Intracochlear pressure measurements to study bone conduction transmission: State-of-the art and proof of concept of the experimental Procedure

Borgers, Charlotte; Wieringen, Astrid Van; D’hondt, Christiane; Verhaert, Nicolas

doi:10.1063/1.5038471

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Intracochlear pressure measurements involve inserting one or two miniature pressure sensors in the cochlear spaces filled with inner ear fluid, specifically in the scala vestibuli and the scala tympani. The differential pressure - i.e., the complex difference between the pressure in both scalae - correlates with the cochlear drive and can thus be used to estimate hearing sensation ( Dancer and Franke, 1980 ; Niesten et al, 2015 ; Borgers et al, 2018 ; Stieger et al, 2018 ; Guan et al, 2020 ). One advantage of this measurement technique is that it encompasses the contributions of all five bone conduction pathways: ear canal compression, middle ear inertia, inner ear compression, inner ear inertia, and transmission via the cerebrospinal fluid ( Stenfelt and Goode, 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Objective preclinical measures for bone conduction implants

Wils,

Geerardyn,

Putzeys

et al. 2024

Front. Neurosci.

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The study evaluates the accuracy of predicting intracochlear pressure during bone conduction stimulation using promontory velocity and ear canal pressure, as less invasive alternatives to intracochlear pressure. Stimulating with a percutaneous bone conduction device implanted in six human cadaveric ears, measurements were taken across various intensities, frequencies, and stimulation positions. Results indicate that intracochlear pressure linearly correlates with ear canal pressure (R2 = 0.43, RMSE = 6.85 dB), and promontory velocity (R2 = 0.47, RMSE = 6.60 dB). Normalizing data to mitigate the influence of stimulation position leads to a substantial improvement in these correlations. R2 values increased substantially to 0.93 for both the ear canal pressure and the promontory velocity, with RMSE reduced considerably to 2.02 (for ear canal pressure) and 1.94 dB (for promontory velocity). Conclusively, both ear canal pressure and promontory velocity showed potential in predicting intracochlear pressure and the prediction accuracy notably enhanced when accounting for stimulation position. Ultimately, these findings advocate for the continued use of intracochlear pressure measurements to evaluate future bone conduction devices and illuminate the role of stimulation position in influencing the dynamics of bone conduction pathways.

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Section: Introductionmentioning

confidence: 99%

Objective preclinical measures for bone conduction implants

Wils,

Geerardyn,

Putzeys

et al. 2024

Front. Neurosci.

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Frequency dependence and harmonic distortion of stapes displacement and intracochlear pressure in response to very high level sounds

Greene,

Argo,

Easter

et al. 2024

Hearing Research

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Lumped element models of sound conduction in the human ear: A systematic review

Wils,

Geerardyn,

Putzeys

et al. 2023

The Journal of the Acoustical Society of America

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Lumped element models facilitate investigating the fundamental mechanisms of human ear sound conduction. This systematic review aims to guide researchers to the optimal model for the investigated parameters. For this purpose, the literature was reviewed up to 12 July 2023, according to the PRISMA guidelines. Seven models are included via database searching, and another 19 via cross-referencing. The quality of the models is assessed by comparing the predicted middle ear transfer function, the tympanic membrane impedance, the energy reflectance, and the intracochlear pressures (ICPs) (scala vestibuli, scala tympani, and differential) with experimental data. Regarding air conduction (AC), the models characterize the pathway from the outer to the inner ear and accurately predict all six aforementioned parameters. This contrasts with the few existing bone conduction (BC) models that simulate only a part of the ear. In addition, these models excel at predicting one observable parameter, namely, ICP. Thus, a model that simulates BC from the coupling site to the inner ear is still lacking and would increase insights into the human ear sound conduction. Last, this review provides insights and recommendations to determine the appropriate model for AC and BC implants, which is highly relevant for future clinical applications.

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Intracochlear pressure measurements to study bone conduction transmission: State-of-the art and proof of concept of the experimental Procedure

Cited by 3 publications

References 14 publications

Objective preclinical measures for bone conduction implants

Objective preclinical measures for bone conduction implants

Frequency dependence and harmonic distortion of stapes displacement and intracochlear pressure in response to very high level sounds

Lumped element models of sound conduction in the human ear: A systematic review

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