Intrinsically radiopaque hydrogels for nucleus pulposus replacement

Boelen, Ellen; Hooy-Corstjens, Catharina S. J. van; Bulstra, Sjoerd K.; Ooij, André van; Rhijn, Lodewijk W. van; Koole, Léo H.

doi:10.1016/j.biomaterials.2005.04.020

Cited by 49 publications

(58 citation statements)

References 33 publications

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“…On the other hand, chemical crosslinked PVA-based systems were obtained by photopholymerization of glycidyl methacrylate modified PVA and they displayed viscoelastic behavior similar to NP (Bader and Rochefort, 2007). Moreover, hydrogels based on copolymers of NVP/HEMA (N-vinyl-2-pyrrolidone and 2-hydroxyethylmathacrylate) crosslinked with allylmethacrylate showed water content, fatigue resistance and recovery after loading suitable for NP substitute (Boelen et al, 2005). In the search for naturally based systems, polysaccharide-based hydrogels have also been studied as a nucleus substitute.…”

Section: Injectable Hydrogelmentioning

confidence: 97%

Spinal disc implants using hydrogels

Borzacchiello

Gloria²,

Santis³

et al. 2011

Biomedical Hydrogels

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Section: Injectable Hydrogelmentioning

confidence: 97%

Spinal disc implants using hydrogels

Borzacchiello

Gloria²,

Santis³

et al. 2011

Biomedical Hydrogels

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“…With regard to synthetic hydrogels, physically crosslinked hydrogel based on polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) [114], and on NVP/HEMA (N-vinyl-2-pyrrolidone and 2-hydroxyethylmathacrylate) based hydrogel [115] have been studied. In any case, none of the above mentioned materials presented the desired biological cues and the required behavior [111,116].…”

Section: Intervertebral Disc: From Repair To Regenerationmentioning

confidence: 99%

Hydrogel-Based Platforms for the Regeneration of Osteochondral Tissue and Intervertebral Disc

et al. 2012

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Hydrogels currently represent a powerful solution to promote the regeneration of soft and hard tissues. Primarily, they assure efficient bio-molecular interactions with cells, also regulating their basic functions, guiding the spatially and temporally complex multi-cellular processes of tissue formation, and ultimately facilitating the restoration of structure and function of damaged or dysfunctional tissues. In order to overcome basic drawbacks of traditional synthesized hydrogels, many recent strategies have been implemented to realize multi-component hydrogels based on natural and/or synthetic materials with tailored chemistries and different degradation kinetics. Here, a critical review of main strategies has been proposed based on the use of hydrogels-based devices for the regeneration of complex tissues, i.e., osteo-chondral tissues and intervertebral disc.

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“…(1) Copolymerization of MMA with zinc and barium acrylates produced dental resins of acceptable radiopacity (15); (2) a copolymer of MMA of 3,2-dibromopropyl methacrylate (15); (3) a copolymer of 3,5-diacetamido-2,4,6-triiodobenzoic acid with ethylene glycol diglycidyl ether (28); (4) polyiodinated acrylic monomers (such as 3-acrylamido-2,4.6-triiodobenzoic acid copolymerized with highly hydrophilic acrylate monomers (29); (5) copolymer of hydroxyethyl methacrylate (HEMA) and iodine containing methacrylic monomer (such as 2-(4-iodobenzoyl)-oxo-ethylmethacrylate (4-IEMA) that was synthesized from HEMA and 4-iodobenzyl chloride) (34,35). The radiopacity is rendered by iodine that is covalently bound to the 4-IEMA, whereas the hydrophilic/hydrophobic ratio determines important characteristics such as swelling behavior and stiffness (34); (6) polycarbonate-organopolysiloxane terpolymers (having carbonate, halocarbonate, and organosiloxane components) (33); (7) bismuth acrylates have been copolymerized with common monomers and used as bactericidal paints and coatings for use in hospitals (36).…”

Section: Polymers With Chemically Bound Radiopacifiermentioning

confidence: 99%

Radiopaque Polymers

Cabasso¹

2011

Encyclopedia of Polymer Science and Technology

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Radiopaque polymers have been primarily developed for the service of radiographic nondestructive evaluation by x‐rays absorption. The x‐ray adsorption depends on the fourth power of the atomic number, and consequently elements with high atomic number are associated with effective x‐ray absorption of a material. Materials that are composed of solely of light elements as most polymers are essentially x‐ray transparent. The synthesis of a radiopaque polymer is accomplished by either dispersing the radiopacifying agent into the polymer resin or permanently anchoring the additive to the polymer matrix. So far, only elements in the sixth period (or higher) of the periodical table, except iodine, have been found commonly useful as radiopaque compounds. Iodine, barium, lead, bismuth, and to a lesser degree other organometallic compounds, which can be incorporated into a variety of polymers, have been presently in use in the medical and other fields. Toxicity and uncontrolled degradation and release of the radiopacifier from the polymer matrix are the important factors in the selection of these materials. The preparation, systems relation and measurements, and a wide variety of radiopaque polymers are discussed.

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Intrinsically radiopaque hydrogels for nucleus pulposus replacement

Cited by 49 publications

References 33 publications

Spinal disc implants using hydrogels

Spinal disc implants using hydrogels

Hydrogel-Based Platforms for the Regeneration of Osteochondral Tissue and Intervertebral Disc

Radiopaque Polymers

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