Investigation of common risk factors between polycystic ovary syndrome and Alzheimer’s disease: a narrative review

Sarahian, Nahid; Sarvazad, Hosna; Sajadi, Elham; Rahnejat, Nasrin; Roozbahani, Narges Eskandari

doi:10.1186/s12978-021-01203-x

Cited by 16 publications

(7 citation statements)

References 116 publications

(140 reference statements)

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“…Studies of PCOS and risk of cognitive decline, dementia, and Alzheimer’s disease are lacking, but the postulation has been made that increased risk may be associated with chronic inflammation, obesity, insulin resistance, and androgenic-mediated effects on the central nervous system that affect cognitive function. 138 …”

Section: Discussionmentioning

confidence: 99%

Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort

Vine,

Ghosh,

Wang

et al. 2024

CJC Open

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Section: Discussionmentioning

confidence: 99%

Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort

Vine,

Ghosh,

Wang

et al. 2024

CJC Open

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“…The various ApoE isoforms differ in their ability to bind lipids and amyloid-β, a critical protein in Alzheimer’s disease [ 36 ]. This finding of increased levels of ApoE may be pertinent in protecting against the potential increased risk of Alzheimer’s disease in PCOS, where it has been shown that these subjects may share some common risk factors [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

HDL-Associated Proteins in Subjects with Polycystic Ovary Syndrome: A Proteomic Study

Butler

Moin

Reiner

et al. 2023

Cells

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Introduction. Serum lipoproteins, with the exception of high-density lipoprotein cholesterol (HDL-C), are increased in polycystic ovary syndrome (PCOS) and their levels may reflect the associated obesity and insulin resistance, but the nature of this association is not fully explained. Therefore, proteomic analysis of key proteins in lipoprotein metabolism was performed. Methods. In this cohort study, plasma was collected from 234 women (137 with PCOS and 97 controls without PCOS). Somalogic proteomic analysis was undertaken for the following 19 proteins involved in lipoprotein, and particularly HDL, metabolism: alpha-1-antichymotrypsin; alpha-1-antitrypsin; apolipoproteins A-1, B, D, E, E2, E3, E4, L1, and M; clusterin; complement C3; hemopexin; heparin cofactor II; kininogen-1; serum amyloid A-1; amyloid beta A-4; and paraoxonase-1. Results. The levels of apolipoprotein E were higher in PCOS (p = 0.012). However, the other isoforms of ApoE, ApoE2, E3, and E4, did not differ when compared with controls. ApoM was lower in PCOS (p = 0.000002). Complement C3 was higher in PCOS (p = 0.037), as was heparin cofactor II (HCFII) (p = 0.0004). The levels of the other proteins associated with lipoprotein metabolism did not differ between PCOS and controls. Conclusions. These data contribute to the concern of the deleterious dyslipidemia found in PCOS, with the novel combination reported here of higher levels of ApoE, C3 and HCFII together with lower ApoM. The dysregulation of these proteins could circumvent the protective effect of HDL-C and contribute to a more atherogenic profile that may increase cardiovascular risk.

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“…VD3 has implicated in bone metabolism, but recently it has been identified as a potential contributor to the extraosseous pathophysiological conditions in many tissues and organs, including brain [17,24,25], kidney [26], immune system [27], skin [28], and others. Our previous results showed accelerated wound repair with VD3 but without complete repair [8].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin D3 and Silver Nanoparticles on HaCaT Cell Viability

Cataldi

Ceccarini

Patria

et al. 2022

IJMS

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Vitamin D3, known to regulate bone homeostasis, has recently been shown to have many pleiotropic effects in different tissues and organs due to the presence of its receptor in a wide range of cells. Our previous study demonstrated that vitamin D3 was able to increase the wound healing respect to the control sample, 24 h after cutting, without however leading to a complete repair. The aim of the study was to combine vitamin D3 with silver nanoparticles to possibly enable a faster reparative effect. The results showed that this association was capable of inducing a complete wound healing only after 18 h. Moreover, a treatment of vitamin D3 + silver nanoparticles yielded a small percentage of keratinocytes vimentin-positive, suggesting the possibility that the treatment was responsible for epithelial to mesenchymal transition of the cells, facilitating wound healing repair. Since vitamin D3 acts via sphingolipid metabolism, we studied the expression of gene encoding for the metabolic enzymes and protein level. We found an increase in neutral sphingomyelinase without involvement of neutral ceramidase or sphingosine kinase2. In support, an increase in ceramide level was identified by Ultrafast Liquid Chromatography–Tandem Mass Spectrometry, suggesting a possible involvement of ceramides in wound healing process.

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Investigation of common risk factors between polycystic ovary syndrome and Alzheimer’s disease: a narrative review

Cited by 16 publications

References 116 publications

Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort

Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort

HDL-Associated Proteins in Subjects with Polycystic Ovary Syndrome: A Proteomic Study

The Effect of Vitamin D3 and Silver Nanoparticles on HaCaT Cell Viability

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