Intracranial infection due to mycobacterium bovis in Hodgkin's disease.

Intra-Cranial Lesions in a Patient with Hodgkin Lymphoma

“…Despite the previously documented increased incidence of tuberculosis in HD [6,7] it is extremely rare to find CNS involvement by TB in association with HD. We found only one case of tuberculous meningitis in conjunction with HD but the causative agent in this case was Mycobacterium bovis [8]. In general, the prevalence of TB in patients with malignancy is higher than that of the normal population and is most prevalent in HD patients (96/10,000) [7].…”

Tuberculous meningitis due to Mycobacterium bovis: a report of two cases

“…As far as we can ascertain, there have been only three published cases from Western countries of intracranial M. bovis infection in the last decade and in only one of these was the spinal fluid culture-positive (Traub et al, 1984;Jones & Silva, 1982;Heath & Grant, 1984). In England and Wales from 1975 to 1981 inclusive, only eight CSF isolates of M. bovis were reported to Central Diseases Surveillance Centre and even this may include cases of M. africanum infection which, because of its close laboratory resemblance to M. bovis, is often reported as such (Collins & Grange, 1983).…”

Editorial<subtitle>Tuberculosis – Certainly not a Disease of the Past!</subtitle>

“…In another study at Birmingham, 10 patients with intracranial tuberculomas have been reported over a four-year period (8). These lesions should be searched for even more vigorously in the immunocompromised host (9). The condition carries a high mortality rate if not promptly managed; expansion of the lesion during treatment has been reported (10).…”