Intestinal iron absorption in chickens

Marti, M. T.; Sáiz, M. P.; Mitjavila, M. T.; Planas, Jordi

doi:10.1007/bf02783824

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…Blood iron indices of plasma iron, total iron binding capacity and transferrin iron saturation values were higher in the chickens than in the mynahs. The plasma iron levels were lower in mynahs but were similar to previous reports on mynahs (Mete et al, 2001), starlings (Garcia et al, 1984) and chickens (Marti et al, 1980;Sanchez & Planas, 1981), whereas feeding with higher quantities of iron had no influence. Biochemical analysis of the liver iron content showed much higher values for the mynahs, the difference being at least 10-fold.…”

Section: Discussionsupporting

confidence: 89%

“…The present data revealed similar apparent transporter affinity (K m ) for both species but a three-fold higher limiting uptake rate (V max ) in mynah bird enterocytes, implying that the number of the transporter is increased. Earlier data in intestinal segments of chickens were obtained from Fe(III) uptake, much higher concentrations were used, and saturation was not observed (Marti et al, 1980;Sanchez & Planas, 1981). Since conditions may have been less than physiological, the results are not comparable.…”

Section: Discussionmentioning

confidence: 99%

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Iron metabolism in mynah birds (Gracula religiosa)resembles human hereditary haemochromatosis

et al. 2003

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Iron overload is a very frequent finding in several animal species and a genetic predisposition is suggested. In one of the most commonly reported species with susceptibility for iron overload (mynah bird), it was recently shown that the cause of this pathophysiology is high uptake and retention of dietary iron. Here we compare susceptible (mynahs) with non-susceptible avian species (chickens) by evaluating iron uptake at the intestinal absorptive cell level. Enterocytes from mynahs and chickens were isolated and uptake of Fe(II) and Fe(III) was studied in vitro. It was found that Fe(III) uptake is much lower than Fe(II) uptake for both species. Although liver iron, present only in hepatocytes, was at least 10-fold higher in mynahs than chickens, enterocyte Fe(II) uptake was considerably higher in mynahs. Fe(II) uptake showed saturation at the studied concentrations in both species. Kinetic studies revealed a three-fold increase in Vmax for mynahs. Calculated values for the uptake kinetics of the probable membrane transporter suggest that mynah bird enterocytes have a significantly higher limiting uptake rate, due to the possible increase in the number of transporters when compared with chicken enterocytes. The susceptibility of this species is due to intestinal iron uptake despite hepatic iron accumulation, implicating a 'mis-sensing' of body iron similarly to human hereditary haemochromatosis.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Iron metabolism in mynah birds (Gracula religiosa)resembles human hereditary haemochromatosis

et al. 2003

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Iron absorption by small intestine of chickens

Sáiz

Marti

Mitjavila

et al. 1993

Biol Trace Elem Res

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Iron (Fe) absorption by three segments (duodenum, jejunum, and ileum) of the small intestine of chickens was studied by a perfusion technique in vivo in closed circuit using 59Fe Cl3 and was related to the histological characteristics of each segment. The serosal transfers of Fe for the duodenum and jejunum were the same (14%/cm), but significantly different (p < 0.05) from those of the ileum (9%/cm), which may be explained by the morphological and histological properties of the gut of chickens. However, the presence of Fe in blood and in liver was significantly lower after perfusion of the jejunum and ileum than after perfusion of the duodenum. It is concluded that chickens show an early adaptation of small intestine to Fe absorption in response to the considerable loss of Fe suffered during the laying process.

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Intestinal iron absorption in chickens

Sáiz

Marti²,

Mitjavila³

et al. 1980

Biol Trace Elem Res

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Sexual differences in intestinal iron absorption in Shaver and New Hampshire chickens strains was analyzed with an in vivo perfusion technique in closed circuit. In 6-week-old Shaver chickens, a significantly higher rate was found in females.A comparison of the absorption rates between adult males and laying and nonlaying hens from the New Hampshire strain, showed a significant increase of the net transfer during the laying period. However, we did not find any differences between males and nonlaying hens. From our data, a thicker intestinal wall seemed evident in the adult females, with highest values during laying.Estrogen administration in male chickens increased the plasma iron and produced a defensive reaction to iron absorption. However, during the laying stage, high plasma levels were found to be tied to higher absorption rates.Iron storage in females is higher in proportion to the increase of iron absorption, which is enhanced during the laying period. Estrogen appears to mediate this process, but from present data the point of action has not yet been identified.

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Intestinal iron absorption in chickens

Cited by 5 publications

References 28 publications

Iron metabolism in mynah birds (Gracula religiosa)resembles human hereditary haemochromatosis

Iron metabolism in mynah birds (Gracula religiosa)resembles human hereditary haemochromatosis

Iron absorption by small intestine of chickens

Intestinal iron absorption in chickens

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