Introducing a novel approach of network oriented analysis of ERPs, demonstrated on adult attention deficit hyperactivity disorder

Shahaf, Goded; Reches, Amit; Pinchuk, Noga; Fisher, Tali; Bashat, G. Ben; Kanter, A.; Tauber, I.; Kerem, D; Laufer, Ilan; Aharon‐Peretz, Judith; Pratt, Hillel; Geva, Amir B.

doi:10.1016/j.clinph.2011.12.010

Cited by 32 publications

(38 citation statements)

References 54 publications

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“…Because pain is a multidimensional phenomenon, 1,16 it is necessary to represent pain perception in a multivariate manner 38 and not just by relying on a single dimension (eg, CHEPs amplitudes). Therefore, in this study we used an ERP analysis tool, BNA, 33–35,39 to assess the reorganization of brain networks, after HD-tDCS stimulation.…”

Section: Discussionmentioning

confidence: 99%

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Clinically Effective Treatment of Fibromyalgia Pain With High-Definition Transcranial Direct Current Stimulation: Phase II Open-Label Dose Optimization

Castillo-Saavedra

Gebodh

Bikson

et al. 2016

The Journal of Pain

113

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Despite promising preliminary results in treating fibromyalgia (FM) pain, no neuromodulation technique has been adopted in clinical practice because of limited efficacy, low response rate, or poor tolerability. This phase II open-label trial aims to define a methodology for a clinically effective treatment of pain in FM by establishing treatment protocols and screening procedures to maximize efficacy and response rate. High-definition transcranial direct current stimulation (HD-tDCS) provides targeted subthreshold brain stimulation, combining tolerability with specificity. We aimed to establish the number of HD-tDCS sessions required to achieve a 50% FM pain reduction, and to characterize the biometrics of the response, including brain network activation pain scores of contact heat-evoked potentials. We report a clinically significant benefit of a 50% pain reduction in half (n = 7) of the patients (N = 14), with responders and nonresponders alike benefiting from a cumulative effect of treatment, reflected in significant pain reduction (P = .035) as well as improved quality of life (P = .001) over time. We also report an aggregate 6-week response rate of 50% of patients and estimate 15 as the median number of HD-tDCS sessions to reach clinically meaningful outcomes. The methodology for a pivotal FM neuromodulation clinical trial with individualized treatment is thus supported.

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Section: Discussionmentioning

confidence: 99%

“…In addition, we assessed biomarkers of response, including an electroencephalography (EEG)/ event-related potential (ERP) analysis of brain reorganization, known as brain network activation (BNA). 33,36,39 The exploratory aims were to test screening procedures to predict response and individualize treatment.…”

mentioning

confidence: 99%

Clinically Effective Treatment of Fibromyalgia Pain With High-Definition Transcranial Direct Current Stimulation: Phase II Open-Label Dose Optimization

Castillo-Saavedra

Gebodh

Bikson

et al. 2016

The Journal of Pain

113

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“…The BNA algorithm extracts spatiotemporal patterns composed of a set of such temporally-dependent event-pairs contained in multiple unitary events. Previously it was shown that volume conduction is unlikely to be responsible for the temporal contingency between events (Shahaf et al, 2012). …”

Section: Methodsmentioning

confidence: 99%

“…Here, we employed a novel EEG network analysis method, Brain Network Activation (BNA) algorithm (Reches et al, 2013; Shahaf et al, 2012), to isolate the characteristic network patterns associated with neural task-based responses modulated by donepezil (for details see “BNA analysis” in Methods). BNA is based on the high temporal resolution of ERPs, and by using a formal graph representation depicts the evolving network dynamics in time, location and frequency.…”

Section: Introductionmentioning

confidence: 99%

Network dynamics predict improvement in working memory performance following donepezil administration in healthy young adults

Reches¹,

Laufer²,

Ziv³

et al. 2014

NeuroImage

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Attentional selection in the context of goal-directed behavior involves top-down modulation to enhance the contrast between relevant and irrelevant stimuli via enhancement and suppression of sensory cortical activity. Acetylcholine (ACh) is believed to be involved mechanistically in such attention processes. The objective of the current study was to examine the effects of donepezil, a cholinesterase inhibitor that increases synaptic levels of ACh, on the relationship between performance and network dynamics during a visual working memory (WM) task involving relevant and irrelevant stimuli. Electroencephalogram (EEG) activity was recorded in 14 healthy young adults while they performed a selective face/scene working memory task. Each participant received either placebo or donepezil (5 mg, orally) on two different visits in a double-blinded study. To investigate the effects of donepezil on brain network dynamics we utilized a novel EEG-based Brain Network Activation (BNA) analysis method that isolates location–time–frequency interrelations among event-related potential (ERP) peaks and extracts condition-specific networks. The activation level of the network modulated by donepezil, reflected in terms of the degree of its dynamical organization, was positively correlated with WM performance. Further analyses revealed that the frontal–posterior theta–alpha sub-network comprised the critical regions whose activation level correlated with beneficial effects on cognitive performance. These results indicate that condition-specific EEG network analysis could potentially serve to predict beneficial effects of therapeutic treatment in working memory.

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“…According to the above results, due to the distributed nature of the prolonged activity, a single electrode may suffice for an effective marker of this neurophysiologic process. This is considerably more convenient than the use of many electrodes for the same goal (as suggested for example on the basis of the same dataset in Shahaf et al, 2012 or from another dataset in Muller et al, 2011). In-fact, because we identified only a limited number of spatially distributed activities, using a few electrodes (or in this case just one) should not result in significant loss of precision.…”

Section: The Processes Identifiedmentioning

confidence: 95%

Comprehensive analysis suggests simple processes underlying EEG/ERP – Demonstration with the go/no-go paradigm in ADHD

Shahaf

Fisher

Aharon‐Peretz

et al. 2015

Journal of Neuroscience Methods

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Introducing a novel approach of network oriented analysis of ERPs, demonstrated on adult attention deficit hyperactivity disorder

Cited by 32 publications

References 54 publications

Clinically Effective Treatment of Fibromyalgia Pain With High-Definition Transcranial Direct Current Stimulation: Phase II Open-Label Dose Optimization

Clinically Effective Treatment of Fibromyalgia Pain With High-Definition Transcranial Direct Current Stimulation: Phase II Open-Label Dose Optimization

Network dynamics predict improvement in working memory performance following donepezil administration in healthy young adults

Comprehensive analysis suggests simple processes underlying EEG/ERP – Demonstration with the go/no-go paradigm in ADHD

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