Intraoperative radiation therapy

Calvo, Felipe A.; Meiriño, R.; Orecchia, Roberto

doi:10.1016/j.critrevonc.2005.11.004

Cited by 82 publications

(42 citation statements)

References 30 publications

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“…Other tumours types and locations reported to be treated by IORT have been brain tumours, head and neck cancer, metastatic spinal tumours, primary biliary tract, bladder cancer, and liver metastases [102].…”

Section: Miscellaneous Indicationsmentioning

confidence: 99%

Intraoperative radiation therapy

Meiriño

Orecchia

2006

Critical Reviews in Oncology/Hematology

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Section: Miscellaneous Indicationsmentioning

confidence: 99%

Intraoperative radiation therapy

Meiriño

Orecchia

2006

Critical Reviews in Oncology/Hematology

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“…Dose calculations are performed manually, based on dosimetric tables and dose profiles acquired in reference conditions. 2 Although this methodology is a fast and convenient way to carry out IOERT procedures, it does not allow for visualization of patient-specific dose distributions, particularly their heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

In vivodosimetry using Gafchromic films during pelvic intraoperative electron radiation therapy (IOERT)

Costa¹,

Sarmento²,

Gomes³

et al. 2016

BJR

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Objective: To characterize in vivo dose distributions during pelvic intraoperative electron radiation therapy (IOERT) for rectal cancer and to assess the alterations introduced by irregular irradiation surfaces in the presence of bevelled applicators. Methods: In vivo measurements were performed with Gafchromic films during 32 IOERT procedures. 1 film per procedure was used for the first 20 procedures. The methodology was then optimized for the remaining 12 procedures by using a set of 3 films. Both the average dose and two-dimensional dose distributions for each film were determined. Phantom measurements were performed for comparison. Results: For flat and concave surfaces, the doses measured in vivo agree with expected values. For concave surfaces with step-like irregularities, measured doses tend to be higher than expected doses. Results obtained with three films per procedure show a large variability along the irradiated surface, with important differences from expected profiles. These results are consistent with the presence of surface hotspots, such as those observed in phantoms in the presence of step-like irregularities, as well as fluid build-up. Conclusion: Clinical dose distributions in the IOERT of rectal cancer are often different from the references used for prescription. Further studies are necessary to assess the impact of these differences on treatment outcomes. In vivo measurements are important, but need to be accompanied by accurate imaging of positioning and irradiated surfaces. Advances in knowledge: These results confirm that surface irregularities occur frequently in rectal cancer IOERT and have a measurable effect on the dose distribution.

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“…Radical (R0) resection of LR is associated with at least twice higher survival than in non-radical (R1/R2) resection and remains the treatment of choice [21,22]. The tumor-free resection margin is a favorable prognostic factor for improved local control and overall survival [19][20][21][23][24][25][26]. In our study the survival time of patients after R0 resection was longer in comparison to non-radical resection group.…”

Section: Discussionmentioning

confidence: 87%

“…A significant increase in long term survival of patients with recurrent CRC after IORT has been reported [17,19,20]. Radical (R0) resection of LR is associated with at least twice higher survival than in non-radical (R1/R2) resection and remains the treatment of choice [21,22].…”

Section: Discussionmentioning

confidence: 99%