Investigation of antileshmanial activities of Cuminum cyminum based green silver nanoparticles on L. tropica promastigotes and amastigotes in vitro

Bağırova, Melahat; Dinparvar, Sahar; Allahverdiyev, Adil M.; Unal, Kubra; Abamor, Emrah Şefik; Novruzova, Metanet

doi:10.1016/j.actatropica.2020.105498

Cited by 25 publications

(5 citation statements)

References 22 publications

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“…Nanoparticles synthesized using crude as well as various solvent-fractionated extracts of medically important plants are considered as efficient agents for the delivery of specific phytoconstituents into the cells. Keeping in view the effective antimicrobial activities of silver metal, silver/silver oxide NPs synthesized using a variety of medicinally important plant species, including Mentha arvensis L., Ficus benghalensis, Cuminum cyminum, Moringa oleifera, Silybum marianum, and Sechium edule, at a dosage of 10, 300, 0.5, 246, and 51.88 μg/ml tested against L. tropica, L. donovani, L. tropica, L. major, L. tropica, and Leishmania donovani, respectively (Baranwal et al, 2018;El-Khadragy et al, 2018;Hameed et al, 2019;Ismail et al, 2019;Bagirova et al, 2020;Javed et al, 2020). Gold and silver bimetallic NPs synthesized by using medically important plants have also been reported to be used for the prevention of this disease (Alti et al, 2020).…”

Section: Role Of Plant-based Nanoparticles In the Treatment Of Leishmaniasismentioning

confidence: 99%

Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Sharma

Dhiman

Singh

et al. 2021

Front. Mol. Biosci.

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The present review focuses on a dreaded vector-mediated leishmaniasis, with the existing therapeutic approaches including a variety of drugs along with their limitations, the treatment with natural compounds, and different types of metal/metal oxide nanoparticles (NPs). As evidenced, various metallic NPs, comprising silver, silver oxide, gold, zinc oxide, titanium, lead oxide, etc., played a curative role to treat leishmaniasis, are also presented. Keeping in view the advance success of vaccines against the prevalent dreaded diseases in the past and the present scenario, efforts are also being made to develop vaccines based on these NP formulations.

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Section: Role Of Plant-based Nanoparticles In the Treatment Of Leishmaniasismentioning

confidence: 99%

Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Sharma

Dhiman

Singh

et al. 2021

Front. Mol. Biosci.

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“…Essential oil from cumin was found more efficient than commercial insecticides, and it was proposed in innovative green formulations in crop protection against E. fetida and H. axyridis [ 11 ]. Several studies have suggested to develop nanoparticles based on cumin extracts for effective antleichmaniose [ 12 ] and antitumor activities [ 13 ]. Indeed, cuminaldehyde presents antinociceptive, antineuropathic and anti-inflammatory effects [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Biochemical Composition of Cumin Seeds, and Biorefining Study

et al. 2020

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A new biorefinery approach has been developed in the present study, and applied on cumin (Cuminum cyminum) seeds as a potential source of phytochemicals of interest. Cumin is a popular spice used widely for its distinctive aroma. It is a rich reserve of both vegetable and essential oils. The biorefinery approach here focused on the evaluation of the influence of four different geographical origins (i.e., Lebanon, France, Algeria and Syria) on oil yield and quality in cumin seed, and on the valorization of remaining by-products by investigating their nutritional content and biological activity for the first time. Vegetable and essential oils were extracted, and their compositions were determined. Nutritional traits were also assessed. The delipidated and hydrodistillated cakes just as aromatic water were characterized for their fiber, sugar, protein, phenol and flavonoid contents. Antibacterial and antioxidant activities were also determined. Cumin seeds showed high contents in both vegetable and essential oils, proteins and sugars regardless their origin. Moreover, this Apiaceae species exhibited high levels of petroselinic fatty acid (an isomer of oleic acid) and sterols. Cakes and aromatic water also presented high levels of proteins, fibers, sugars and phenols. These residues revealed interesting antioxidant and antibacterial activities. These results emphasized the potential use of cumin in a biorefinery concept, with a multi-purpose industrial process. In addition, large differences were observed between the four geographical origins for phytochemical contents and compositions. These findings highlight the perspectives for developing selection programs for nutritional traits and industrial interests. All obtained results validate the health promoting effect of cumin composition as well as its industrial importance along with the residues.

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“…The findings showed that whereas AgNPs caused a notable decrease in macrophage cell viability values at the same doses, Bio-AgNPs had no appreciable cytotoxicity toward them at lower concentrations (0.25–0.75 g/mL). The antileshminial activity observed is the result of inhibition of promastigote viability and disturbance in the metabolism of amastigotes along with enhanced release of nitric oxide from host macrophages ( Bagirova et al, 2020 ).…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Biofabrication of nanoparticles: sources, synthesis, and biomedical applications

Kulkarni,

Sherkar,

Shirsathe

et al. 2023

Front. Bioeng. Biotechnol.

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Investigation of antileshmanial activities of Cuminum cyminum based green silver nanoparticles on L. tropica promastigotes and amastigotes in vitro

Cited by 25 publications

References 22 publications

Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Biochemical Composition of Cumin Seeds, and Biorefining Study

Biofabrication of nanoparticles: sources, synthesis, and biomedical applications

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