2023
DOI: 10.1101/2023.08.08.552504
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Investigating the impact of motion in the scanner on brain age predictions

Abstract: Introduction: Brain Age Gap (BAG) is defined as the difference between the brain's predicted age and the chronological age of an individual. Magnetic resonance imaging (MRI)-based BAG can quantify acceleration of brain aging, and is used to measure brain health as aging and disease interact. Motion in the scanner is a common occurrence that can affect the acquired MRI data and act as a major confound in the derived models. As such, age related changes in head motion may impact the observed age-related differen… Show more

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“…The educational level was assessed via a composite variable considering UKBB data fields 6138 ("Qualifications") and 845 ("Age completed full time education"), and income via field 738 ("Average total household income before tax"). To ensure presence of subtle motion-related errors did not impact the findings, consistent analyses were also repeated using the FreeSurfer-based Euler number as a proxy for motion during scanning 29 . There were no significant differences between these results and the models that did not account for motion (supplementary materials).…”
Section: Additional Validationsmentioning
confidence: 99%
“…The educational level was assessed via a composite variable considering UKBB data fields 6138 ("Qualifications") and 845 ("Age completed full time education"), and income via field 738 ("Average total household income before tax"). To ensure presence of subtle motion-related errors did not impact the findings, consistent analyses were also repeated using the FreeSurfer-based Euler number as a proxy for motion during scanning 29 . There were no significant differences between these results and the models that did not account for motion (supplementary materials).…”
Section: Additional Validationsmentioning
confidence: 99%