Investigation of Electrochemical Oxidation Mechanism, Thermodynamic Parameters and Sensor Design for Analgesic and Relaxant Drug: Phenyramidol in Aqueous Medium by NH₂fMWCNT

Abstract

In this study, the electrochemical oxidation mechanism of phenyramidol HCl (PhA) was investigated in aqueous medium. An amine functionalized multi walled carbon nanotube (NH 2 fMWCNT) modified glassy carbon electrode (GCE) was used as a sensitive and fast sensor for the determination of PhA. Scanning electron microscopy (SEM) with Energy Dispersive X-Ray (EDX), analysis and electrochemical impedance spectroscopy (EIS) were applied for investigation of surface morphology. Cyclic voltammetry (CV) differential pulse voltammetry (DPV) and adsorptive stripping differential pulse voltammetry (AdSDPV) methods were employed to compare the redox responses of PhA on the surface of bare and modified electrode with NH 2 fMWCNTs. The results showed a considerable enhancement in the peak current of PhA with AdSDPV. A linear calibration curve was obtained in the concentration ranges of 0.8-100 μM, with a detection limit of 6.13 × 10 −8 M and 2.78 × 10 −8 M from peaks 1 and 2, respectively. The proposed procedure was easily and sensitively applied for the determination of PhA in human serum samples and tablet dosage form with satisfactory recovery value (recovery >99%).

Electrochemical Impedance Spectroscopic Detection of E.coli with Machine Learning

“…EIS electrode.-To enhance the electrochemical properties, a nanocomposite material comprised of multiwall carbon nanotubes (MWCNTs), Prussian blue (PB) and gold nanoparticles (AuNPs) was used. [40][41][42][43][44] First, 4 mg of MWCNTs was dispersed in 40 mL of FeCl 3 solution (0.01 mol L −1 ), and 40 mL of potassium ferricyanide solution (0.01 mol L −1 ) was added drop by drop to obtain PB-MWCNTs with good stability, which were further prepared by ultrasonication for 5 h. After centrifugation, the precipitate was dispersed into 4 mL of chitosan aqueous solution (0.05%). The excess chitosan was removed by centrifugation, and the solution was z E-mail: hui.yu@sjtu.edu.cn stirred with 8 mL of gold colloid (0.1 g L −1 ) to obtain AuNPs-PB-MWCNTs, after which the nanocomposites were dispersed into 2 mL of deionized water to obtain AuNPs-PB-MWCNT composites.…”

Highly Sensitive and Selective Electrochemical Sensor Based on Polyglycine Modified Glassy Carbon Electrode for Simultaneous Determination of Amlodipine and Ramipril from Biological Samples

“…Electroanalytical techniques are very elegant methods due to their instrumental simplicity, high sensitivity, short analysis time and low cost. [21][22][23][24] However, using ordinary electrodes (Pt, Au, carbon paste, and graphite) bare electrodes to electrochemical detection of many molecules entail sometimes restrictions namely instable and weak electrochemical signal, high oxidation overpotential, and overlap the responses signal of analytes. 25 Nevertheless, the possibility of modifying the surface of electrochemical-based sensors with new conductive materials can significantly improve the sensitivity of the response signal and promote the electron transfer kinetics of analyte in terms of improved current response and reduced overpotential with respect to the bare electrode.…”