Intravenous pharmacokinetics of ciprofloxacin in goats

Pharmacokinetics of ciprofloxacin after single intravenous and repeat oral administration to cats

“…Serum ciprofloxacin disposition curves after intravenous administration were best fit to an open bicompartmental model in all the animals, which is in accordance with most of the results reported for human beings ( Bergan et al, 1987;Dudley et al, 1987) and domestic animals, such as, dogs (Abadía et al, 1994;Cester et al, 1996), rabbits (Barriere et al, 1987), chickens (Atta & Sharif, 1997;Anadón et al, 2001), ponies (Dowling et al, 1995), sheep (Muñ oz et al, 1996 and goats (García Ovando et al, 2000).…”

“…The distribution process was rapid, reflected by a short t 1/2(d) , and comparable with that reported for men (Drusano et al, 1986a), pigs (Fang et al, 2000), chickens (Anadón et al, 2001), ponies (Dowling et al, 1995) and goats (García Ovando et al, 2000). Although in dogs a lower value has been reported (Abadía et al, 1994).…”

“…administration is slightly larger than that reported in dogs, ponies, goats and sheep (Abadía et al, 1994;Dowling et al, 1995;Muñ oz et al, 1996;García Ovando et al, 2000). Elimination half-life was similar to that in humans and other domestic mammals (between 2.5 and 5 h) (Drusano et al, 1986a,b;Bergan et al, 1987;Dudley et al, 1987;Plaisance et al, 1987;Abadía et al, 1994;Yun et al, 1994;Dowling et al, 1995;Cester et al, 1996;Fang et al, 2000;García Ovando et al, 2000). Smaller values were found in birds (Atta & Sharif, 1997;Anadón et al, 2001).…”

“…Ciprofloxacin is a second-generation fluoroquinolone widely used and extensively studied in human medicine (González et al, 1984;Drusano et al, 1986a,b;Tartaglione et al, 1986;Bergan et al, 1987;Dudley et al, 1987;Plaisance et al, 1987). In addition, it has been studied in many animal species, such as rats and monkeys (Siefert et al, 1986), rabbits (Barriere et al, 1987), pigs and calves (Nouws et al, 1988;Fang et al, 2000), ponies (Dowling et al, 1995), horses (Yun et al, 1994), chickens (Atta & Sharif, 1997;García Ovando et al, 1999;Anadón et al, 2001), sheep (Muñ oz et al, 1996), goats (García Ovando et al, 2000) and dogs (Walker et al, 1990;Abadía et al, 1994Abadía et al, , 1995. However, to our knowledge, pharmacokinetic studies in domestic cats have not been reported.…”

A holstein cow–calf model for the transfer of ciprofloxacin through milk after a long‐term intravenous infusion

“…In this study, the parameter values for the pharmacokinetic model are similar to those estimated previously for lactating cows (CL = 12.8 vs. 15.1 mL/min/kg and V ss = 2.3 vs. 2.7 L/kg, respectively) (Jayakumar et al ., ). The pharmacokinetics of ciprofloxacin in cows appears to be similar to that described in ponies (CL = 18.1 mL/min/kg and V ss = 3.5 L/kg), horses (CL = 11.8 mL/min/kg and V ss = 4.9 L/kg), lactating goats (CL = 14.7 mL/min/kg and V ss = 2.1 L/kg), goats (CL = 16.3 and 19.6 mL/min/kg), sheep (CL = 18.0 mL/min/kg), and buffalo calves (CL = 11.8 mL/min/kg and V ss = 2.4 L/kg) (Dowling et al ., ; Munoz et al ., ; El‐Banna & Abo El‐Sooud, ; Garcia Ovando et al ., ; Saini & Srivastava, ; Raina et al ., ). Another study in sheep reported a larger volume of distribution and more rapid clearance (CL = 66.9 mL/min/kg and V ss = 9.4 L/kg) (Rahal et al ., ).…”