Intracellular free calcium concentration and thromboxane A₂formation of vascular smooth muscle cells are influenced by fish oil and n-3 eicosapentaenoic acid

Abstract

in rat VSMC stimulated by a variety of vasoactive agonist, fish oil and EPA can markedly attenuate intracellular mechanisms related to changes of cytosolic calcium concentration and eicosanoid production.(ABSTRACT TRUNCATED AT 250 WORDS)

Modulation of enzymatic activities by n-3 polyunsaturated fatty acids to support cardiovascular health

“…Furthermore, an increase in cellular Ca 2+ is associated with enhanced cell contraction, vasoconstriction and cell proliferation and, thus, may be involved in the development of cardiovascular diseases [35]. Among various biochemical derangements, the increase in intracellular Ca 2+ plays a permissive role in the development of arrhythmia [36] and cardiac hypertrophy [37].…”

Does the coronary risk factor low density lipoprotein alter growth and signaling in vascular smooth muscle cells?

“…Moreover, LDL increases the gene transcription of c‐fos and egr‐1, which are essential transcription factors for VSMC proliferation (3, 64). Locher et al reported that LDL induces generation of thromboxane A 2 (65), a potent growth‐promoting factor for VSMCs (66). Up‐regulation of the Ang II AT1 receptor by LDL has been observed in VSMCs resulting in an elevation of the functional AT1 receptors and a potentiation of the Ang II‐induced DNA synthesis (41).…”

Fish oils, eicosanoid biosynthesis and cardiovascular disease: An overview

“…EPA can attenuate elevation of intracellular calcium generation in cultured rat aortic vascular smooth muscle cells (Locher et al, 1991). Elevation of intracellular calcium is a central intracellular signalling system by which hormones and growth factors regulate many different processes such as secretion, metabolism, cell growth, differentiation and cell contractility.…”