Intervention in anaphylaxis: the experience of one paediatric centre based on NORA reports

Tarczoń, Izabela; Jedynak-Wąsowicz, Urszula; Lis, Grzegorz; Tomasik, Tomasz; Brzyski, Piotr; Cichocka‐Jarosz, Ewa

doi:10.5114/ada.2019.89715

Cited by 3 publications

(2 citation statements)

References 31 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The work was supported by Jagiellonian University Medical College work funds (K/ZDS/006266). The presented study was a follow-up of a single-centre analysis, which was previously created in cooperation with the European Anaphylaxis Registry [ 12 ].…”

Section: Methodsmentioning

confidence: 99%

Is the clinical manifestation of anaphylaxis in children influenced by the trigger of reaction?

Tarczoń¹,

Jedynak-Wąsowicz

Lis

et al. 2021

pdia

Self Cite

View full text Add to dashboard Cite

Introduction The number of anaphylaxis diagnoses in children is rising, being still based on the clinical picture. Aim To determine whether triggers of anaphylaxis influence its clinical characteristics in children and adolescents. Material and methods The study group included 114 children (5 months–17 years, mean age: 8.0 ±4.8 years), (66%: boys) with the episode of anaphylaxis up to 1 year back. Medical data were entered to the NORA Registry by means of a validated structured on-line questionnaire. Results Three most frequent triggers of anaphylaxis were: insect venom (47.4%), food (35.1%), drugs (5.3%), with a predominance of food (egg white, cow’s milk, nuts and peanuts) in the 0–6 years age group, while insect venom (bee predominance) in the 7–17 years age group ( p = 0.016). Clinical manifestations differed between food vs. venom allergic reactions and presented as gastro-intestinal (GI) (61.4%) ( p = 0.004), respiratory (RS) (93.9%) ( p = 0.036), and cardiovascular (CVS) (74.6%) ( p = 0.022) symptoms. Among objective symptoms, vomiting was the most common symptom in the 0–2 years age group (47.1%) ( p = 0.006), while hypotension in those aged 7–12 years (40%) ( p = 0.010). Severity of symptoms evaluated as Mueller’s grade (IV – 74.5%) and as Ring and Messmer’s grade (III – 65.8%), depended on the trigger ( p = 0.028, p = 0.029, respectively). Life-threatening symptoms occurred in 26 children (fall of the blood pressure – 22%, loss of consciousness – 4.4%). Conclusions The clinical manifestation of anaphylaxis in children is both trigger and age dependent, irrespective of the gender. A typical patient with food anaphylaxis was younger, presenting predominantly GI symptoms, while a typical patient with venom anaphylaxis was older, with mostly cardiovascular symptoms.

show abstract

Section: Methodsmentioning

confidence: 99%

Is the clinical manifestation of anaphylaxis in children influenced by the trigger of reaction?

Tarczoń¹,

Jedynak-Wąsowicz

Lis

et al. 2021

pdia

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the latest European systematic literature review of 50 studies that included a total of 18,449 participants, adrenaline was verified to be the only disease-modifying intervention in anaphylaxis [ 56 ]. Unfortunately, both medical personnel and parents hesitate to use adrenaline as the primary intervention in anaphylaxis in children despite their prior training and data showing a reduced risk of hospitalization, including the risk of stay in the ICU after pre-hospital adrenaline injection [ 57 , 58 ]. Introduction of new modified autoinjectors might improve the above statistics because they can facilitate appropriate adrenaline administration.…”

Section: Treatment and Preventionmentioning

confidence: 99%

The 2020 update on anaphylaxis in paediatric population

Tarczoń¹,

Cichocka‐Jarosz²,

Knapp³

et al. 2022

pdia

Self Cite

View full text Add to dashboard Cite

The objective of the review is to present recent updates on anaphylaxis in paediatric population worldwide. The article summarizes the results of epidemiological studies, diagnostic methods and treatments. We present a new WAO definition of anaphylaxis (2019), which broader criteria excluding dermal symptoms should facilitate faster lifesaving adrenaline use. Adrenaline remains the best treatment to manage severe symptoms and to prevent biphasic reactions. There is ongoing effort to increase adrenaline use, such as modified autoinjectors, individual training, and diversified dosing. There are five independent risk factors of lethal anaphylaxis in children, including history of asthma, almost immediate onset of symptoms, unwell appearance, tachycardia and hypotension. We also report improvements in diagnostics, like component-resolved diagnostics, and novel therapies stimulating immunotolerance. We signal the development of ICD-11 with updated coding of anaphylaxis, which corresponds better to clinical observations.

show abstract

Causes and clinical symptoms of anaphylactic reactions in children: implementation into clinical practice of the first Pediatric Moscow Anaphylaxis Registry in the Russian Federation

Pampura,

Esakova,

Zimin

et al. 2024

Russian Journal of Allergy

View full text Add to dashboard Cite

BACKGROUND: In Russian, there was a problem of the lack of registry of anaphylaxis, as the most important tool for monitoring this group of patients. Since 2022, the first "Pediatric Moscow Anaphylaxis Registry" has started working at the Morozov Children's Hospital. AIMS: Analysis of data from the Pediatric Moscow Anaphylaxis Registry to determine frequency, causes andclinical characteristics of anaphylaxis among children of the Moscow region. MATERIALS AND METHODS: Statistical analysis of the questionnaire data of 69 children aged 0-18, who were prospectively included in the Register during emergency hospitalization due to anaphylaxis, was carried out. RESULTS: The incidence of anaphylaxis among children hospitalized with acute allergic reactions from May 2022 to September 2023 was 5.8%. Higher percentage of anaphylaxis (38%) were observed among adolescents aged 13-18, three patients developed anaphylaxis in the first year of life (minimum age 1 month). Boys (70%) prevailed among patients under the age of 13, and girls (56%) prevailed among adolescents aged 13-18 (p=0.042). 75% anaphylaxis developed at home. Food anaphylaxis was dominant (75%-91%). Tree nuts were the most common trigger of food anaphylaxis – 35%, and confectionery products - 17%. 56% of children experienced symptoms from 4 or more organ systems, the most common symptoms were: skin/mucous (94%), respiratory (78%) and laryngeal symptoms (64%). Emergency care, diagnosed anaphylaxis in 22%, administration of epinephrine was 54%. The frequency of epinephrine use among children under 3 years was lower compared to adolescents aged 13-18 (25% vs 76%, p=0.003). CONCLUSIONS:Data from the "Pediatric Moscow Register of Anaphylaxis" showed a high incidence of anaphylaxis among patients with acute allergic reactions. More than 1/3 of anaphylaxis occurs in adolescents aged 13-18 years, anaphylaxis occurs in the first month of life. Most often, anaphylaxis occurs at home, which requires training patients to eliminate the trigger. The dominant cause of anaphylaxis in children in the Russian, regardless of age, are food allergens, tree nuts induce food anaphylaxis in more than 1/3 of cases. The emergency care diagnoses anaphylaxis in 22% of cases, epinephrine is administered in 54%, minimal use of epinephrine was among children under 3 years of age.

show abstract

Intervention in anaphylaxis: the experience of one paediatric centre based on NORA reports

Cited by 3 publications

References 31 publications

Is the clinical manifestation of anaphylaxis in children influenced by the trigger of reaction?

Is the clinical manifestation of anaphylaxis in children influenced by the trigger of reaction?

The 2020 update on anaphylaxis in paediatric population

Causes and clinical symptoms of anaphylactic reactions in children: implementation into clinical practice of the first Pediatric Moscow Anaphylaxis Registry in the Russian Federation

Contact Info

Product

Resources

About