Intraarterial yttrium 90 in the treatment of hepatic malignancy.

Mantravadi, Rao V.P.; Spigos, Dimitrios G.; Tan, Woei; Felix, Edward L.

doi:10.1148/radiology.142.3.7063703

Cited by 142 publications

(52 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Calculated from the area of the peak ascribed to the phosphorus, it is confirmed that about 60% of the implanted phosphorus remained in the sample even after the soaking. 4. Discussion Figure 2 showed that the amount of the phosphorus ion implanted into the silica glass is saturated at a dose of 5 1017cm-2 under 50keV.…”

mentioning

confidence: 91%

Properties of Silica Glass Implanted with Phosphorus Ion at 50keV for Radiotherapy

Kawashita

Miyaji

Takaoka

et al. 1996

J. Ceram. Soc. Japan

View full text Add to dashboard Cite

A chemically durable glass containing a large amount of phosphorus is useful for in situ irradiation of can cers. It can be activated to emitter with 14.3d half-life by neutron bombardment. Microspheres of the acti vated glass injected to the tumors can irradiate ray directly to the tumors without giving radiation to neighboring normal tissues. In order to examine possibility for obtaining such a glass by ion implantation, P+ ion was implanted into a pure silica glass in a plate form under 50keV to different doses. This implanta tion energy is estimated to give the maximum concentration of P+ ion at 48.6nm in depth from the surface. Structural damage was produced near the surface of the glass by the ion implantation for all the doses in the range from 51016 to 1101cm-2.The phosphorus was localized only in the regions deeper than 1.2nm from the surface, taking a form of phosphorus colloids, for a dose of 51016cm2, whereas it was distribut ed up to the glass surface and a part of it near the surface was oxidized for doses above 11017cm2. The former glass little released both P and Si into water at 95 even after 7d, whereas the latter glasses released appreciable amounts of these elements. At implantation energy of 20keV, even a dose of 51016 cm-2 formed an oxidized phosphorus at the glass surface and gave appreciable releases of P and Si from the glass into water. This indicates that a chemically durable glass containing a larger amount of phosphorus could be obtained if P+ ion is implanted at higher energies and localized in a deeper region, even if the sur face structure of the glass is damaged by the ion implantation.

show abstract

mentioning

confidence: 91%

Properties of Silica Glass Implanted with Phosphorus Ion at 50keV for Radiotherapy

Kawashita

Miyaji

Takaoka

et al. 1996

J. Ceram. Soc. Japan

View full text Add to dashboard Cite

show abstract

“…First patient series with intravenous application had poor outcomes [7]. Starting from the late 1970s, initial clinical series on nonselective intra-arterial 90 Y RE administered in the proper hepatic artery reported promising results, and it was observed that hypervascularized tumors were more likely to benefit from this type of therapy [8]. Several doseescalation studies in animals and humans followed these early reports [9], with an initial study indicating an excellent safety profile if angiographic findings and extrahepatic shunting were assessed before treatment [10].…”

Section: History Ofmentioning

confidence: 99%

Standards of Practice in Transarterial Radioembolization

Mahnken

Spreafico

Maleux

et al. 2013

Cardiovasc Intervent Radiol

View full text Add to dashboard Cite

“…The favorable results of 90 Y-microsphere RE treatment in different animal models led to the clinical development of this technique in the 1970s. The first clinical investigations [11][12][13][14] were conducted in the 1980s in selected patients and they gave encouraging results. However, the release of free isotope into the circulation due to leaking of 90 Y from the microspheres caused severe pancytopenia in several patients.…”

Section: Yttrium-90 Microspheresmentioning

confidence: 99%

Multiagent imaging of liver tumors with reference to intra-arterial radioembolization

Maccauro¹,

Lorenzoni²,

Boni

et al. 2013

Clin Transl Imaging

View full text Add to dashboard Cite

Intra-arterial radioembolization using microspheres labeled with the high-energy beta-emitter yttrium-90 ( 90 Y) is an innovative therapeutic strategy for primary and secondary hepatic malignancies. An accurate imaging workup plays a pivotal role in correctly selecting patients for treatment, to avoid severe complications and in assessment of the post-administration microsphere distribution. Nuclear medicine imaging modalities are an integral part of a complex multidisciplinary approach. In particular, hepatic perfusion imaging with 99m Tc-macroaggregated albumin particles ( 99m Tc-MAA), which identifies extrahepatic accumulation of radiopharmaceutical and lung shunt, is necessary to correctly select patients who may benefit from the treatment. Furthermore, 99m Tc MAA SPECT-based dose planning may optimize RE efficacy, overcoming the limitations of empirical methods to determine the activity to be administered. Quantitative assessment of the post-administration intrahepatic microsphere distribution with SPECT or PET is important for evaluation of toxicity and efficacy and can be used for the prediction of patient response and for patient-specific therapeutic dose optimization. Finally, [ 18 F]FDG PET/CT imaging is important in the assessment of early response after RE and in predicting patient outcome. This review provides a comprehensive overview of multimodality imaging in the complex management of patients undergoing RE for liver tumors.

show abstract

Intraarterial yttrium 90 in the treatment of hepatic malignancy.

Cited by 142 publications

References 0 publications

Properties of Silica Glass Implanted with Phosphorus Ion at 50keV for Radiotherapy

Properties of Silica Glass Implanted with Phosphorus Ion at 50keV for Radiotherapy

Standards of Practice in Transarterial Radioembolization

Multiagent imaging of liver tumors with reference to intra-arterial radioembolization

Contact Info

Product

Resources

About