Investigating the mechanophysical and biological characteristics of therapeutic dental cement incorporating copper doped bioglass nanoparticles

Choe, YoungEun; Kim, Yujin; Jeon, Se-Jeong; Ahn, Junyong; Park, Jeong-Hui; Dashnyam, Khandmaa; Mandakhbayar, Nandin; Knowles, Jonathan C.; Kim, Hae‐Won; Jun, Soo-Kyung; Lee, Jung Hwan; Lee, Hae‐Hyoung

doi:10.1016/j.dental.2021.12.019

Cited by 19 publications

(12 citation statements)

References 63 publications

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“…Cu is a kind of essential trace element that involved in multiple enzymatic and cellular processes, which also can prevent bacterial infection of teeth [ [68] , [69] , [70] , [71] ]. And nano-Cu may exert bactericidal, angiogenic, or pro-osteogenic activities in different doses, due to its multifunctional biological activities.…”

Section: Nano-antibacterial Materialsmentioning

confidence: 99%

“…Furthermore, zinc phosphate cement (ZPC) with Cu doped bioglass nanoparticles (Cu-BGn) exhibited sufficient mechanophysical properties and enhanced antibacterial effect ( Fig. 6 D) [ 71 ]. In general, nano-Cu are widely used in the field of oral antibacterial and have broad prospects.…”

Section: Nano-antibacterial Materialsmentioning

confidence: 99%

“…Copyright 2022 American Chemical Society. (D) Schematic, optical, and SEM images of the fabricated ZPC and Cu-BGn incorporated ZPC (Cu-ZPC) to observe the Cu-BGn distribution [ 71 ]. Copyright 2022 Elsevier.…”

Section: Nano-antibacterial Materialsmentioning

confidence: 99%

See 2 more Smart Citations

Recent advances on nanomaterials for antibacterial treatment of oral diseases

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Chu²,

Jiang³

et al. 2023

Materials Today Bio

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Section: Nano-antibacterial Materialsmentioning

confidence: 99%

Section: Nano-antibacterial Materialsmentioning

confidence: 99%

See 1 more Smart Citation

Recent advances on nanomaterials for antibacterial treatment of oral diseases

Chen¹,

Chu²,

Jiang³

et al. 2023

Materials Today Bio

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“…Biocompatible carriers ( Fig. 8 ) [ 61 , 62 ] can prevent the body's immune system from treating them as foreign substances to trigger immune reactions after entering the organism. This type of carriers such as hydroxyapatite (HAP) and bioactive glasses (BG) are mainly used in dental materials, organ stents, drug carriers, and other clinical therapeutic applications.…”

Section: Carriersmentioning

confidence: 99%

The mechanism of metal-based antibacterial materials and the progress of food packaging applications: A review

Yang

Gao

et al. 2022

Ceramics International

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“…Notably, as a therapeutic ion, copper has a strong antimicrobial effect over a wide range but low toxicity for humans [28]. Therefore, a favorable effect can be expected by mixing copper-doped BGn (CuBGn) with other dental materials; for example, Choe et al revealed that ZPC mixed with CuBGn showed relatively good in vitro cell viability and antibacterial effects without affecting mechanical properties [29].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Physical and Biological Properties of a Caries-Arresting Liquid Containing Copper Doped Bioglass Nanoparticles

et al. 2022

Self Cite

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Silver diamine fluoride (SDF) is an outstanding dental material for arresting and preventing caries, but some drawbacks, such as high flowability due to low viscosity and cytotoxicity to the pulp, have been reported. To overcome these problems, copper-doped bioactive glass nanoparticles (CuBGns) were combined with SDF. After synthesis, CuBGns were examined by physical analysis and added in SDF at different weight/volume% (SDF@CuBGn). After assessing physical properties (viscosity and flowability) of SDF@CuBGn, physicochemical properties (morphology before and after simulated body fluid (SBF) immersion and ion release) of SDF@CuBGn-applied hydroxyapatite (HA) discs were evaluated. Biological properties were further evaluated by cytotoxicity test to pulp stem cells and antibacterial effect on cariogenic organisms (Streptococcus mutans and Staphylococcus aureus). Combining CuBGns in SDF increased the viscosity up to 3 times while lowering the flowability. More CuBGns and functional elements in SDF (Ag and F) were deposited on the HA substrate, even after SBF immersion test for 14 days, and they showed higher Cu, Ca, and Si release without changing F and Ag release. Cell viability test suggested lower cytotoxicity in SDF@CuBGn-applied HA, while CuBGns in SDF boosted antibacterial effect against S. aureus, ~27% in diameter of agar diffusion test. In conclusion, the addition of CuBGn to SDF enhances viscosity, Ag and F deposition, and antibacterial effects while reducing cell toxicity, highlighting the role of bioactive CuBGns for regulating physical and biological effects of dental materials.

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Investigating the mechanophysical and biological characteristics of therapeutic dental cement incorporating copper doped bioglass nanoparticles

Cited by 19 publications

References 63 publications

Recent advances on nanomaterials for antibacterial treatment of oral diseases

Recent advances on nanomaterials for antibacterial treatment of oral diseases

The mechanism of metal-based antibacterial materials and the progress of food packaging applications: A review

Characterization of Physical and Biological Properties of a Caries-Arresting Liquid Containing Copper Doped Bioglass Nanoparticles

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