2019
DOI: 10.1016/j.actbio.2019.06.005
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Intracameral injection of a chemically cross-linked hydrogel to study chronic neurodegeneration in glaucoma

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Cited by 31 publications
(25 citation statements)
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References 48 publications
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“…The IOP elevation of the model was stable and sustained even with only 1 injection, and this will help reduce possibilities of infection and also provide sufficient time window for studying pathological changes in this chronic disease. Therefore, cross-linked hydrogels have seen increased use in the construction of glaucoma models in recent years [ 14 , 15 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The IOP elevation of the model was stable and sustained even with only 1 injection, and this will help reduce possibilities of infection and also provide sufficient time window for studying pathological changes in this chronic disease. Therefore, cross-linked hydrogels have seen increased use in the construction of glaucoma models in recent years [ 14 , 15 ].…”
Section: Discussionmentioning
confidence: 99%
“…At present, many methods have been attempted for establishing an animal chronic ocular hypertension (COH) model to reflect the basic characteristics of glaucoma. These include gene mutation [ 2 – 4 ], laser photocoagulation on the aqueous humor outflow pathway [ 5 ], injection of hypertonic saline into the episcleral vein [ 6 , 7 ], cauterization or ligation of episcleral veins [ 8 , 9 ], infusion of microbeads into the anterior chamber [ 10 , 11 ], and injection of hyaluronic acid [ 12 , 13 ] or cross-linked hydrogel [ 14 , 15 ] into the anterior chamber. Although these methods can to some extent simulate the glaucomatous optic neuropathy caused by chronic high intraocular pressure (IOP), their evaluation is still limited to increased IOP and loss of RGCs.…”
Section: Introductionmentioning
confidence: 99%
“…23 Thus, the long reaction duration provides multiple opportunities to manufacture hydrogel scaffolds with particular specifications, allowing in situ gelling via local injection, in vitro gel casting, and three-dimensional printing. 24,25 Collectively, optimal biomaterials with sufficient mechanical property for skeletal tissue regeneration are urgently needed. And the crosslinking capability of genipin has a great potential in tissue engineering.…”
Section: Introductionmentioning
confidence: 99%
“… 23 Thus, the long reaction duration provides multiple opportunities to manufacture hydrogel scaffolds with particular specifications, allowing in situ gelling via local injection, in vitro gel casting, and three-dimensional printing. 24 , 25 …”
Section: Introductionmentioning
confidence: 99%
“…Over the past decade, seminal works from Calkins’ and Sponsel’s groups demonstrate that the central nervous system controls glaucomatous neurodegeneration in both humans and murine models in the early stages 48 . Recent neuroimaging research also demonstrates the occurrence of changes in a number of brain structures in glaucoma, both within and outside visual processing areas 917 . However, current literature on glaucoma neuroimaging remains sparse and incomplete, and is mostly limited to studies with small sample sizes and toward advanced disease stages 18 .…”
Section: Introductionmentioning
confidence: 99%