Intralesional bleomycin in the treatment of cutaneous warts: A randomized clinical trial comparing it with cryotherapy

Abstract

IL bleomycin injection was significantly more effective than cryotherapy for treatment of cutaneous wart.

A Two-week Interval Is Better Than a Three-week Interval for Reducing the Recurrence Rate of Hand-foot Viral Warts after Cryotherapy: A Retrospective Review of 560 Hand-foot Viral Warts Patients

“…There are a few reports describing the recurrence rate after cryotherapy, and the results vary widely from 16.7% to 35% 3,4,12,15,17 . In our study, the overall recurrence rate was 19.6%, and the recurrence rate of each subtype of foot only, hand only, and both hands and feet was 12%, 27.3%, and 31.3% respectively (Tables 2, 3).…”

“…There are many studies that compared the efficacy of cryotherapy with other modalities and assessed cure rates for cryotherapy of viral warts (Table 5) 3,4,[8][9][10][11][12][13][14][15][16][17][18][19] . These studies show cure rates ranging from 43% to 83%.…”

“…Two week intervals will favor maintaining the immune response that occurs due to the keratolytic effects of cryotherapy. Among studies designed to find ideal modalities for treating viral warts, immune-associated methods evoke better cure results than cryotherapy 4,[13][14][15] . Additionally, imiquimod and diphenylcyclo-propenone immunotherapy showed quite a lower recurrence rate in the literature.…”

“…Today, there are plenty of therapeutic modalities that are used to treat warts, but there is no single therapy that is 100% effective 3 . Among these modalities, cryotherapy is the preferred method due to safety, convenience of application, and lack of need for anesthesia 1,4 .…”

Bleomycin Chemotherapy for Oral Leukoplakia

“…Off-label use of intralesional bleomycin is another primary and/or adjunctive therapy for different cutaneous lesions dermatology as several types of cutaneous malignancies, telangiectasias, vascular malformations, hemangiomas, and lesions of leishmaniasis cutisand condyloma acuminate (13). Studies have also suggested intralesional bleomycin to be more effective in treatment of warts when compared to surgical modalities like cryotherapy (14). Recent research has revealed that bleomycin is a reliable and safe treatment modality for warts resistant to other therapeutics (15).…”