Intra- and subretinal neovascularization following radiation therapy: Contribution of OCT-angiography

Mathis, Thibaud; Levron, Antoine; Pommier, P.; Denis, Philippe; Thariat, Juliette; Kodjikian, Laurent

doi:10.1016/j.jfo.2018.04.007

Cited by 4 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The disease is characterized by telangiectasia, microaneurysms, hard exudates, hemorrhages, and edema in the irradiated retina. Aberrant retinal neovascularization represents the end stage of the disease and can be complicated by intraocular hemorrhage and tractional retinal detachment [ 37 ]. When the surface of the ischemic retina is large, neovessels can also develop on the iris margin and in the trabecular meshwork leading to neovascular glaucoma (NVG).…”

Section: Ocular Side-effects Of Radiotherapy Involving the Eye Or Orbitmentioning

confidence: 99%

Non-Cancer Effects following Ionizing Irradiation Involving the Eye and Orbit

Thariat

Martel

Matet

et al. 2022

Cancers

View full text Add to dashboard Cite

The eye is an exemplarily challenging organ to treat when considering ocular tumors. It is at the crossroads of several major aims in oncology: tumor control, organ preservation, and functional outcomes including vision and quality of life. The proximity between the tumor and organs that are susceptible to radiation damage explain these challenges. Given a high enough dose of radiation, virtually any cancer will be destroyed with radiotherapy. Yet, the doses inevitably absorbed by normal tissues may lead to complications, the likelihood of which increases with the radiation dose and volume of normal tissues irradiated. Precision radiotherapy allows personalized decision-making algorithms based on patient and tumor characteristics by exploiting the full knowledge of the physics, radiobiology, and the modifications made to the radiotherapy equipment to adapt to the various ocular tumors. Anticipation of the spectrum and severity of radiation-induced complications is crucial to the decision of which technique to use for a given tumor. Radiation can damage the lacrimal gland, eyelashes/eyelids, cornea, lens, macula/retina, optic nerves and chiasma, each having specific dose–response characteristics. The present review is a report of non-cancer effects that may occur following ionizing irradiation involving the eye and orbit and their specific patterns of toxicity for a given radiotherapy modality.

show abstract

Section: Ocular Side-effects Of Radiotherapy Involving the Eye Or Orbitmentioning

confidence: 99%