Intravenous lignocaine and sympathoadrenal responses to laryngoscopy and intubation

Wilson, Iain; Meiklejohn, B. H.; Smith, G.

doi:10.1111/j.1365-2044.1991.tb09403.x

Cited by 49 publications

(22 citation statements)

References 12 publications

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“…Lidocaine has been shown to decrease the sympathetically mediated haemodynamic response to laryngoscopy and intubation [7], which is consistent with our ®ndings (Fig. 2).…”

Section: Discussionsupporting

confidence: 90%

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The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation

Swanton¹,

Iohom²,

Wang³

et al. 2001

European Journal of Anaesthesiology

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Background and objective Respiratory burst is an essential component of the neutrophil's biocidal function. In vitro, sodium thiopental, iso¯urane and lidocaine each inhibit neutrophil respiratory burst. The objectives of this study were (a) to determine the effect of a standard clinical induction/tracheal intubation sequence on neutrophil respiratory burst and (b) to determine the effect of intravenous lidocaine administration during induction of anaesthesia on neutrophil respiratory burst. Methods Twenty ASA I and II patients, aged 18±60 years, undergoing elective surgery were studied. After induction of anaesthesia [fentanyl (2 lg kg )1 ), thiopental (4±6 mg kg )1 ), iso¯urane (end-tidal concentration 0.5±1.5%) in nitrous oxide (66%) and oxygen], patients randomly received either lidocaine 1.5 mg kg )1 (group L) or 0.9% saline (group S) prior to tracheal intubation. Neutrophil respiratory burst was

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“…Lidocaine has been shown to decrease the sympathetically mediated haemodynamic response to laryngoscopy and intubation [7], which is consistent with our ®ndings (Fig. 2).…”

Section: Discussionsupporting

confidence: 90%

“…Intravenous lidocaine has been used in clinical practice for the purpose of decreasing the haemodynamic and sympathetic response to laryngoscopy and tracheal intubation [7]. Therefore, the potential exists for lidocaine to decrease any inhibitory effect of laryngoscopy and intubation on NRB.…”

Section: Introductionmentioning

confidence: 99%

The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation

Swanton¹,

Iohom²,

Wang³

et al. 2001

European Journal of Anaesthesiology

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“…in their study stated that IV lignocaine is beneficial in preventing the hemodynamic changes to laryngoscopy and intubation. [ 18 ] Their results are reiterated by our study too in which we have described similar results. We noted the maximal decline of HR to be at 3 min after intubation [ Graph 1 ], while the maximal decline in SBP and DBP is observed at 5 min postintubation [Graphs 5 and 9 ].…”

Section: Discussionsupporting

confidence: 83%

Comparative analysis of efficacy of lignocaine 1.5 mg/kg and two different doses of dexmedetomidine (0.5 μg/kg and 1 μg/kg) in attenuating the hemodynamic pressure response to laryngoscopy and intubation

et al. 2015

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Context:Laryngoscopy and intubation cause an intense reflex increase in heart rate, blood pressure, due to an increased sympathoadrenal pressor response. Lignoocaine has shown blunting of pressor response to intubation. Dexmedetomidine has sympatholytic effects.Aims:To the best of our knowledge there is no study comparing the efficacy of lignocaine with two different doses of dexmedetomidine for attenuating the pressor response. With this idea, we planned to conduct the present study.Materials and Methods:After approval by the Hospital Ethics committee, 90 consenting adults aged 18-65 years of age of either sex of non-hypertensive ASA Grade I or II were randomly allocated into three groups. Group D1- IV Dexmedetomidine 0.5μg/kg over 10 minutes Group D2- IV Dexmedetomidine 1μg/kg over 10 minutes Group X- IV Lignocaine 1.5mg/kg in 10 ml normal salineStatistical Analysis Used:ANOVA and Student's t test used for analysis.Results:Dexmedetomidine 1µg/kg was more effective than 0.5µg/kg and lignocaine 1.5mg/kg in attenuating the pressor response.Conclusions:We conclude that dexmedetomidine 1μg/kg adequately attenuates the hemodynamic response to laryngoscopy and endotracheal intubation when compared with dexmedetomidine 0.5μg/kg and lignocaine 1.5mg/kg.

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“…Bars represent SEM laryngoscopy and intubation. The method or drug of choice depends on many factors, including the urgency and length of surgery, choice of anesthetic technique, route of administration, medical condition of the patient, and individual preference, but the results are inconclusive [1][2][3][7][8][9][10]19,20]. Since the early 1960s, lidocaine has been focused on blunting the cardiovascular response to intubation, diminishing cough reflexes, dysrhythmia, and rises of intracranial and intraocular pressure [10].…”

Section: Discussionmentioning

confidence: 99%

Nicardipine versus lidocaine for attenuating the cardiovascular response to endotracheal intubation

Charuluxananan

Kyokong

Somboonviboon

et al. 2000

Journal of Anesthesia

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Intravenous lignocaine and sympathoadrenal responses to laryngoscopy and intubation

Cited by 49 publications

References 12 publications

The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation

The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation

Comparative analysis of efficacy of lignocaine 1.5 mg/kg and two different doses of dexmedetomidine (0.5 μg/kg and 1 μg/kg) in attenuating the hemodynamic pressure response to laryngoscopy and intubation

Nicardipine versus lidocaine for attenuating the cardiovascular response to endotracheal intubation

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