Intrathecal Magnesium Sulfate Protects the Spinal Cord from Ischemic Injury During Thoracic Aortic Cross Clamping

The effect of adding intrathecal magnesium sulphate to bupivacaine–fentanyl spinal anaesthesia

“…In rats, boluses of magnesium produced transient motor and sensory block with no adverse clinical or histological consequences. In a randomized, controlled canine study, no neurological deficit or change in cord histopathology was reported following IT magnesium administration (45–60 mg) (8). A recent human study found no deleterious effects of IT magnesium on spinal opioid analgesia in labouring parturients (4).…”

“…Although systemic MgSO 4 decreases post‐operative opioid requirements in surgical patients, its IT use has not been extensively evaluated clinically (7). However, it has been used safely intrathecally in humans, and its safety profile has been documented by histopathological analysis in experimental studies (8). Magnesium prolongs the duration of spinal opioid analgesia given during labour (4).…”

Diretrizes para o tratamento cirúrgico das doenças da aorta da Sociedade Brasileira de Cirurgia Cardiovascular

“…Drainage of cerebrospinal liquid (CSF) to reduce the intrathecal pressure constitutes another form of medullar protection, widely tested in several animal models, associated or not with infusion of neurotropic-negative drugs [161][162][163][164][165][166] (C) [167] (D).…”

“…Other pharmacological agents proposed as adjuvants in the prevention of paraplegia include corticosteroids [150] (C), mannitol [172] (C), magnesium sulphate [166] (C), prostaglandins [173] (C), allopurinol [174] (C), and flunarizine [175] (D) among others, but none has proved to be effective in the clinical practice.…”

Efeitos neuroprotetores do diltiazem em coelhos com oclusão da aorta

“…Direct intrathecal administrations of some neuroprotective pharmacologic agents have been recommended, because their systemic administration results with intolerable side effects and organtoxicity. Ýntrathecal magnesium sulfate [20], and tetracaine [21] has been tried in combination with hypothermia for prevention of spinal cord ischemia.…”