Intra‐oral salivary gland neoplasms: a retrospective study of 98 cases

Chau, M. N. Y.; Radden, B. G.

doi:10.1111/j.1600-0714.1986.tb00636.x

Cited by 58 publications

(51 citation statements)

References 13 publications

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“…Our figure of 66% is higher than the series in the United States (Spiro et al 1973;Chaudhry et al 1984 ;Regezi et al 1985) but appears to be almost the same as in Australia (Chau and Radden 1986) (Table 6). …”

Section: Discussioncontrasting

confidence: 62%

Intraoral minor salivary gland tumors: A demographic and histologic study of 200 cases.

Takahashi

Fujita

Tsuda

et al. 1990

Tohoku J. Exp. Med.

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In a demographic and histologic study of 200 intraoral minor salivary gland tumors seen in Japan (Nagasaki and Miyagi prefectures), 127 cases (63.5%) were classified as benign, comprising 124 pleomorphic adenomas and 3 monomorphic adenomas. The other 73 cases (36.5%) were malignant tumors, represented by 33 adenoid cystic carcinomas, 16 mucoepidermoid carcinomas, 10 carcinoma in pleomorphic adenomas, 6 acinic cell carcinomas, 5 adenocarcinomas, one polymorphous low-grade adenocarcinoma, one undifferentiated carcinoma and one clear cell carcinoma. There was an overall female preponderance (1.78/1). The mean age for females was 47.2 years and for males was 50.6 years. The mean age for patients with malignant tumors was 10 years greater than for patients with benign tumors and was statistically significant. The palate was the most common site for intraoral minor salivary gland tumors followed by the lip and buccal mucosa. These three sites accounted for 83° of all cases. Tumors arising in these three sites were predominantly benign. In contrast, those located in the gingiva, floor of the mouth and tongue were predominantly malignant. The results of this study were compared with other recent studies.-minor salivary gland ; tumors ; histology ; age and sex ; Japanese Neoplasms of minor salivary gland origin occur much less commonly than those arising from major salivary glands (Gorlin and Chaudhry 1957;Richardson et al. 1975;Main et al. 1976;Shrikhande and Talvalker 1978;DelBalso 1979;Perzin and LiVolsi 1979;Brocheriou et al. 1980;Eveson and Cawson 1985b). In spite of their relative infrequency in terms of the total number of cases accessioned in most oral or hospital surgical pathology services (Regezi et al.

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Section: Discussioncontrasting

confidence: 62%

Intraoral minor salivary gland tumors: A demographic and histologic study of 200 cases.

Takahashi

Fujita

Tsuda

et al. 1990

Tohoku J. Exp. Med.

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“…The findings are in agreement with those of several studies that have pointed a percentage of PA of benign minor salivary gland neoplasms very close to 75% found in the present study 1,2,[9][10][11][12][13][14][15][16] . In addition, of the 18 cases found in this study, 10 occurred in the palate, demonstrating its high incidence in this location, as supported by several authors 9,11,12,15 .…”

Section: Discussionsupporting

confidence: 94%

“…In addition to these, the literature presents other possible signs and symptoms such as radiographic changes, ulcers, difficulty with normal oral functions and misfitting dentures 5,10,14,15 . The fact that the lesion had developed during an average period of 9.6 months before being recognized, and reached an average size of 2.1 cm, can be explained by its the silent nature of its growth 2,15 .…”

