Intravenous albumin for the prevention of severe ovarian hyperstimulation syndrome in an in vitro fertilization program: a prospective, randomized, placebo-controlled study

Administration of Intravenous Albumin around the Time of Oocyte Retrieval Reduces Pregnancy Rate without Preventing Ovarian Hyperstimulation Syndrome: A Systematic Review and Meta-Analysis

“…All studies used serum level of E 2 and/or number of follicles or oocytes as the basic risk factor of OHSS; however, their cutoff values varied across the 9 studies. Diagnosis of severe OHSS was done according to the criteria of Schenker (1978) in 4 of the 9 trials [9,12,15,16] , whereas others [10,18,19] used the criteria of Navot (1988) or Golan (1989).…”

“…The suggestion that IV albumin might prevent the development of severe OHSS was first introduced in 1993 [8] . Subsequently, 2 studies [9,10] also demonstrated that prophylactic IV administration of 25% albumin (20-50 g) at the time of oocyte retrieval significantly reduced the risk of OHSS when the E 2 levels are markedly elevated or there is a history of a previous episode of OHSS. However, a number of clinical trials showing the ineffectiveness of IV albumin have been conducted subsequently [11][12][13][14][15] ; in contrast, 1 study reported the beneficial effect of IV albumin for preventing OHSS [16] .…”

“…Although studies of its efficacy have had mixed results, a meta-analysis including 5 randomized controlled trials (RCTs) [9,10,12,15,16] denoted that prophylactic albumin administration significantly reduced the risk of developing OHSS [odds ratio (OR) = 0.28, 95% confidence interval (CI) = 0.11-0.73] [17] . Since then, further RCTs have evaluated the effectiveness of albumin infusion on the day of oocyte retrieval and consistently reported that this intervention is not a useful means of preventing the development of OHSS [18,19] .…”

Treatment of polycystic ovary patients undergoing IVF

“…This strategy has been shown to be most useful in the prevention of OHS in patients with high responses (1,12).…”

Comparison of cabergoline and intravenous albumin in the prevention of ovarian hyperstimulation syndrome: a randomized clinical trial

“…human albumin (HA) use for the prevention of OHSS by Asch et al until now, there have been conflicting findings. Some studies suggested a role for albumin in the prevention of OHSS [2][3][4]. However, in several recent studies the effect of HA was similar to a placebo [5,6] and less than other preventive drugs [7][8][9].…”