Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury

Ikumi, Akira; Hara, Yuki; Okano, Eriko; Kohyama, Sho; Arai, Norihito; Taniguchi, Yu; Sugaya, Hisashi; Yoshioka, Tomokazu; Kanamori, Akira; Yamazaki, Masashi

doi:10.1155/2018/1275713

Cited by 10 publications

(9 citation statements)

References 33 publications

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“…Many factors play a role in this nerve regeneration and can be delayed/slowed down. Similarly, studies have shown reports of improved and enhanced nerve regeneration in hand surgeries where PRP was used 13,14. Therefore, incorporation of PRP administration at the time of surgery may have beneficial effects for nerve regeneration as well.…”

Section: Discussionmentioning

confidence: 97%

Effect of hair restoration surgery on the scalp sensitivity

Malik¹,

Mohmand²

2020

J of Cosmetic Dermatology

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Background Hair transplant procedure is a surgical procedure which affects the sensitivity of the scalp. Objectives To compare scalp two‐point discrimination (2PD) values in healthy controls and patients who had hair transplant surgery. Patients/methods The comparative study was conducted in 25 healthy individuals and 25 patient who underwent hair transplant surgery (either strip surgery or FUE). An area was marked o scalp about 10 cm from the nasion. A caliper with 15 g weight was used. Both the prongs were ensured to be placed perpendicular to the skin. The contact time was only 2.0 seconds. An interval of 10 seconds was given before increasing the 2PD distance. In each measurement, the distance was increased by 1 mm. All the data were recorded and analyzed statistically using ANOVA test. Results The mean age of the control group was 29.72 and 31.7 years in patients' group. The average 2PD score in controls was 12.76 and 17.80 mm in patients. The average 2PD score was found to be 17.7 in patients who had surgery less than 18 months ago as compared to the score of 17.6 in patients who had surgery more than 18 months ago (P > .05). The smokers had less sensitivity as compared to the nonsmokers (P < .05). Conclusion The scalp sensitivity was found to be less than 39% in patients after hair transplant surgery.

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Section: Discussionmentioning

confidence: 97%

Effect of hair restoration surgery on the scalp sensitivity

Malik¹,

Mohmand²

2020

J of Cosmetic Dermatology

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“…Improvement of restricted finger ROM was recognized from two weeks postoperatively, and became normal after four weeks after surgery. Neuropathic pain disappeared after 9 months postoperatively [15].Complete healing in case of traumatic injures depends on the patients age (in both cases they were young), on the complications, duration of denervation, time and size of defect (complete neurotmesis of radial nerve, total rehabilitation period, after 5 injection and 14 months, incomplete neurotmesis of digital nerve, 1 injection and 6 months). However, PRP injection has been shown to help reduce neuropathic pain and speed recovery in both cases.…”

Section: Methodsmentioning

confidence: 93%

“…The digital nerves are important in hand function. Affecting them through trauma causes sensory disturbances, hinders delicate movements of the hand such as pinching small objects or hanging buttons [15].…”

Section: Methodsmentioning

confidence: 99%

Platelet-rich plasma in treatment of acute lesions and chronic disease of forearm, wrist and hand

Moldovan¹,

Dogaru²,

Sturza³

2018

Balneo

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The aim of this study is to compare the efficiency of Platelet-rich plasma (PRP) in the treatment of acute lesions and chronical disease of bones, joints and nerves from forearm, wrist and hand. Material and Methods: articles published in English between 2008 and 2018 from medical literature were selected. Results: when it comes to acute lesions three articles were found; one about the using of PRP in distal radius fractures and the two about the infiltration of PRP in the complete neurotmesis of radial nerve or in digital nerve incomplete section. In chronic conditions only one article about trapeziometacarpian (TMC) osteoarthritis (OA) was found, and three articles about a median nerve compression in carpal tunnel syndrome (CTS). Conclusions: 1.The medical literature contains few publications regarding the efficiency of PRP in treatment of traumatic lesions and chronic disease of forearm, wrist and hand. 2. In chronic conditions the favorable outcomes after the PRP injection are obtained only in the first stage of the disease, in advanced stages the surgical treatment is mandatory.

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“…Another recovery burden of nerve repair is scarring, which has been reported to be minimized by PRP as an adjuvant therapy for the repair of injured sciatic nerves 14 . In addition, there were restricted case reports in a clinical study of ultrasound-guided PRP injection for treating common peroneal nerve trauma, digital nerve crush injury and carpal tunnel syndrome [43][44][45] . However, few systematic studies that have simultaneously incorporated both the selection of PRP concentration in vitro and verification of the optimal concentration in vivo have been conducted, and the effects have not been studied using serial ultrasound-guided injection therapy.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-guided platelet-rich plasma injection and multimodality ultrasound examination of peripheral nerve crush injury

et al. 2020

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Ultrasound-guided platelet-rich plasma (PRP) injection is able to make up for the limitations of applying a single growth factor. The goal of this study was to investigate the effects of serial ultrasound-guided PRP injections of the appropriate concentration on the treatment of sciatic nerve crush injury, and explore the value of multimodality ultrasound techniques in evaluating the prognosis of crushed peripheral nerve. In vitro, optimal concentration of PRP (from 150%, 250%, 450%, and 650%) was screened due for its maximal effect on proliferation and neurotrophic function of Schwann cells (SCs). In vivo, ninety rabbits were equally and randomly divided into normal control, model, PRP-2.5×, PRP-4.5×, and PRP-6.5× groups. The neurological function and electrophysiological recovery evaluation, and the comparison of the multimodality ultrasound evaluation with the histological results of sciatic nerve crush injury were performed to investigate the regenerative effects of PRP at different concentrations on the sciatic nerve crush injury. Our results showed that the PRP with a 4.5-fold concentration of whole blood platelets could significantly stimulate the proliferation and secretion of SCs and nerve repair. The changes in stiffness and blood perfusion were positively correlated with the collagen area percentage and VEGF expression in the injured nerve, respectively. Thus, serial ultrasound-guided PRP injections at an appropriate concentration accelerates the recovery of axonal function. Multimodality ultrasound techniques provide a clinical reference for prognosis by allowing the stiffness and microcirculation perfusion of crush-injured peripheral nerves to be quantitatively evaluated.

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Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury

Cited by 10 publications

References 33 publications

Effect of hair restoration surgery on the scalp sensitivity

Effect of hair restoration surgery on the scalp sensitivity

Platelet-rich plasma in treatment of acute lesions and chronic disease of forearm, wrist and hand

Ultrasound-guided platelet-rich plasma injection and multimodality ultrasound examination of peripheral nerve crush injury

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