Intravenous Salbutamol and Cardiogenic Shock

S, Lal; Savidge, R.S.; Davies, D.M.; Ali, Moumeni; Soni, Vivek Kumar

doi:10.1016/s0140-6736(72)90846-x

Cited by 25 publications

(5 citation statements)

References 3 publications

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“…These findings are consistent with those of Nayler (1971) in respect of a direct coronary vasodilator effect of salbutamol and of Nayler & McInnes (1972) in regard to the maintenance of myocardial efficiency with salbutamol. The findings also lend encouragement to the further evaluation of salbutamol as a therapeutic aid in states of low cardiac output (Gibson & Colthart, 1971;Lal et al, 1972;Wyse, Gibson & Branthwaite, 1974;Sharma et al, 1976).…”

Section: Discussionmentioning

confidence: 79%

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EFFECTS OF β₂‐ADRENOCEPTOR STIMULATION ON CARDIAC METABOLISM IN THE CONSCIOUS DOG

Shanahan

Wahlqvist

Wilmshurst

1979

British J Pharmacology

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The effects of the β2‐adrenoceptor stimulant, salbutamol, on cardiac metabolism have been studied in conscious mongrel dogs. The potential effects of anaesthesia on the study of cardiac metabolism have been avoided by prior implantation of arterial (A) and coronary sinus (CS) catheters for blood sampling and a central venous catheter for infusion. Extraction of substrates for myocardial energy metabolism (CA—CS) was assessed 3 to 24 days post‐operatively. A 100 μg bolus of salbutamol was given followed by an infusion of 3 μg/min for 1 h. Although heart rate increased significantly from 106 to 165 beats/min, fractional extraction of oxygen tended to fall from 84% to 77%. Thus an increase in coronary blood flow rather than in oxygen extraction must have maintained an oxygen supply commensurate with the salbutamol‐induced tachycardia. Neither CA—CS glucose nor fractional glucose extraction altered significantly during salbutamol infusion despite increases in arterial concentration (CA) of glucose and arterial insulin immunoreactivity and a decrease in CA of free fatty acids (FFA). This suggests that an insulin‐antagonistic action accompanies the infusion of salbutamol. The fractional extraction of lactate increased during salbutamol infusion. In part, this may have been a reflection of a decreased myocardial extraction of FFA with salbutamol in this model.

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Section: Discussionmentioning

confidence: 79%

“…1971;Turnheim & Kraupp, 1971). There is some evidence that salbutamol is of therapeutic value in low output states due to cardiogenic shock (Gibson & Coltart, 1971;Lal, Savidge, Davies, Ali & Soni, 1972;Wyse, Gibson & Branthwaite, 1974;Sharma, Goodwin & Steiner. 1976).…”

Section: Introductionmentioning

confidence: 99%

EFFECTS OF β₂‐ADRENOCEPTOR STIMULATION ON CARDIAC METABOLISM IN THE CONSCIOUS DOG

Shanahan

Wahlqvist

Wilmshurst

1979

British J Pharmacology

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“…Salbutamol, a f2-adrenergic receptor agonist has been shown to improve left ventricular function in patients with acute low cardiac output syndromes (Lal, Savidge, Davies Ali & Soni, 1972;Yacoub & Boyland, 1973;Wyse, Gibson & Branthwaite, 1974) and chronic congestive cardiac failure (Sharma, Goodwin & Steiner, 1977). This agent has a relatively prolonged duration of action after intravenous administration which is a disadvantage in the management of acutely ill patients with cardiac failure.…”

Section: Introduction Methodsmentioning

confidence: 99%

Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline.

Stephens¹,

Hayward²,

Ead³

et al. 1978

Brit J Clinical Pharma

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I Rimiterol and isoprenaline produced significant dose-related increases in cardiac output. 2 These changes in cardiac output were accompanied by increases in heart rate and myocardial oxygen consumption which were similar for each drug and dose-related. 3 Isoprenaline in contrast with rimiterol produced direct coronary vasodilation, i.e. coronary vasodilation in excess of that required to meet increases in myocardial oxygen demands.4 It is suggested that the P-adrenergic receptors in the human coronary vasculature are mainly of the /5, type.

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“…A previous investigation (Gibson and Coltart, 1971) indicated that these effects would be less marked when a comparable increase in cardiac output was brought about by salbutamol infusion, and the authors suggested that the drug might be of value in the treatment of low output states due to cardiogenic shock. Acting on this Lal et al (1972) claimed clinical evidence of improvement in nine out of 12 patients suffering from cardiogenic shock after myocardial infarction who were treated with intravenous injections of salbutamol (1-2 mg). The present study was designed to investigate the effect of substituting salbutamol for isoprenaline in a group of patients whose clinical condition needed circulatory support after open-heart surgery.…”

Section: Introductionmentioning

confidence: 99%

Haemodynamic Effects of Salbutamol in Patients Needing Circulatory Support after Open-heart Surgery

Wyse¹,

Gibson²,

Branthwaite³

1974

BMJ

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Intravenous Salbutamol and Cardiogenic Shock

Cited by 25 publications

References 3 publications

EFFECTS OF β₂‐ADRENOCEPTOR STIMULATION ON CARDIAC METABOLISM IN THE CONSCIOUS DOG

EFFECTS OF β₂‐ADRENOCEPTOR STIMULATION ON CARDIAC METABOLISM IN THE CONSCIOUS DOG

Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline.

Haemodynamic Effects of Salbutamol in Patients Needing Circulatory Support after Open-heart Surgery

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Intravenous Salbutamol and Cardiogenic Shock

Cited by 25 publications

References 3 publications

EFFECTS OF β2‐ADRENOCEPTOR STIMULATION ON CARDIAC METABOLISM IN THE CONSCIOUS DOG

EFFECTS OF β2‐ADRENOCEPTOR STIMULATION ON CARDIAC METABOLISM IN THE CONSCIOUS DOG

Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline.

Haemodynamic Effects of Salbutamol in Patients Needing Circulatory Support after Open-heart Surgery

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Product

Resources

About

EFFECTS OF β₂‐ADRENOCEPTOR STIMULATION ON CARDIAC METABOLISM IN THE CONSCIOUS DOG

EFFECTS OF β₂‐ADRENOCEPTOR STIMULATION ON CARDIAC METABOLISM IN THE CONSCIOUS DOG