2004
DOI: 10.1007/s00011-004-1273-1
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Intra-articular treatment of arthritis with microsphere formulations of paclitaxel: biocompatibility and efficacy determinations in rabbits

Abstract: Paclitaxel-loaded PLA microspheres in the 35-105 microm size range, released paclitaxel in a controlled manner over several weeks, and may be a potential formulation for the intra-articular treatment of inflammation in arthritic conditions.

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Cited by 83 publications
(54 citation statements)
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“…Some studies, however, showed beneficial effects of IA administration of paclitaxel and methotrexate without apparent toxicity and side effects in an animal model [61,62]. In line with other classes of drugs there is potential for cytostatic drugs when administered via an intra-articular drug delivery system [61].…”
Section: Cytostatic Drugsmentioning
confidence: 99%
See 1 more Smart Citation
“…Some studies, however, showed beneficial effects of IA administration of paclitaxel and methotrexate without apparent toxicity and side effects in an animal model [61,62]. In line with other classes of drugs there is potential for cytostatic drugs when administered via an intra-articular drug delivery system [61].…”
Section: Cytostatic Drugsmentioning
confidence: 99%
“…PLA has been shown to be biocompatible in rabbit knees [61,62], polyethylene glycol (PEG), often combined with other polymers (e.g., polycaprolactone (PCL)) is biocompatible and able to control release characteristics of the incorporated drug [72][73][74][75], however, by far, the most used synthetic polymer is PLGA. This synthetic polymer has a good biocompatibility and is able to incorporate many different types of drugs [29,31,[35][36][37]39,[42][43][44][45][46]50,60,61,[72][73][74][76][77][78][79][80][81][82][83][84]. Several studies have been published on the incorporation of proteins in different DDSs, a common problem in the classical models (e.g., PLGA), however, is the initial burst release, which can cause local toxic drug concentrations, and the acidic breakdown products can influence protein stability followed by a very slow or no release at all [68,85,86].…”
Section: Polymersmentioning
confidence: 99%
“…These potentially deleterious effects have, as yet, not been thoroughly investigated. A recent efficacy study for drug delivery using PLA microspheres in the 35-105 micron size range, loaded with 20% Paclitaxel, a chemotherapeutical agent resulted in Paclitaxel release in a controlled manner over several weeks in a rabbit model [178]. Thus local drug delivery approach using PLA scaffold may be a potential formulation for the intra-articular treatment of inflammation in arthritic conditions.…”
Section: Scaffoldsmentioning
confidence: 99%
“…This tissular reaction could have resulted from a number of factors other than particle size, such as microparticle concentration in the articulation, polymer type or even particle shape. Concerning particle shape, Liggins et al showed that irregular, milled chitosan particles induced joint inflammation despite the known articular biocompatibility of this biomaterial [13]. Because irregularly shaped microparticles are known to promote inflammation in diverse tissues, round-shaped microspheres are preferable for intra-articular delivery.…”
Section: Introductionmentioning
confidence: 99%