Introductory Chapter: Drug Delivery Concepts

Maiti, Sabyasachi; Sen, Kalyan Kumar

doi:10.5772/65245

Cited by 20 publications

(23 citation statements)

References 26 publications

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“…Moreover, drug carriers enhance the pharmacokinetic effect, protect the medicinal agent from degradation via enzymes, and carry lipophilic and hydrophilic drugs to meet the intended usage of the system. 7 Targeted drug delivery is an approach to deliver the therapeutic agents to an intended organ or tissue to increase the efficacy and reduce toxicity. 7 Two essential requirements must be fulfilled to have a successful drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

<p>A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems</p>

Albinali¹,

Zagho²,

Deng³

et al. 2019

IJN

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Magnetic core–shell nanocarriers have been attracting growing interest owing to their physicochemical and structural properties. The main principles of magnetic nanoparticles (MNPs) are localized treatment and stability under the effect of external magnetic fields. Furthermore, these MNPs can be coated or functionalized to gain a responsive property to a specific trigger, such as pH, heat, or even enzymes. Current investigations have been focused on the employment of this concept in cancer therapies. The evaluation of magnetic core–shell materials includes their magnetization properties, toxicity, and efficacy in drug uptake and release. This review discusses some categories of magnetic core–shell drug carriers based on Fe 2 O 3 and Fe 3 O 4 as the core, and different shells such as poly(lactic-co-glycolic acid), poly(vinylpyrrolidone), chitosan, silica, calcium silicate, metal, and lipids. In addition, the review addresses their recent potential applications for cancer treatment.

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Section: Introductionmentioning

confidence: 99%

<p>A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems</p>

Albinali¹,

Zagho²,

Deng³

et al. 2019

IJN

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“…[6]. Colloidal carriers aid in solubilization of lipophilic drug, protect the sensitive drug from degradation in biological fluid, reduce toxic side effect, improve patient compliances, prolong the duration of action and drug targeting potentiality [7].…”

Section: Colloidal Drug Carrier and Solid Lipid Nanoparticlesmentioning

confidence: 99%

Solid Lipid Based Nano-particulate Formulations in Drug Targeting

Mohanta¹,

Dinda²,

Palei³

et al. 2020

Role of Novel Drug Delivery Vehicles in Nanobiomedicine

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Recently, targeted drug delivery systems have gained much more interest for delivering varieties of drugs as well as imaging agents specifically to the targeted disease cells or tissues. These are well known for their increased precision and accuracy in mode of drug delivery along with reduced side effects. Though numerous carriers are being employed for drug targeting, the solid lipid based nanoparticles (SLNs) are preferred over them owing to their ability to encapsulate wide varieties of drugs, biocompatibility, ease of surface modification, scaling up feasibility, and possibilities of both active as well as passive targeting to various organs. Surface of these drug loaded SLNs can be modified by conjugating different ligands to enhance their tissue/organ targeting ability and therapeutic efficacy to much higher extent. In this chapter, we have discussed about the SLNs and their different surface modified forms for passive as well as active targeting to different organ such as (colon, breast, lungs, liver, kidney, brain, eyes, etc.) in combating different diseases.

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“…Nowadays, complex diseases, like cancer, have attracted much attention due to their being one of the most significant causes of death 1,2 . Scientists examined two approaches to deal with such diseases: conventional delivery of drugs as well as novel drug delivery systems (NDDS) 3,4 …”

Section: Introductionmentioning

confidence: 99%

Targeted delivery, drug release strategies, and toxicity study of polymeric drug nanocarriers

Abasian

Shakibi

Maniati

et al. 2020

Polymers for Advanced Techs

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Science has been trying to deal with complex diseases, like cancer, for a long time. Indeed, the side effects of the conventional treatment methods are tremendous, in some cases irreversible. This kind of problems demands a solution. Therefore, novel drug delivery systems are devised to mitigate the negative impacts of conventional ones. Polymeric nanocarrier systems are of great importance in this newly opened field. Polymers having been vastly investigated are common in some properties, such as their being biocompatibility and biodegradability. Generally speaking, a set of properties is required to achieve optimum delivery of drugs to target organs with minimum side effects. To do so, some measures should be taken. First of all, the strategy for release should be determined, categorized into two main branches, active and passive. Next, the drug release method should be engineered. Generally, there are two main categories for drug release, exogenous and endogenous. In this review, some of the chief subcategories of any aforementioned items are discussed. In the end, we catch up on already engineered nanocarriers' administration to the human body, possible toxic effects, if any, and the routes for affecting as a toxin.

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Introductory Chapter: Drug Delivery Concepts

Cited by 20 publications

References 26 publications

<p>A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems</p>

<p>A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems</p>

Solid Lipid Based Nano-particulate Formulations in Drug Targeting

Targeted delivery, drug release strategies, and toxicity study of polymeric drug nanocarriers

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Introductory Chapter: Drug Delivery Concepts

Cited by 20 publications

References 26 publications

<p>A perspective on magnetic core&ndash;shell carriers for responsive and targeted drug delivery systems</p>

<p>A perspective on magnetic core&ndash;shell carriers for responsive and targeted drug delivery systems</p>

Solid Lipid Based Nano-particulate Formulations in Drug Targeting

Targeted delivery, drug release strategies, and toxicity study of polymeric drug nanocarriers

Contact Info

Product

Resources

About

<p>A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems</p>

<p>A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems</p>