Intraepithelial lymphocytes in the jejunal mucosa of malnourished rats.

Maffei, Helga Verena L.; Rodrigues, Maria Aparecida Marchesan; Camargo, Joíza Lins; Campana, Álvaro Oscar

doi:10.1136/gut.21.1.32

Cited by 13 publications

(7 citation statements)

References 12 publications

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“…Significant reductions of serum albumin in rats in the absence of edema were also found with protein-free diet during 28-32 days 5 and during 84 days 6 .…”

Section: Discussionmentioning

confidence: 73%

“…Decreases in the values of total protein were also found in rats fed with protein-free diet 5,6 and with diets containing 0 and 4% protein levels 22 .…”

Section: Discussionmentioning

confidence: 82%

“…In studies in rats it was demonstrated that when fed with a 0.5% protein diet, these animals had a decrease in the plasma levels of albumin and induction of edema 1 . Other authors also found a significant decrease in the albumin levels in rats subjected to desnutrition 5,6 . Experimental desnutrition is a fruitful area for the investigation of neuronal plasticity and the interdependence of neuronal and non-neuronal mechanisms 7 .…”

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confidence: 82%

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Effects of protein and vitamin B deficiency on blood parameters and myenteric neurons of the colon of rats

Sant’Ana

Molinari

Miranda-Neto

2001

Arq. Neuro-Psiquiatr.

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-The aims of this work were to evaluate the effects of the deficient ingestion of protein and vitamin B on the biochemical and hematologic parameters and on the NADH-and NADPH-diaphorase positive myenteric neurons. The control animals (n=10) received commercial chow and the experimental rats (n=10) received chow with protein level reduced to 8% during 120 days. At the time of killing blood was collected for assessment of the blood and hematologic parameters and the ascending colon for quantitative analysis of the neurons of the myenteric plexus. It was observed that the reduction of the protein level to 8% coupled to the reduction of the levels of vitamin B in adult rats neither led to qualitative or quantitative changes on red or white blood cells, nor decreased globulin levels, induced the formation of edema or gave rise to clinical signs typical of protein or vitamin B deficiency. On the other hand, the experimental protocol led to less weight gain, change on the body composition with fat deposition; decrease of the values of serum total protein and albumin; reduction of the area of colon and density of nitrergic and NADH-diaphorase myenteric neurons inferior to the expected.KEY WORDS: enteric neurons, proteic desnutrition, ascending colon, hematology, vitamin B.Efeitos da deficiência de proteínas e vitamina B sobre parâmetros sanguíneos e neurônios mioentéricos do colo de ratos adultos RESUMO -Os objetivos deste trabalho foram avaliar as repercussões da ingestão deficiente de proteínas e vitaminas do complexo B sobre parâmetros bioquímicos e hematológicos e neurônios mientéricos NADH e NADPH-diaforase positivos. Os animais controle (n=10) receberam ração comercial e os animais experimentais (n=10) ração com teor protéico reduzido para 8% durante 120 dias. Durante o sacrifício, coletou-se o sangue dos animais para avaliação de parâmetros sanguíneos e hematológicos e o colo ascendente para a análise quantitativa dos neurônios do plexo mioentérico. Observou-se que a redução do teor de proteínas na dieta para 8% associado a redução no teor de vitaminas do complexo B em ratos adultos, não causa alterações qualitativas e quantitativas das células sanguíneas das séries vermelha e branca, não leva a redução do valor da globulina nem a formação de edema ou ao surgimento de sinais clínicos característicos das carências de proteínas e vitaminas do complexo B. Por outro lado causa: menor ganho de peso corporal; alteração da composição corporal com acúmulo de gordura; redução nos valores de proteína total e albumina; redução na área do colo e evidenciação de densidade de neurônios nitrérgicos e NADH-diaforase positivos inferior ao esperado.PALAVRAS CHAVE: neurônios entéricos, desnutrição protéica, colo ascendente, hematologia, vitamina B. The utilization of animal models in studies of food restriction with known and controlled diets has as an advantage the improved knowledge about the many aspects of the human desnutrition 1 . Research on desnutrition aimsat simulating natural conditions, which involve deficienc...

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“…Significant reductions of serum albumin in rats in the absence of edema were also found with protein-free diet during 28-32 days 5 and during 84 days 6 .…”

Section: Discussionmentioning

confidence: 73%

“…Decreases in the values of total protein were also found in rats fed with protein-free diet 5,6 and with diets containing 0 and 4% protein levels 22 .…”

Section: Discussionmentioning

confidence: 82%

mentioning

confidence: 82%

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Effects of protein and vitamin B deficiency on blood parameters and myenteric neurons of the colon of rats

Sant’Ana

Molinari

Miranda-Neto

2001

Arq. Neuro-Psiquiatr.

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“…Condition Impact References [31] but does not change mucosal protein content [32]. Thus, not only the amount of calories but also the amount of protein influences the gut barrier morphology.…”

Section: Structurementioning

confidence: 96%

Alterations of gut barrier and gut microbiota in food restriction, food deprivation and protein-energy wasting

2015

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“…The consequences of nutritional deficiencies on the intestinal morphology have interested researchers for decades [1][2][3][4][5][6] . Several studies demonstrated morphological alterations such as intestinal atrophy in undernourished animals 1,2,5-8 , regardless of the animals' stage of life 2,3,6 .…”

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confidence: 99%

Effect of protein and vitamin B deficiency on the morpho-quantitative aspects of the myenteric plexus of the descending colon of adult rats

Araújo

Sant’Ana

Molinari

et al. 2003

Arq. Neuro-Psiquiatr.

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We carried out this work with the purpose of studying the effects of protein and vitamin B deficiency on the morphologic and quantitative aspects of the myenteric plexus of the descending colon of adult Rattus norvegicus. Twenty-eight rats were divided in two groups, one of them receiving chow with 22% protein level (control) and the other fed with chow having 8% protein level without vitamin B supplementation, during 120 days. Whole-mounts of the descending colon were prepared and stained with Giemsa, NADH-diaphorase and NADPH-diaphorase. The undernourished rats had a body weight 11.84% less than the control group. Relative to the controls, the experimental group had a colonic area 48% smaller, 51.9% less Giemsa-stained neurons, 28.3% less NADH-diaphorase positive neurons and 24.2% less NADPH-diaphorase positive neurons.

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Intraepithelial lymphocytes in the jejunal mucosa of malnourished rats.

Cited by 13 publications

References 12 publications

Effects of protein and vitamin B deficiency on blood parameters and myenteric neurons of the colon of rats

Effects of protein and vitamin B deficiency on blood parameters and myenteric neurons of the colon of rats

Alterations of gut barrier and gut microbiota in food restriction, food deprivation and protein-energy wasting

Effect of protein and vitamin B deficiency on the morpho-quantitative aspects of the myenteric plexus of the descending colon of adult rats

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