Section: Discussionmentioning

confidence: 99%

Surgical approach to pleomorphic adenomas arising in the palate

Soares¹,

Costa²,

Bezerra³

et al. 2016

J Oral Diag

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AbstrAct:Salivary gland tumors represent an important group of neoplasms characterized by a great diversity of types and morphological variants. Pleomorphic adenoma is the most common benign tumor occurring in the major and minor salivary glands. The majority of case series described in the literature refers to epidemiological data of major and minor salivary gland tumors, generally being of a benign or malignant nature. Studies reporting exclusively surgical treatment experience with pleomorphic adenomas of the palate are scarce. Therefore, the aim of this study was to report data on the treatment experience with surgical removal of pleomorphic adenoma of the palate together with to nearby mucosal lining with or without ostectomy. Clinical records of all patients diagnosed with pleomorphic adenoma of the palate seen at Brazilian public service dental clinic (Oral and Maxillofacial Surgery Division) and at a private clinic between March 1999 and November 2010 were reviewed. The analysis of the biopsied specimens yielded 10 cases during the 10-year period. Of all the patients 8 were women, with mean age 39 years. The most common main complaint was asymptomatic increase in volume (n = 9), with mean tumor size 2.1 cm. Most patients (n = 8) underwent excision of tumor and mucosal lining. One patient underwent bone ostectomy and in another, the tumor regressed after incisional biopsy. The mean follow--up was 26,8 months (12-42 months) with no recurrences, and the main complication was local discomfort and dysphonia (n = 2). In summary, surgical excision of the tumor and mucosal lining, with or without ostectomy, was shown to be an effective treatment modality for pleomorphic adenomas of the palate.

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“…Periodic acid Schiff (PAS) with and without diastase, A review of publications in English (MEDLINE 1966-2014) was performed, with all cases reported with clinical, histologic, immunophenotypic and/or follow-up information on CanAd evaluated and included in the review, but excluding ''Quiz'' or ''Case of the Month'' type reports. Several studies were excluded if no specific or separable information was given about CanAd or if the illustrations were not characteristic [23,51,55,[59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78]. Several of the cases seemed to have been included multiple times in different series reports [9,10,40,[79][80][81][82][83].…”

Section: Methodsmentioning

confidence: 99%

Canalicular Adenoma: A Clinicopathologic and Immunohistochemical Analysis of 67 Cases with a Review of the Literature

Thompson

Bauer

Chiosea

et al. 2014

Head and Neck Pathol

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There is a lack of a comprehensive immunohistochemical (IHC) analysis of canalicular adenoma (CanAd), especially when combined with a description of the unique histologic features. Given the usual small biopsies, IHC may be useful in distinguishing CanAd from other tumors in the differential diagnosis. Retrospective. The patients included 54 females and 13 males (4.2:1), aged 43-90 years, with a mean age at presentation of 69.9 years. Clinical presentation was generally a mass (n = 61) slowly increasing in size (mean 38.5 months), affecting the upper lip (n = 46), buccal mucosa (n = 17) or palate (n = 4), involving the right (n = 29), left (n = 24) or midline (n = 9), without any major salivary gland tumors. The tumors ranged in size from 0.2 to 3 cm (mean 1.2 cm). Most tumors were multilobular or bosselated (76 %), often surrounded by a capsule. Histologically, the tumors were characterized by cystic spaces, tumor cords with beading, tubule formation, and by the presence of luminal squamous balls (n = 41). The cells were cuboidal to columnar with stippled chromatin. Mitoses were inconspicuous. A myxoid stroma (n = 64), sclerosis (n = 42), luminal hemorrhage (n = 51), and luminal microliths (calcifications) (n = 33) were characteristic. Nine (13.4 %) were multifocal. CanAd showed the following characteristic immunohistochemistry findings: CK-pan and S100 protein (strong, diffuse reaction); peripheral or luminal GFAP reaction; CK5/6 and p16 luminal squamous ball reaction; SOX10 nuclear reaction; cytoplasmic p63 reaction. CanAd are unique minor salivary gland tumors showing a distinct architecture and phenotype. They predilect to older women, with the majority multilobulated and affecting the upper lip, multifocal in 13 %; no major salivary gland tumors were identified. S100 protein, CK-pan, GFAP and SOX10 are positive, with luminal squamous balls highlighted by CK5/6 or p16.

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Intra‐oral salivary gland neoplasms: a retrospective study of 98 cases

Cited by 58 publications

References 13 publications

Intraoral minor salivary gland tumors: A demographic and histologic study of 200 cases.

Intraoral minor salivary gland tumors: A demographic and histologic study of 200 cases.

Surgical approach to pleomorphic adenomas arising in the palate

Canalicular Adenoma: A Clinicopathologic and Immunohistochemical Analysis of 67 Cases with a Review of the Literature

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