Intra-articular Versus Intravenous Tranexamic Acid in Primary Total Knee Replacement

Ahmad, Fayyaz; Hafeez, Sohail; Khan, Fahim Ullah; Orakzai, Sajjad H; Nur, Aamer Nabi; Khan, Muhammad Ali

doi:10.7759/cureus.21052

Cited by 1 publication

(2 citation statements)

References 22 publications

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“…Finally, several studies included the association of intravenous and intra-articular administration of TXA, with good outcomes without any increase in thromboembolic risk [12,26,42].…”

Section: Tranexamic Acidmentioning

confidence: 99%

See 1 more Smart Citation

Optimised fast‐track protocols in total knee arthroplasty determine shorter hospitalisation time and lower perioperative/postoperative complications

Compagnoni,

Puglia,

Magnani

et al. 2024

Knee surg. sports traumatol. arthrosc.

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PurposeThis literature review aims to present evidence‐based clinical recommendations for the eight most debated topics related to perioperative management in total knee arthroplasty: counselling, prehabilitation, transfusion risk, tranexamic acid, drainage, analgesia, urinary catheter and compression stockings.MethodsA multidisciplinary team conducted a systematic review on these topics. The study followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines for the literature review and result presentation. The research encompassed articles from 1 January 2009 to 28 February 2023, retrieved through the MEDLINE database via PubMed, Embase database and Cochrane Library.ResultsForty‐five articles were selected. Preoperative counselling has limited evidence for its impact on postoperative outcomes; yet, it can help alleviate surgery‐related anxiety and manage postoperative symptoms. Prehabilitation can also prepare patients for surgery, reducing hospital stays and improving postsurgery functionality. Numerous studies suggest that preoperative Hb levels are independently linked to transfusion risk, with a recommended level of 13 g/dL. Combining intravenous and local tranexamic acid administration is strongly advised to reduce perioperative blood loss, while drainage after primary total knee arthroplasty offers no functional advantages. Employing a multimodal analgesia approach yields better results with reduced opioid usage. Indwelling urinary catheters provide no benefit and avoiding them can lower the risk of urinary tract infections. As for compression stockings, there is insufficient evidence in the literature to support their efficacy in preventing venous thromboembolism.ConclusionThe best‐track protocol has demonstrated its efficacy in reducing hospitalisation time and perioperative/postoperative complications. It is success relies on a collaborative, resource‐adaptive approach led by a multidisciplinary team. Both patients and hospitals benefit from this approach, as it enhances care quality and lowers costs. Several studies have highlighted the significance of a patient‐centred approach in achieving high‐quality care. Creating a novel treatment protocol could be a prospective goal in the near future.Level of EvidenceLevel III.

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“…Finally, several studies included the association of intravenous and intra-articular administration of TXA, with good outcomes without any increase in thromboembolic risk [12,26,42].…”

Section: Tranexamic Acidmentioning

confidence: 99%

“…Several studies have concluded that the reduction in perioperative and intraoperative blood loss is statistically significant for both intravenous and local administration compared with the group that did not receive TXA [12,20,24,26,28,42].…”

Section: Tranexamic Acidmentioning

confidence: 99%