Investigation of DNA binding, DNA photocleavage, topoisomerase I inhibition and antioxidant activities of water soluble titanium(IV) phthalocyanine compounds

Özel, Arzu; Barut, Burak; Demirbaş, Ümit; Bıyıklıoğlu, Zekeriya

doi:10.1016/j.jphotobiol.2016.02.005

Cited by 53 publications

(36 citation statements)

References 41 publications

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“…Thermal melting temperature values may be utilized to verify the binding mechanism of DNA+compounds as intercalative or non‐intercalative binding mode. In general, thermal melting temperature rises to 8–12 o C with the intercalative binding modes, Whereas, groove binding compounds do not undergo a considerable change in thermal melting temperatures …”

Section: Resultsmentioning

confidence: 99%

Investigation of DNA‐Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5‐Trimethoxybenzyloxy Substituents

Arslantaş

Ağırtaş

2017

ChemistrySelect

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In this study, DNA‐binding activities of previously synthesized tetrakis(3,4,5‐trimethoxybenzyloxy)‐substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) have been chosen for the study. The interaction of synthesized tetrakis(3,4,5‐trimethoxybenzyloxy)‐substituted Zn(II) and Co(II) phthalocyanine compounds with CT‐DNA was investigated by using UV/Vis titrimetric method, fluorescence spectroscopy, cyclic voltammetry, thermal denaturation profile, gel electrophoresis and viscosty measurement in a Tris‐HCI buffer at pH 7.0. The results indicated that tetrakis(3,4,5‐trimethoxybenzyloxy)‐substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) can interact with CT‐DNA via intercalation binding mode.

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Section: Resultsmentioning

confidence: 99%

Investigation of DNA‐Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5‐Trimethoxybenzyloxy Substituents

Arslantaş

Ağırtaş

2017

ChemistrySelect

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“…It is well‐known that tyrosinase inhibitors possess antioxidant activity. 2,2‐Diphenyl‐1‐picrylhydrazyl (DPPH) accepts hydrogen atoms or an electron to be a diamagnetic molecule . DPPH assay is the most simple, rapid, and low costly method among the antioxidant assay, that is why it is a well‐known scavenger method .…”

Section: Resultsmentioning

confidence: 99%

“…2,2‐Diphenyl‐1‐picrylhydrazyl (DPPH) accepts hydrogen atoms or an electron to be a diamagnetic molecule . DPPH assay is the most simple, rapid, and low costly method among the antioxidant assay, that is why it is a well‐known scavenger method . DPPH gives a strong absorption band at 517 nm because of an odd electron and this method is based on reduction of absorbance.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Some Novel 2‐Substitutedbenzyl‐(4)7‐phenyl‐1H‐benzo[d]imidazoles in Mild Conditions as Potent Anti‐Tyrosinase and Antioxidant Agents

Doğan

Özel

Birinci

et al. 2016

Archiv der Pharmazie

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Novel 2-substitutedbenzyl-4(7)-phenyl-1H-benzo[d]imidazole compounds were synthesized and characterized. Although 2a and 2b were reported previously in the literature, 11 compounds were synthesized (nine of them were newly synthesized) and the tyrosinase inhibitory effects and antioxidant activities of these compounds were studied for the first time. All of the synthesized compounds displayed certain inhibitory effects on tyrosinase, with IC values ranging from 37.86 ± 0.24 to 75.81 ± 2.49 μM. Among the compounds, 2j exhibited similar tyrosinase inhibitory effect (IC = 37.86 ± 0.24 µM) to the positive control, kojic acid (IC = 21.93 ± 0.11 µM). Kinetic studies revealed it to act as non-competitive tyrosinase inhibitor with a K value of 50.2 µM. The antioxidant activities of the compounds were investigated by using in vitro antioxidant assays, including 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP). All of these results indicated that the compounds might have potential application as tyrosinase inhibitors.

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“…Formula 1 was used to calculate free radical scavenging effect. ) generation assay was used to determine the superoxide scavenging activity of the samples [20]. The assay mixture which has a total volume of 1 mL, was consist of riboflavin, NBT, methionine, EDTA, and the test samples (phosphate buffer, pH 7.8).…”

Section: Dpph Radical Scavenging Assaymentioning

confidence: 99%

Bioassay Guided Isolation of Active Compounds from Alchemilla barbatiflora Juz.

Renda¹,

Özel²,

Barut³

et al. 2017

Rec. Nat. Prod.

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Abstract:The aerial parts of Alchemilla L. species (Rosaceae) are used internally as diuretic, laxative, tonic and externally for wound healing in Turkish folk medicine. Antioxidant effects of the extracts, fractions and isolated compounds from the aerial parts of A. barbatiflora Juz. were investigated with following methods: 1,1-diphenyl-2-picryl-hydrazyl (DPPH), and superoxide radical scavenging (SOD), phosphomolibdenum-reducing antioxidant power (PRAP), ferric-reducing antioxidant power (FRAP) assays. In addition, tyrosinase, α-glucosidase and acetylcholinesterase inhibition activities of samples were analyzed. The methanol extract from the aerial parts of plant was consecutively fractionated into four subextracts; n-hexane, chloroform, and remaining water extracts. Further studies were carried out on the most active water subextract and the fractions obtained from water subextract with column chromatography. Phytochemical studies on active fractions of the water subextract led to the isolation of seven metabolites including catechin (1) and a catechin dimer; procyanidin B3 (2), a flavonol glucuronide; quercetin-3-O-β-D-glucuronic acid (miquelianin) (3) with flavonoid glycosides; quercetin-3-O-β-D-galactoside (hyperoside) (4), quercetin-3-O-β-D-arabinoside (guaiaverin) (5), kaempferol-3-O-β-Dxylopyranoside (6) and kaempferol-3-O-(6″-coumaroyl-β-D-glycoside) (tiliroside) (7). Their structures were elucidated by spectral techniques (1D and 2D NMR). The experimental data verified that procyanidin B3 displayed remarkable enzyme inhibitory activity among the whole isolated compounds.

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Investigation of DNA binding, DNA photocleavage, topoisomerase I inhibition and antioxidant activities of water soluble titanium(IV) phthalocyanine compounds

Cited by 53 publications

References 41 publications

Investigation of DNA‐Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5‐Trimethoxybenzyloxy Substituents

Investigation of DNA‐Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5‐Trimethoxybenzyloxy Substituents

Synthesis of Some Novel 2‐Substitutedbenzyl‐(4)7‐phenyl‐1H‐benzo[d]imidazoles in Mild Conditions as Potent Anti‐Tyrosinase and Antioxidant Agents

Bioassay Guided Isolation of Active Compounds from Alchemilla barbatiflora Juz.

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