Intracanal calcification following regenerative endodontic treatment: a systematic review and meta-analysis

Almutairi, Waleed; Al-Dahman, Yousef; Alnassar, Faisal; Albalawi, Olayan

doi:10.1007/s00784-021-04333-5

Cited by 10 publications

(5 citation statements)

References 41 publications

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“…It was reported that root canal calcification occurred more frequently in cases treated with calcium hydroxide paste than in those medicated with antibiotic pastes. 2,18 In the present study, the incidence of calcification of teeth medicated with calcium hydroxide paste was 86% (50/58), c Nolla stage of root development. 11 which was significantly than that of teeth treated with antibiotic paste (11/18, 61%) or teeth using combined application methods (10/15, 67%).…”

Section: Discussionsupporting

confidence: 47%

Evaluation of the characteristics of root canal calcification after regenerative endodontic procedures: A retrospective cohort study over 3 years

Jiang

Dai

2022

Int J Paed Dentistry

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Aim This study aimed to evaluate the characteristics of root canal calcification after regenerative endodontic procedures (REPs) during long‐term follow‐up. Design Data of children who underwent REPs and were followed up for >3 years in the Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, China, from January 2013 to January 2019, were collected. All the patients were treated by the protocol of REPs based on the American Association of Endodontists (AAE) protocol. A total of 91 teeth of 54 boys and 37 girls (average age 10.4 ± 1.9 years) with follow‐up duration >3 years were included. The follow‐up duration ranged from 36 to 92 months (average, 53.2 ± 13.4 months). The prevalence, contributing factors, and long‐term prognoses of root canal calcification after REPs are discussed. Independent t‐test and χ2 test were used for statistical analysis. Results The incidence of root canal calcification was 78% (71/91). The use of calcium hydroxide paste was significantly correlated with the occurrence of root canal calcification (p < .05). Some teeth showed aggravation of calcification with time; however, not all teeth showed calcification after longer follow‐up duration. Conclusions Teeth treated with REPs had a relatively high probability of root canal calcification detection during the long‐term follow‐up. The occurrence of calcification is related to the use of calcium hydroxide paste but does not affect the long‐term prognosis of teeth.

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Section: Discussionsupporting

confidence: 47%

Evaluation of the characteristics of root canal calcification after regenerative endodontic procedures: A retrospective cohort study over 3 years

Jiang

Dai

2022

Int J Paed Dentistry

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“…Ca(OH) 2 has been recommended as an intracanal medication for VPT and REPs ( Hermann, 1920 , Galler et al, 2016 , Almutairi et al, 2022 ) because of its various advantages. The main actions of Ca(OH) 2 come from the ionic dissociation of Ca 2+ and OH – ions.…”

Section: Discussionmentioning

confidence: 99%

The viability of human dental pulp cells and apical papilla cells after treatment with conventional calcium hydroxide and nanoparticulate calcium hydroxide at various concentrations

Pugdee,

Klaisiri,

Phumpatrakom

2023

The Saudi Dental Journal

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“…Distinct from adult teeth, the open apical foramen and fragile root canal wall complicate clinical intervention. Prior studies consistently report suboptimal outcomes, including recurrent periapical lesions, halted root formation, and intracanal obliteration [35][36][37]. Seeking and optimizing current strategies to preserve immature AP teeth remains a crucial clinical focus.…”

Section: Discussionmentioning

confidence: 99%

FTO Positively Regulates Odontoblastic Differentiation via SMOC2 in Human Stem Cells from the Apical Papilla under Inflammatory Microenvironment

Huang,

Sun,

Huang

et al. 2024

IJMS

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Odontoblastic differentiation of human stem cells from the apical papilla (hSCAPs) is crucial for continued root development and dentin formation in immature teeth with apical periodontitis (AP). Fat mass and obesity-associated protein (FTO) has been reported to regulate bone regeneration and osteogenic differentiation profoundly. However, the effect of FTO on hSCAPs remains unknown. This study aimed to identify the potential function of FTO in hSCAPs’ odontoblastic differentiation under normal and inflammatory conditions and to investigate its underlying mechanism preliminarily. Histological staining and micro-computed tomography were used to evaluate root development and FTO expression in SD rats with induced AP. The odontoblastic differentiation ability of hSCAPs was assessed via alkaline phosphatase and alizarin red S staining, qRT-PCR, and Western blotting. Gain- and loss-of-function assays and online bioinformatics tools were conducted to explore the function of FTO and its potential mechanism in modulating hSCAPs differentiation. Significantly downregulated FTO expression and root developmental defects were observed in rats with AP. FTO expression notably increased during in vitro odontoblastic differentiation of hSCAPs, while lipopolysaccharide (LPS) inhibited FTO expression and odontoblastic differentiation. Knockdown of FTO impaired odontoblastic differentiation, whereas FTO overexpression alleviated the inhibitory effects of LPS on differentiation. Furthermore, FTO promoted the expression of secreted modular calcium-binding protein 2 (SMOC2), and the knockdown of SMOC2 in hSCAPs partially attenuated the promotion of odontoblastic differentiation mediated by FTO overexpression under LPS-induced inflammation. This study revealed that FTO positively regulates the odontoblastic differentiation ability of hSCAPs by promoting SMOC2 expression. Furthermore, LPS-induced inflammation compromises the odontoblastic differentiation of hSCAPs by downregulating FTO, highlighting the promising role of FTO in regulating hSCAPs differentiation under the inflammatory microenvironment.

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Intracanal calcification following regenerative endodontic treatment: a systematic review and meta-analysis

Cited by 10 publications

References 41 publications

Evaluation of the characteristics of root canal calcification after regenerative endodontic procedures: A retrospective cohort study over 3 years

Evaluation of the characteristics of root canal calcification after regenerative endodontic procedures: A retrospective cohort study over 3 years

The viability of human dental pulp cells and apical papilla cells after treatment with conventional calcium hydroxide and nanoparticulate calcium hydroxide at various concentrations

FTO Positively Regulates Odontoblastic Differentiation via SMOC2 in Human Stem Cells from the Apical Papilla under Inflammatory Microenvironment

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