Intracellular free radical scavenging activity and protective role of mammalian cells by antioxidant peptide from thioredoxin disulfide reductase of Arthrospira platensis

Sannasimuthu, Anbazahan; Arockiaraj, Jesu

doi:10.1016/j.jff.2019.103513

Cited by 26 publications

(17 citation statements)

References 61 publications

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“…As shown in Table 2, the peptide containing histidine and lysine showed better inhibitory activity than another one 53 . It seems that the inhibitory potency is related to the histidine and lysine residues as they have been known to be able to chelate metals 54 …”

Section: Natural Peptidesmentioning

confidence: 93%

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Naturally occurring and synthetic peptides: Efficient tyrosinase inhibitors

Hariri

Saeedi

Akbarzadeh

2021

Journal of Peptide Science

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Tyrosinase is a copper‐containing enzyme involved in the biosynthesis of melanin pigment, which is the most important photo protective agent against skin photo carcinogenesis. Excess production of melanin causes hyperpigmentation leading to undesired browning in human skin, fruits, and vegetable as well as plant‐derived foods. Moreover, the role of tyrosinase in the onset and progression of various diseases such as cancers, Alzheimer's, and Parkinson diseases has been well documented in the literature. In this respect, tyrosinase inhibitors have been in the center of attention particularly as the efficient skin whitening agents. Among a wide range of compounds possessing anti‐tyrosinase activity, peptides both natural and synthetic derivatives have attracted attention due to high potency and safety.

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Section: Natural Peptidesmentioning

confidence: 93%

“…to be able to chelate metals. 54 Liceaga et al studied chia seeds (Salvia hispanica L.) to investigate their effects on enzymes involved in skin aging including tyrosinase.…”

Section: Kawagishia Et Al Drew Out Anti-tyrosinase Cyclotetrapeptide Frommentioning

confidence: 99%

Naturally occurring and synthetic peptides: Efficient tyrosinase inhibitors

Hariri

Saeedi

Akbarzadeh

2021

Journal of Peptide Science

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“…Attack of DNA by ROS produced under conditions of oxidative stress can induce strand breaks, DNA-DNA and DNA-protein crosslinking, and formation of at least 20 modified bases adducts, which play a key role in aging, cancer, arteriosclerosis, neurodegenerative diseases, and diabetes [ 39 , 40 ]. The antioxidant hydrolysate and BPs are stage by stage accepted as food components applied in functional food and nutraceuticals to effectively adjust and control the oxidative injury to protect DNA, lipid, and protein in the human body [ 41 – 43 ]. Hoki frame protein hydrolysate (APHPH) could decrease t-butyl hydroperoxide-caused cytotoxicity on human embryonic lung fibroblasts and observably protect DNA against the free radical-induced injury [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Mechanisms of the Oligopeptides (FWKVV and FMPLH) from Muscle Hydrolysate of Miiuy Croaker against Oxidative Damage of HUVECs

Wang

Pan

et al. 2021

Oxidative Medicine and Cellular Longevity

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In this work, the antioxidant mechanisms of bioactive oligopeptides (FWKVV and FMPLH) from protein hydrolysate of miiuy croaker muscle against H2O2-damaged human umbilical vein endothelial cells (HUVECs) were researched systemically. The finding demonstrated that the HUVEC viability treated with ten antioxidant peptides (M1 to M10) at 100.0 μM for 24 h was not significantly affected compared with that of the normal group ( P < 0.05 ). Furthermore, FWKVV and FMPLH at 100.0 μM could very significantly enhance the viabilities ( 75.89 ± 1.79 % and 70.03 ± 4.37 % ) of oxidative-damaged HUVECs by H2O2 compared with those of the model group ( 51.66 ± 2.48 % ) ( P < 0.001 ). The results indicated that FWKVV and FMPLH played their protective functions through increasing the levels of antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and decreasing the levels of reactive oxygen species (ROS), malondialdehyde (MDA), and nitric oxide (NO) in oxidative-damaged HUVECs in a dose-dependent manner. In addition, the comet assay revealed that FWKVV and FMPLH could dose-dependently protect deoxyribonucleic acid (DNA) from oxidative damage in the HUVEC model. These results suggested that antioxidant pentapeptides (FWKVV and FMPLH) could serve as potential antioxidant additives applied in the food products, pharmaceuticals, and health supplements.

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“…Generation of $OH was carried out through the Fenton reaction by mixing H 2 O 2 and Fe(II) with salicylic acid. 47,48 The reaction system contained 1 mL of 9 mM FeSO 4 and 1 mL of 9 mM salicylic acid dissolved in ethanol and 1 mL of various concentrations of samples. The reaction system was freshly prepared and reacted at 37 C for 30 min prior to the detection of absorbance at 510 nm (A x ).…”

Section: Antioxidant Activity Assaysmentioning

confidence: 99%