Inverse association of plasma level of high-density lipoprotein cholesterol with intracerebral hemorrhage

Wang, Xinguo; Li, Shaohua; Bai, Yulong; Fan, Xiaohan; Sun, Kai; Wang, Jizheng; Hui, Rutai

doi:10.1194/jlr.p008755

Cited by 14 publications

(9 citation statements)

References 45 publications

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“…Excessive alcohol consumption is a risk factor for stroke (Ariesen et al, 2003), and despite the general inverse association between HDL-C and stroke (Wang et al, 2011), Bots et al (2002) reported a positive association between these. Specific types of polymorphisms of HDL-C are known to lead to very high serum HDL-C levels of larger particle size which has been associated with an increased risk for CVD (Van der Steeg et al, 2008).…”

Section: Discussionmentioning

confidence: 98%

A comparison of the cardiometabolic profile of black South Africans with suspected non-alcoholic fatty liver disease (NAFLD) and excessive alcohol use

Zatu

Rooyen

Loots

et al. 2015

Alcohol

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Section: Discussionmentioning

confidence: 98%

A comparison of the cardiometabolic profile of black South Africans with suspected non-alcoholic fatty liver disease (NAFLD) and excessive alcohol use

Zatu

Rooyen

Loots

et al. 2015

Alcohol

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“…17,18,20 That cholesterol is known to have effects on the vasculature and is essential for normal membrane fluidity may be an explanation to the above findings 23 . Though earlier studies had showed an inverse relation between serum total cholesterol or high HDL level and hemorrhagic stroke 9,22 , Sugata Roy et al 25 found no such association. Some previous studies found negative results whereas others found a positive association with high serum triglyceride concentrations and risk of stroke 24 .…”

Section: Results and Observationsmentioning

confidence: 83%

“…The 30 day mortality ranges between 30% to 40% in hospital based studies 6,7 . Modifiable risk factors that increase the incidence of stroke include hypertension, smoking, alcohol, diabetes, dyslipidemia [8][9][10] beside some non-modifiable risk factors 11,12 . Attempts are being made to device optimal management strategies and to identify those who stand a poor prognosis with the available investigation and treatment options.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Factors in Intracerebral Hemorrhage: A Hospital Based Prospective Study

Goswami¹,

Sharma²,

Das³

et al. 2016

IJMRP

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Introduction: Intracerebral hemorrhage (ICH), a form of stroke syndrome results from the rupture of an intracerebral vessel leading to the development of a hematoma in the substance of the brain. Incidence rates are particularly high in Asians and Blacks. Attempts are made to prognosticate ICH patients and manage them accordingly. This is particularly important for the socio-economic profile of the patients availing our services. Methods: All together 90 patients of ICH were taken up in this study done in Gauhati Medical College and Hospital during the period from July 2013 to June 2015. Patients were diagnosed on the basis of a thorough medical history, a full neurological examination, standardized blood tests and CT scan of the brain. Prognostication was done on the basis of clinical and radiological findings. Prognosis was assessed as good or bad outcome on the 15th day based on neurological examination. Statistical analysis was done by using the chi-square test, fisher's t-test and student's t-test wherever applicable. Results: In our study 35.55% patients showed bad outcome. Increasing age, low level of consciousness, low GCS score, bilateral limb weakness, high blood pressure, gaze palsies, pupillary abnormalities and CT brain findings of higher volume (>=30 ml) of hematoma, midline shift, intraventricular extension and a high ICH score were associated with bad outcome.

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“…In our study we found that the triglyceride level is negatively significant and LDL-C has non-significant negative association with hemorrhagic stroke. Wang et al 2011also found that hemorrhagic stroke is inversely associated with plasma serum high density lipoprotein cholesterol (HDL-C) (32). A study of Zeng et al 2019 observed that serum HDL and ratio of LDL and HDL was not associated with hemorrhagic stroke (33).…”

Section: Resultsmentioning

confidence: 99%

Diagnostic Value of Lipid Profile in Hemorrhagic Stroke Patients

Shrivastav¹,

Singh²,

Kushwaha³

et al. 2019

EJMR

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The relation between lipid profile and hemorrhagic stroke is controversial till now. Many epidemiological studies show inverse association of total cholesterol and triglycerides with hemorrhagic stroke. We analyze diagnostic role of lipid profile parameter in hemorrhagic stroke via case control study. The aim was to investigate lipid profile in hemorrhagic stroke patients and healthy control persons. Total 100 subject's case and control were included in this study and divided in two groups. 50 are hemorrhagic stroke patients and 50 are healthy control. Patients age <18, renal and hepatic impairment and familial hypercholesterolemia and hyperthyroidism were excluded. The inclusion of age group was between (64.8±11.9) and (48.9 ±9.9). Statistical analysis was done by using SPSS version 21.0. p value was calculated by ANOVA unpaired t-test. The p<0.05 was considered a statistically significant. The mean value of Total cholesterol (p=0.0001*) and Triglycerides (p=0.0254) were significantly low in hemorrhagic stroke patients compared with healthy control respectively. The mean LDL-C and VLDL-C were also significantly low in hemorrhagic stroke compared to healthy individuals (p=0.016 and p=0.025) respectively. Similarly, the mean HDL-C was also low in hemorrhagic stroke patients compare to healthy individuals. The hemorrhagic stroke patient's serum total cholesterol and triglycerides (r=-0.0854,p=0.0001 and r=-0.200 and p=0.046) were show significantly negative correlation with healthycontrol. The LDL-C and VLDL-C (r=-0.121 p=0.230 and r=-0.200, p=0.460) were show non-significant negative association in hemorrhagic stroke compare to healthy control respectively. HDL-C of hemorrhagic stroke patient's shows positively non-significantly associated with healthy control (r=0.0891, p=0.3785). This present study concluded that lipid profile levels play significant diagnostic role in hemorrhagic stroke patients. The lower concentration of total cholesterol and triglycerides may predispose individual towards the higher risk of hemorrhagic stroke.

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Inverse association of plasma level of high-density lipoprotein cholesterol with intracerebral hemorrhage

Cited by 14 publications

References 45 publications

A comparison of the cardiometabolic profile of black South Africans with suspected non-alcoholic fatty liver disease (NAFLD) and excessive alcohol use

A comparison of the cardiometabolic profile of black South Africans with suspected non-alcoholic fatty liver disease (NAFLD) and excessive alcohol use

Prognostic Factors in Intracerebral Hemorrhage: A Hospital Based Prospective Study

Diagnostic Value of Lipid Profile in Hemorrhagic Stroke Patients

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