Investigation of antioxidant and anti-inflammatory activities as well as the renal protective potential of green coffee extract in high fat-diet/streptozotocin-induced diabetes in male albino rats

Green Coffea arabica Extract Ameliorates Testicular Injury in High-Fat Diet/Streptozotocin-Induced Diabetes in Rats

“…The inflammatory reaction shown in the present study can be explained by the following: ROS resulted in the oxidation of protein and lipids in some cellular structures, which causes cell injury [47] by triggering ER (endoplasmic reticulum) stress, debilitating normal mitochondrial function, and disrupting the DNA. These complications enhance NF-κBmediated inflammation in conjunction with the increased levels of proinflammatory mediators such as TNF-α and IL-1β [32]. The levels of inflammatory cytokines decreased significantly after treatment with green coffee, suggesting that green coffee can exert an anti-inflammatory effect by decreasing the IL-1β and TNF-α levels which has been also suggested by numerous studies [10,48].…”

“…It was previously shown that HFD causes insulin insensitivity and then low-dose STZ causes islet cell destruction [30]. Enhanced oxidative stress [2], decreased antioxidant capacity, inflammation [31], and apoptosis [32] have been considered to be the most important mechanisms not only in HFD-but also in STZinduced testicular dysfunction [3].…”

Hypoglycemic potential of selenium nanoparticles capped with polyvinyl-pyrrolidone in streptozotocin-induced experimental diabetes in rats

“…The deficiency or absence of insulin causes hyperglycemia; hence, an increase in the level of free radicals is noticed due to the oxidation of the increased glucose (Amin et al, 2020). Oxidative stress is thereby directly correlated with diabetes and the activity of the system specialized for antioxidant defense of the body is weakened due to hyperglycemia (AlAmri et al, 2020). Selenium (Se) is a necessary micronutrient in our diet and it could down-regulate diabetic symptoms (Pillai et al, 2012).…”

Coffee beverage reduces ROS production and does not affect the organism s response against Candida albicans

“…As for coffee, the studies are often in conflict. Numerous studies describe the antioxidant properties of coffee, while others show the opposite effect (AlAmri et al, 2020;Chu et al, 2011;Kwak et al, 2017;Tomac et al, 2020;Wu et al, 2011). One of the most widely studied and proven properties of coffee is its antioxidant activity related to natural phenolic compounds such as chlorogenic acid, caffeine and melanoidins, which contributes to the improvement of the pathophysiological characteristics of type 2 diabetes mellitus (T2D) (Butt & Sultan, 2011;Chu et al, 2011).…”

“…Information related to the effects of coffee on the body's defense mechanism against pathogens is scarce. Experimental evidence indicates that phenolic compounds can regulate cellular processes that lead to the inflammatory response and can increase defense or not cause any type of effect (AlAmri et al, 2020;Chu et al, 2011). This controversy indicates that the response to the activity of these defenses depends on the etiology of oxidative stress, the experimental protocol, the antioxidant defense in question and the type and source of dietary antioxidant.…”