Intestinal myoelectric activity in response to live Vibrio cholerae and cholera enterotoxin.

Mathias, John R.; Carlson, Gerald M.; DiMarino, A J; Bertiger, Gerald; Morton, H. E.; Cohen, Sidney

doi:10.1172/jci108464

Cited by 104 publications

(46 citation statements)

References 23 publications

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“…2 C). This organized activity was similar to the MAPC activity caused by cholera toxin (15). The propagation velocity of these MAPC was faster than the MAPC reported for cholera toxin and often occurred simultaneously on all recording sites.…”

Section: Resultssupporting

confidence: 80%

“…In a series of recent animal studies, we have shown that specific pathogenic bacteria or their enterotoxins alter the motor function of the small intestine (15)(16)(17)(18)(19). Myoelectric recording techniques were used for all studies.…”

Section: Introductionmentioning

confidence: 99%

“…The specific alterations in myoelectric activity that were observed correlated with the clinical characteristics of the infectious agent studied. Noninvasive bacteria or their enterotoxins, which are associated clinically with profuse diarrhea and minimal abdominal pain, induced a propulsive motor pattern called the migrating action potential complex (MAPC) (15,16). Invasive bacteria or their cytotoxins, which produced illness characterized by moderate to severe pain and less diarrheal output, induced a less propulsive motor complex called repetitive bursts of action potentials (RBAP) (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

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Altered myoelectric activity in the experimental blind loop syndrome.

Justus¹,

Fernández²,

Martin³

et al. 1983

J. Clin. Invest.

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A B S T R A C T Nutrient malabsorption and diarrhea are characteristic of the blind loop syndrome. Alterations in motility have been implicated as a cause of bacterial overgrowth, but the possibility that altered motility may result from alterations in the flora has not been explored. The purpose of this study was to characterize the myoelectric activity of the small intestine in the blind loop rat model. Eight groups of rats were studied: rats with self-filling blind loops, which develop bacterial overgrowth; rats with selfemptying blind loops, which are surgical controls that do not develop overgrowth; unoperated litter mates; rats with self-filling blind loops and unoperated controls treated with chloramphenicol, 200 mg/d i.p.; rats with surgically removed self-filling blind loops; operated control rats; and gnotobiotic rats with self-filling blind loops. In the untreated rats with self-filling blind loops, there was altered myoelectric activity characterized by an increased percentage of slow waves occupied by action potentials and by organized activity similar to the migrating action potential complex. Migrating action potential complex activity and percentage of slow waves occupied by action potentials were significantly decreased with chloramphenicol therapy; that decrease correlated with a decrease in aerobes and anaerobes. Migrating action potential complex activity was abolished in rats with surgically removed self-filling blind loops; they also showed a significant decrease in percentage of slow waves occupied by action potentials. Gnotobiotic rats with self-

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Section: Resultssupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Altered myoelectric activity in the experimental blind loop syndrome.

Justus¹,

Fernández²,

Martin³

et al. 1983

J. Clin. Invest.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our concern was that an active motility component existed but may have occurred beyond the reported 2-h period. We have previously demonstrated that an abnormal myoelectric pattern developed in terminal ileal loops of the New Zealand white rabbit when exposed to cholera enterotoxin (12). In addition, we have reported that a lag period existed before the onset of MAPC activity to cholera enterotoxin (3.8 h) and to prostaglandin F2a (3.2 h) (13).…”

Section: Discussionmentioning

confidence: 97%

“…We have recently reported that an alteration in myoelectric activity developed in the small intestine of New Zealand white rabbits when exposed to cholera enterotoxin (12,13). This alteration in myoelectric activity was defined as the migratinig action potential complex (MAPC).…”

Section: Introductionmentioning

confidence: 99%