Interstitial radiotherapy with 198AU seeds in the primary management of carcinoma of the oral tongue: Results in freiburg/breisgau from January 1964 to July 1980

Slanina, J; Wannenmacher, M; Kuphal, K; Knüfermann, H.; Beck, Chl.; Schilli, W

doi:10.1016/0360-3016(82)90287-5

Cited by 16 publications

(5 citation statements)

References 7 publications

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“…Thirty years ago, Slanina et al reported their experience using 189 Au grains in 32 patients with Stage I–III tongue cancer [ 12 ]. However, the mean age of their subjects was 61 years, which was 10 years younger than that of our study.…”

Section: Discussionmentioning

confidence: 99%

198Au grain implantation for early tongue cancer in patients of advanced age or poor performance status

Ryu¹,

Shibuya²,

Hayashi³

2013

Journal of Radiation Research

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Brachytherapy using 198Au grains is minimally invasive and the only curative treatment for early tongue cancer in patients of advanced age or poor performance status available in our institution. From March 1993 to February 2008, 198Au grains were used to treat a group of 96 Stage I–II tongue cancer patients who could not undergo surgery or brachytherapy using 192Ir pins because of an advanced age (≥75 years) or poor performance status (≥2). The patients were followed for 3.9 ± 3.3 years, and the cause-specific survival and local control rates were determined. Survival analyses were performed using the Kaplan-Meier method, and univariate and multivariate analyses were performed using the Cox proportional hazard model. The results were compared with those for a group of 193 early tongue-cancer patients who underwent treatment using iridium pins. The 5-year cause-specific survival and local control rates of the 198Au grains group were 71% and 68%, respectively, both of which were 16% lower than the corresponding rates for the 192Ir pins group. Our study demonstrated that as the last curative treatment available, 198Au grain implantation could be used to achieve moderate treatment results for early tongue cancer in patients of advanced age or poor performance status.

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Section: Discussionmentioning

confidence: 99%

198Au grain implantation for early tongue cancer in patients of advanced age or poor performance status

Ryu¹,

Shibuya²,

Hayashi³

2013

Journal of Radiation Research

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“…In previous reports on 198 Au brachytherapy for tongue cancer, the two-year CSS rate was 73%, the three-year CSS rate was 73% with T1 and T2, and the five-year CSS rates were 71% and 75% for patients with oral cancer [ 2 , 5 , 19 ]. The three-year OS rate was 57%, and the five-year OS rates were 51% and 52% for patients with oral cancer [ 2 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

Treatment outcomes of real-time intraoral sonography-guided implantation technique of 198Au grain brachytherapy for T1 and T2 tongue cancer

Konishi

Fujita

Takeuchi

et al. 2021

Journal of Radiation Research

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It is often challenging to determine the accurate size and shape of oral lesions through computed tomography (CT) or magnetic resonance imaging (MRI) when they are very small or obscured by metallic artifacts, such as dental prostheses. Intraoral ultrasonography (IUS) has been shown to be beneficial in obtaining precise information about total tumor extension, as well as the exact location and guiding the insertion of catheters during interstitial brachytherapy. We evaluated the role of IUS in assessing the clinical outcomes of interstitial brachytherapy with 198Au grains in tongue cancer through a retrospective medical chart review. The data from 45 patients with T1 (n = 21) and T2 (n = 24) tongue cancer, who were mainly treated with 198Au grain implants between January 2005 and April 2019, were included in this study. 198Au grain implantations were carried out, and positioning of the implants was confirmed by IUS, to ensure that 198Au grains were appropriately placed for the deep border of the tongue lesion. The five-year local control rates of T1 and T2 tongue cancers were 95.2% and 95.5%, respectively. We propose that the use of IUS to identify the extent of lesions and the position of implanted grains is effective when performing brachytherapy with 198Au grains.

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“…Due to the short half-life, the source allows permanent implantations and no removal, resulting in reduced risk of anesthesia and accompanied pain. The radiation exposure of this method of implantation is relatively low and acceptable for treatment staff (14 Á/16), although rotation of treating personnel is recommended to minimize radiation exposure to individuals (14). Despite these advantages, use of gold seed brachytherapy has been limited to areas in the oral cavity and selected patients with oral carcinomas.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with carcinoma of the tongue constituted only 13% (6/45) (16) and 18.6% (33/177) (15) of all patients who underwent gold seed implantation in previous studies. Although a technique was reported for a volume implantation (14), gold seeds were usually used with single plane implantation and were suggested to be a contraindication for deeply invasive carcinomas. This would probably be due to the technical problems involved with implantation and the subsequent occurrence of inadequate dose distributions.…”

Section: Discussionmentioning

confidence: 99%

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Stage I and II Mobile Tongue Carcinomas Treated by External Radiation and Gold Seed Implantation

et al. 2003

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Interstitial radiotherapy with 198AU seeds in the primary management of carcinoma of the oral tongue: Results in freiburg/breisgau from January 1964 to July 1980

Cited by 16 publications

References 7 publications

198Au grain implantation for early tongue cancer in patients of advanced age or poor performance status

198Au grain implantation for early tongue cancer in patients of advanced age or poor performance status

Treatment outcomes of real-time intraoral sonography-guided implantation technique of 198Au grain brachytherapy for T1 and T2 tongue cancer

Stage I and II Mobile Tongue Carcinomas Treated by External Radiation and Gold Seed Implantation

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