, Jüri Johannes

doi:10.1016/s0165-6147(97)01108-5

Cited by 173 publications

(124 citation statements)

References 66 publications

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“…The most depolarized phase of the oscillations may not yet pass the threshold; this may need additional stimuli to further depolarize the musculature. 29 Distinct ICC networks have omnipresent myogenic pacemaking activity such as the ICC-MP of the stomach and small intestine. The dog colon is also unambiguous; its omnipresent myogenic activity is in the ICC associated with the submuscular plexus (ICC-SMP).…”

Section: Discussionmentioning

confidence: 99%

Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon

Chen

Yang

et al. 2016

J Neurogastroenterol Motil

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Background/AimsNeurotensin is a gut-brain peptide with both inhibitory and excitatory actions on the colonic musculature; our objective was to understand the implications of this for motor patterns occurring in the intact colon of the rat. MethodsThe effects of neurotensin with concentrations ranging from 0.1-100 nM were studied in the intact rat colon in vitro, by investigating spatio-temporal maps created from video recordings of colonic motility before and after neurotensin. ResultsLow concentration of neurotensin (0.1-1 nM) inhibited propagating long distance contractions and rhythmic propagating motor complexes; in its place a slow propagating rhythmic segmental motor pattern developed. The neurotensin receptor 1 antagonist SR-48692 prevented the development of the segmental motor pattern. Higher concentrations of neurotensin (10 nM and 100 nM) were capable of restoring long distance contraction activity and inhibiting the segmental activity. The slow propagating segmental contraction showed a rhythmic contraction --relaxation cycle at the slow wave frequency originating from the interstitial cells of Cajal associated with the myenteric plexus pacemaker. High concentrations given without prior additions of low concentrations did not evoke the segmental motor pattern. These actions occurred when neurotensin was given in the bath solution or intraluminally. The segmental motor pattern evoked by neurotensin was inhibited by the neural conduction blocker lidocaine. ConclusionsNeurotensin (0.1-1 nM) inhibits the dominant propulsive motor patterns of the colon and a distinct motor pattern of rhythmic slow propagating segmental contractions develops. This motor pattern has the hallmarks of haustral boundary contractions. (J Neurogastroenterol Motil 2016;22:517-528)

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Section: Discussionmentioning

confidence: 99%

Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon

Chen

Yang

et al. 2016

J Neurogastroenterol Motil

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“…These include decreased ICC density, loss of processes and damaged intracellular cytoskeleton and organelles as revealed by immunohistochemical analysis and electron microscopy [33][34][35][36][37] . As a result, it has been proposed that the impairment of the major functional subclasses of ICC (i.e.…”

Section: Enteric Mesenchymopathiesmentioning

confidence: 99%

Chronic intestinal pseudo-obstruction

Antonucci¹,

Fronzoni²,

Cogliandro³

et al. 2008

WJG

190

238

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“…Different ICC populations were found in the gut muscle coat with regionspecific location and region-specific ultrastructural features. Since then, functional studies have brought much light into the physiological importance of these cells in the gut [10][11][12][13]. These studies were aided by the discovery that in the gut ICC express the c-kit receptor [14], and this allowed their recognition at the light microscopy level throughout the intestinal muscle wall.…”

mentioning

confidence: 99%

About the presence of interstitial cells of Cajal outside the musculature of the gastrointestinal tract

Huizinga¹,

Faussone–Pellegrini²

2005

J Cellular Mol Med

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Santiago Ramon y Cajal observed a special cell type that appeared to function as endstructures of the intrinsic nervous system in several organs. These cells were structurally and functionally further characterized in the gut musculature and named interstitial cells of Cajal (ICC). In recent years, interstitial cells have been identified in the vasculature, urinary tract, glands and other organs. Their morphologies and functions are just beginning to be clarified. It is likely that amongst them, subtypes will be discovered that warrant the classification of interstitial cells of Cajal. This “point of view” continues the discussion on the criteria that should be used to identify ICC outside the musculature of the gut.

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Interstitial cells of Cajal as targets for pharmacological intervention in gastrointestinal motor disorders

Cited by 173 publications

References 66 publications

Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon

Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon

Chronic intestinal pseudo-obstruction

About the presence of interstitial cells of Cajal outside the musculature of the gastrointestinal tract

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