Investigating the Use of Layered Double Hydroxide Nanoparticles as Carriers of Metal Oxides for Theranostics of ROS-Related Diseases

Abstract

Overproduction of reactive oxygen species (ROS) is commonly known as a key factor in the progression of many chronic inflammation diseases such as atherosclerosis and rheumatoid arthritis. In this study, a metal oxide nanodot coated-layered double hydroxide (LDH) nanocomposite is constructed for theranostics of ROS-related diseases. This is the first time that both cerium oxide and iron oxide nanoparticles (NPs) were attached on the surface of LDH NPs through electrostatic interaction via the nanoengineering approach. LDHs served as nanocarriers, cerium oxide NPs served as therapeutic agents due to the antioxidant properties, and iron oxide NPs served as magnetic resonance imaging (MRI) contrast agents. In vitro studies have demonstrated that the constructed nanocomposites have good biocompatibility, good antioxidant capacity to reduce ROS level in the cells, as well as satisfying cell imaging effect in MRI. Functionalization of LDH surface with cerium oxide NPs and iron oxide NPs allows the simultaneous therapy and diagnosis of ROS-related diseases, and may also allow biodistribution tracking of the therapeutic cerium oxide NPs.

Recent Advances in the Development of Theranostic Nanoparticles for Cardiovascular Diseases

“…According to our results, this nanoparticle can be considered as a potential theranostic material for ROS-related inflammatory diseases. In addition, we also synthesised CeO2-Fe3O4@LDH nanocomposites [32]. The rationale of these nanocomposites is similar to the above nanoparticles.…”

Inorganic–inorganic nanohybrids for drug delivery, imaging and photo-therapy: recent developments and future scope

“…In addition, their anion exchange capability, pH responsivity, and cell-penetrability along with endosomal escape are also noticeable. 68,86,87 For example, Li et al used a nanodot-coating technique to make (10-15 nm) sized SiO 2 dot-coatings on the LDH (110 nm) to nally achieve 170 nm sized (SiO 2 @MgAl-LDH) nanohybrids. The as-made nanohybrids were well-dispersible with an optimum size range for drug-delivery applications 88 (Fig.…”

Platinum-Induced Peripheral Neuropathy (PIPN): ROS-Related Mechanism, Therapeutic Agents, and Nanosystems

“…It also attenuated the OXA-induced changes in some key markers [e.g., myelination (MBP), oxidative stress (nitrotyrosine), and astrocyte glial cell activation (glial fibrillary acidic protein (GFAP)] and enzymatic activity (SOD and GPx) ( Abdelhamid et al, 2020 ). Some CeO 2 -based therapeutic agents [e.g., CeO 2 -decorated MSNs ( Wu H. et al, 2018 ), CeO 2 -integrated microneedle patches ( Yuan et al, 2021 )] and theragnostic agents (e.g., Fe 3 O 4 /CeO 2 core–shell NPs) ( Wu Y. et al, 2018 ), Fe 3 O 4 /CeO 2 -coated layered double hydroxide (LDH) nanocomposites ( Liu et al, 2019 ), and Fe 3 O 4 /CeO 2 chitosan nanococktails ( Wu et al, 2021 )] have been developed to scavenge ROS for the treatment and/or diagnosis of ROS-related inflammatory diseases. Moreover, Gao et al synthesized basalin-coated silver (Ag) NPs in aqueous medium using silver nitrate, which alleviated neuropathic pain of OXA-treated mice by decreasing the aluminum (Al) levels in the DRG via chelation ( Gao et al, 2017 ).…”