Introduction of marine-derived<i>Streptomyces</i>sp. UTMC 1334 as a source of pyrrole derivatives with anti-acetylcholinesterase activity

Almasi, Faezeh; Mohammadipanah, Fatemeh; Adhami, Hamid-Reza; Hamedi, Javad

doi:10.1111/jam.14043

Cited by 32 publications

(16 citation statements)

References 69 publications

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“…Previous studies had found that peptides prevented cognitive impairment by improving the composition of the gut microbiota and its metabolites [ 61 ]. As we expected, this study found that THPH administration altered gut microbiota diversity in cognitive impairment mice, including increasing the abundance of Actinobacterota , which produced metabolites with anti-AchE activity [ 62 ]. THPH treatment also increased the abundance of probiotics, such as Lactobacillus reuteri and Prevotellaceae UCG-001 , which had the effects of regulating neural behavior and improving cognitive function, and produced metabolites that participated in the hosts’ lipid metabolism to maintain the brain function [ 63 , 64 , 65 , 66 ].…”

Section: Discussionmentioning

confidence: 75%

Tilapia Head Protein Hydrolysate Attenuates Scopolamine-Induced Cognitive Impairment through the Gut-Brain Axis in Mice

Zhu

et al. 2021

Foods

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The destruction of the homeostasis in the gut-brain axis can lead to cognitive impairment and memory decline. Dietary intervention with bioactive peptides from aquatic products is an innovative strategy to prevent cognitive deficits. The present study aimed to determine the neuroprotective effect of tilapia head protein hydrolysate (THPH) on scopolamine-induced cognitive impairment in mice, and to further explore its mechanism through the microbiota–gut-brain axis. The results showed that THPH administration significantly improved the cognitive behavior of mice, and normalized the cholinergic system and oxidative stress system of the mice brain. The histopathological observation showed that THPH administration significantly reduced the pathological damage of hippocampal neurons, increased the number of mature neurons marked by NeuN and delayed the activation of astrocytes in the hippocampus of mice. In addition, THPH administration maintained the stability of cholinergic system, alleviated oxidative stress and further improved the cognitive impairment by reshaping the gut microbiota structure of scopolamine-induced mice and alleviating the disorder of lipid metabolism and amino acid metabolism in serum. In conclusion, our research shows that THPH supplementation is a nutritional strategy to alleviate cognitive impairment through the gut-brain axis.

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Section: Discussionmentioning

confidence: 75%

Tilapia Head Protein Hydrolysate Attenuates Scopolamine-Induced Cognitive Impairment through the Gut-Brain Axis in Mice

Zhu

et al. 2021

Foods

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“…to improve AD hallmarks, were evaluated. Compounds were able to protect SH-SY5Y neuroblastoma cells from H 2 O 2 -induced oxidative injury by activating the nuclear factor E2-related factor (Nrf2) [ 106 ].…”

Section: Main Textmentioning

confidence: 99%

Promising bioactive compounds from the marine environment and their potential effects on various diseases

Karthikeyan

Joseph

Nair

2022

Journal of Genetic Engineering and Biotechnology

145

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Background The marine environment hosts a wide variety of species that have evolved to live in harsh and challenging conditions. Marine organisms are the focus of interest due to their capacity to produce biotechnologically useful compounds. They are promising biocatalysts for new and sustainable industrial processes because of their resistance to temperature, pH, salt, and contaminants, representing an opportunity for several biotechnological applications. Encouraged by the extensive and richness of the marine environment, marine organisms’ role in developing new therapeutic benefits is heading as an arable field. Main body of the abstract There is currently much interest in biologically active compounds derived from natural resources, especially compounds that can efficiently act on molecular targets, which are involved in various diseases. Studies are focused on bacteria and fungi, isolated from sediments, seawater, fish, algae, and most marine invertebrates such as sponges, mollusks, tunicates, coelenterates, and crustaceans. In addition to marine macro-organisms, such as sponges, algae, or corals, marine bacteria and fungi have been shown to produce novel secondary metabolites (SMs) with specific and intricate chemical structures that may hold the key to the production of novel drugs or leads. The marine environment is known as a rich source of chemical structures with numerous beneficial health effects. Presently, several lines of studies have provided insight into biological activities and neuroprotective effects of marine algae, including antioxidant, anti-neuroinflammatory, cholinesterase inhibitory activity, and neuronal death inhibition. Conclusion The application of marine-derived bioactive compounds has gained importance because of their therapeutic uses in several diseases. Marine natural products (MNPs) display various pharmaceutically significant bioactivities, including antibiotic, antiviral, neurodegenerative, anticancer, or anti-inflammatory properties. The present review focuses on the importance of critical marine bioactive compounds and their role in different diseases and highlights their possible contribution to humanity.

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“…Streptomyces sp. UTMC 1334 also known as Streptomyces lateritius was shown to produce pyrroles and other metabolites with AChE inhibitory activity (Almasi et al 2018 ). Astrocytes protect the nervous system from oxidative damages caused by ROS generation (Drukarch et al 1998 ).…”

Section: Neuro- and Cardioprotective Effects Of Bacterial Extractsmentioning

confidence: 99%

Therapeutic applications and biological activities of bacterial bioactive extracts

et al. 2021

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Bacteria are rich in a wide variety of secondary metabolites, such as pigments, alkaloids, antibiotics, and others. These bioactive microbial products serve a great application in human and animal health. Their molecular diversity allows these natural products to possess several therapeutic attributes and biological functions. That’s why the current natural drug industry focuses on uncovering all the possible ailments and diseases that could be combated by bacterial extracts and their secondary metabolites. In this paper, we review the major utilizations of bacterial natural products for the treatment of cancer, inflammatory diseases, allergies, autoimmune diseases, infections and other diseases that threaten public health. We also elaborate on the identified biological activities of bacterial secondary metabolites including antibacterial, antifungal, antiviral and antioxidant activities all of which are essential nowadays with the emergence of drug-resistant microbial pathogens. Throughout this review, we discuss the possible mechanisms of actions in which bacterial-derived biologically active molecular entities could possess healing properties to inspire the development of new therapeutic agents in academia and industry.

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Introduction of marine-derivedStreptomycessp. UTMC 1334 as a source of pyrrole derivatives with anti-acetylcholinesterase activity

Abstract: This study highlights that exploring new lead anti-AChE compounds may result in discovering novel adjuvant candidates with potency in the treatment of cognitive diseases such as AD.

Cited by 32 publications

References 69 publications

Tilapia Head Protein Hydrolysate Attenuates Scopolamine-Induced Cognitive Impairment through the Gut-Brain Axis in Mice

Tilapia Head Protein Hydrolysate Attenuates Scopolamine-Induced Cognitive Impairment through the Gut-Brain Axis in Mice

Promising bioactive compounds from the marine environment and their potential effects on various diseases

Therapeutic applications and biological activities of bacterial bioactive extracts

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