Investigation of <i>Pseudomonas aeruginosa</i> Resistance Pattern against Antibiotics in Clinical Samples from Iranian Educational Hospital

Abstract

Pseudomonas aeruginosa (P. aeroginosa) is one of the opportunistic pathogens, which is the main cause of prevalent hospital infections worldwide. The aim of this study was to determine the prevalence of antibiotic resistance pattern against P. aeroginosa from clinical samples in our population. This study was performed during March 2009 to September 2011. During this period 233 clinical isolated samples from hospital patients were examined. In these studies, different strains of P. aeroginosa were isolated from samples, then microbiologically tested. Bacterial susceptibility was performed by the disc-diffusion tests with Kirby Baur disc diffusion tests in Muller-Hinto environment. Our results showed maximum antibiotic resistance (99.5%) of P. aeruginosa against Trimetoprime Solfametoxasole and Ciprofloxacin (55.33%), Amikacin (61%), Imipenem (33%), which were identified as the most effective antibiotics in this study. In conclusion, indeed most Pseudomonas aeruginosa strains infections are treated as soon as possible due to their severe resistance against antibiotics. So, we have to apply an accurate antibiotic treatment discipline, according to the finding, based on antibiogram, in order to prevent its spread and also, monitoring and optimization of antimicrobial use should be considered carefully.

Prevalence and Antibiotic Resistance of Pseudomonas aeruginosa Isolated from Bovine Meat, Fresh Fish and Smoked Fish.

“…In fact, they isolated P. aeruginosa multi-drug resistant from different infection sites. This high multi resistance could be due to the production of hydrolytic enzymes and the acquisition of resistance mechanisms by Pseudomonas aeruginosa strains [6,12,15]. Multidrug-resistance of these Pseudomonas aeruginosa strains could also be due to residues of antibiotics used in an uncontrolled manner in the production of these animal products [1,27].…”

“…Pseudomonas aeruginosa is also the cause of infection in some animals such as sheep, horses, bovines and dogs [6]. In humans, P. aeruginosa is the cause of dermatitis, meningitis, skin infections in severe burns, sepsis, and nosocomial infections of the urinary tract [8,14,15]. This bacterium is also responsible for ophthalmological and digestive infections [15].…”

“…In humans, P. aeruginosa is the cause of dermatitis, meningitis, skin infections in severe burns, sepsis, and nosocomial infections of the urinary tract [8,14,15]. This bacterium is also responsible for ophthalmological and digestive infections [15]. The prevalence of P. aeruginosa infections is 11.5% in Europe and 17% in developing countries.…”

The Use of Monoclonal Antibodies in the Treatment of Alzheimer Disease

“…In Conclusion, based on reports from previous studies infectious disorders and metabolic disorders, including diabetes and metabolic syndrome [56][57][58][59][60]and cancer had high rate of prevalence [61][62][63].For treatment of the large ranges of diseases, nanotechnology had noticeable role whichnanoparticles have some practices, in medicine and manufacturing [62][63].…”

Investigation of Characteristics and Behavior of Loaded Carboplatin on the, Liposomes Nanoparticles, on the Lung and Ovarian Cancer: An In-Vitro Evaluation

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Majid Hasanzadegan Roudsari, et al: Carboplatin Liposomal Nanoparticles Against Ovarian and Lung According to previous data, between various diseases including diabetes, metabolic syndrome and infectious diseases etc [1][2][3][4][5], cancer has considerable significance [6][7]. Nanoparticles have numerous applications in the fields of medicine and industry [8][9].

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