Intravenous Magnesium Sulfate Treatment for Acute Asthma in the Emergency Department: A Systematic Review of the Literature

Rowe, Brian H.; Bretzlaff, Jennifer A.; Bourdon, Chris; Bota, Gary W.; Camargo, Carlos A.

doi:10.1067/mem.2000.105659

Cited by 150 publications

(85 citation statements)

References 47 publications

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“…Astım ile ilgili bir meta analizde, intravenöz Mg verilmesinin bu hastalarda hastane kalış süresini azalttığı ve pik inspiratuar akımı arttırdığı gösterilmiştir (25). Kokotajlo ve ark.…”

Section: Astımunclassified

The Unknown Miracle of the Forgotten Element: “Magnesium and Immunity”

Demirtürk¹,

Esen²

2017

tybdd

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47ÖZ Bu derleme magnezyumun pek çok kullanım alanına ek olarak kritik hastada enflamasyon sürecine etkisi, immün sisteme olan katkısını göstermeyi amaçlamıştır. Magnezyum insan vücudunda ekstrasellüler alanda dördüncü sırada, intrasellüler olarak da ikinci olarak en sık bulunan katyonu olup; nükleik asit ve protein sentezi gibi birçok temel reaksiyonda enzim kofaktörü olarak rol alması, hücre membran stabilizasyonunu sağlaması gibi görevleri göz önüne alındığında son derece önemli bir elementtir. Diğer pek çok elektrolite kıyasla en önemli özelliği immün sisteme ve canlı immünitesine olan etkisidir. Yoğun bakımda yatan immünosüpresif ya da immünokompetan olan her grup hastada magnezyum eksikliği desteklenmeli ve pek çok yararına ek olarak magnezyumun immmün sisteme katkısı akılda tutulmalıdır. Anahtar Kelimeler: Magnezyum, immünite, inflamasyon ABSTRACT This review aims to demonstrate the relation between magnesium and the immune system and their effect on inflammatory process in the critical patient, in addition to many other clinical uses of magnesium. Magnesium is the fourth most commonly found cation in the extracellular space in the human body and the second most common cation in the cell. Magnesium is an extremely important element when considering its role as an enzyme cofactor in many basic reactions, such as nucleic acid, protein synthesis and cell membrane stabilization. The most important features compared to other electrolytes is its effect on the immune system and living immunity. For each group of immunosuppressive or immunocompenent patients in intensive care unit, magnesium deficiency should be supported and in addition to other clinical benefits, the contribution of magnesium to the immune system should be kept in mind.

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Section: Astımunclassified

The Unknown Miracle of the Forgotten Element: “Magnesium and Immunity”

Demirtürk¹,

Esen²

2017

tybdd

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“…To illustrate, a recent SR of intravenous magnesium sulfate in acute asthma chose admission to hospital as the primary outcome, relegating other often used but less important measures (e.g., pulmonary function testing) to secondary status. 8 High quality SRs also report adverse events and economic outcomes. For example, an SR of the use of low molecular weight heparin (LMWH) in venous thromboembolism pooled data on thrombocytopenia and major bleeding as important secondary outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…In a recent SR looking at the impact of magnesium sulfate on asthma admission rates, subgroup analysis revealed that patients with severe asthma benefited much more than patients with mild or moderate asthma. 8 Researchers have developed criteria to determine whether subgroup analysis is appropriate. Biological plausibility, a priori subgroup identification, statistically and clinically important effect sizes, a limited number of subgroups analyzed, indirect supporting evidence, within-versus between-study differences, and consistency across studies are all factors to be considered when deciding whether subgrouping is valid.…”

Section: Sensitivity and Subgroup Analysesmentioning

confidence: 99%

Systematic reviews in emergency medicine: Part II. Critical appraisal of review quality, data synthesis and result interpretation

Zed

Rowe²,

Loewen³

et al. 2003

CJEM

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Reviews of the medical literature have always been an important resource for physicians. Increasingly, qualitative and quantitative systematic reviews (SRs) have replaced the traditional "narrative review" as a means of capturing and summarizing current evidence on a topic or, when possible, answering a specific clinical question. This paper is Part II of a 2-part series designed to provide emergency physicians with the background necessary to locate, critically evaluate and interpret SRs. The paper expands on the critical appraisal principles discussed in Part I by focusing on quality assessment, data synthesis and interpretation of results. To illustrate key points and facilitate readability, examples from the emergency medicine literature have been included and technical details have been kept to a minimum. The references, however, are comprehensive and provide a resource for readers seeking further information. RÉSUMÉLes revues de la littérature médicale ont toujours été une ressource importante pour les médecins. De plus en plus, les «revues systématiques» qualitatives et quantitatives ont remplacé les «revues narratives» comme moyen de saisir et résumer les données courantes sur un sujet précis ou, autant que possible, de répondre à une question clinique spécifique. Le présent article constitue la deuxième partie d'une série en deux parties conçue pour donner aux médecins d'urgence le contexte nécessaire pour trouver, faire une évaluation critique et interpréter les revues systéma-tiques. Cet article approfondit davantage les principes de revue critique discutés dans la partie I en élaborant sur l'évaluation de la qualité, la synthèse des données et l'interprétation des résul-tats. Pour illustrer des points-clés et rendre la lecture plus facile, des exemples provenant de la littérature de médecine d'urgence sont inclus et les détails techniques sont maintenus à un strict minimum. Par contre, les références sont exhaustives et offrent des ressources pour les lecteurs à la recherche de plus d'information.

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“…Entretanto, apenas dois estudos 13,14 em pediatria avaliam a efetividade relativa do sulfato de magnésio IV no pronto socorro. Duas revisões sistemáticas 15,16 concluem que as evidências atuais não sustentam a utilização rotineira do sulfato de magnésio IV para os pacientes com asma aguda no setor de emergência, apesar de a droga ser segura e benéfica nos pacientes com asma aguda grave. Uma metanálise 17 recente conclui que, embora a significância clínica de sua utilização (melhora de 16% na espirometria) seja incerta, o sulfato de magnésio IV é seguro e barato, devendo ser considerado em pacientes com broncoespasmo agudo moderado a grave.…”

Section: Veja Artigo Relacionado Na Página 279unclassified

Por que a criança com obstrução grave da via aérea atendida no pronto socorro é diferente

Carvalho¹

2001

J. Pediatr. (Rio J.)

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Intravenous Magnesium Sulfate Treatment for Acute Asthma in the Emergency Department: A Systematic Review of the Literature

Cited by 150 publications

References 47 publications

The Unknown Miracle of the Forgotten Element: “Magnesium and Immunity”

The Unknown Miracle of the Forgotten Element: “Magnesium and Immunity”

Systematic reviews in emergency medicine: Part II. Critical appraisal of review quality, data synthesis and result interpretation

Por que a criança com obstrução grave da via aérea atendida no pronto socorro é diferente

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