“…Because of its structural similarities to the extracellular matrix, and its gelling properties under conditions compatible with biological activities, it is widely used in biomedical engineering applications, for example, drug delivery, in vitro cell culture, wound healing, and tissue engineering [ 31 , 32 , 33 ]. Electrospun alginate-based nanofibers have been developed for use in biomedical applications such as wound dressing [ 34 , 35 , 36 ], tissue engineering [ 37 , 38 ], and drug delivery systems [ 39 , 40 ]. The SA polymer in a water-based solution cannot be electrospun alone due to its inadequate chain entanglements.…”