2018
DOI: 10.1208/s12249-018-1064-6
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Investigation of Cyclodextrin-Based Nanosponges for Solubility and Bioavailability Enhancement of Rilpivirine

Abstract: Rilpivrine is BCS class II drug used for treatment of HIV infection. The drug has low aqueous solubility (0.0166 mg/ml) and dissolution rate leading to low bioavailability (32%). Aim of this work was to enhance solubility and dissolution of rilpivirine using beta-cyclodextrin-based nanosponges. These nanosponges are biocompatible nanoporous particles having high loading capacity to form supramolecular inclusion and non-inclusion complexes with hydrophilic and lipophilic drugs for solubility enhancement. Beta-c… Show more

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Cited by 65 publications
(44 citation statements)
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“…Biodegradability, biocompatibility, stability in the pH of 1–11 and negligible toxicity of NSs rendered them as safe drug carriers . To date, NSs have been used for delivery of various drugs such as Rilpivirine, Rosuvastatin calcium, Acyclovir, Norfloxacin, Anti‐restenotic Agent DB103, Doxorubicin and Captopril, Efavirenz, Nifedipine, Camptothecin, Paclitaxel and Curcumin …”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Biodegradability, biocompatibility, stability in the pH of 1–11 and negligible toxicity of NSs rendered them as safe drug carriers . To date, NSs have been used for delivery of various drugs such as Rilpivirine, Rosuvastatin calcium, Acyclovir, Norfloxacin, Anti‐restenotic Agent DB103, Doxorubicin and Captopril, Efavirenz, Nifedipine, Camptothecin, Paclitaxel and Curcumin …”
Section: Introductionmentioning
confidence: 99%
“…[12][13][14][15][16][17][18][19][20][21][22] Biodegradability, biocompatibility, stability in the pH of 1-11 and negligible toxicity of NSs rendered them as safe drug carriers. [23] To date, NSs have been used for delivery of various drugs such as Rilpivirine, [24,25] Rosuvastatin calcium, [26] Acyclovir, [27] Norfloxacin, [28] Anti-restenotic Agent DB103, [29] Doxorubicin and Captopril, [30] Efavirenz, [31] Nifedipine, [32] Camptothecin, [33] Paclitaxel [34] and Curcumin. [35] Diferuloylmethane (Curcumin), important bioactive component, is a natural phenolic compound derived from the spice turmeric (Curcuma longa).…”
Section: Introductionmentioning
confidence: 99%
“…CD-based nanosponges have been also developed for the delivery of Ripilvirine (RPV), an antiretroviral drug used on the treatment of HIV (Fig. 3) (Rao et al, 2018). Nanosponges provided an enhanced bioavailability of RPV in vitro and in vivo, compared with the administration of free antiviral and RPV:β-CD and RPV:HP-β-CD complexes.…”
Section: Modified Cyclodextrins In General Antiviral Formulationsmentioning
confidence: 99%
“…The solvent evaporation is one another method reported for loading active moieties into NS using organic solvents suitable for dissolving the active moiety. Finally, NS are added to the prepared active moiety dispersion and triturated until the solvent evaporates [47,73,74].…”
Section: Drug Loading Into Blank Nsmentioning
confidence: 99%