Investigation of Electrostatic Properties of Pharmaceutical Powders Using Phase Doppler Anemometry

Beleca, Radu; Abbod, Maysam F.; Balachandran, W.; Miller, Paul R.

doi:10.1109/tia.2010.2045332

Cited by 15 publications

(11 citation statements)

References 19 publications

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“…It is important to note that the simulation tests were performed using a very challenging assumption that the magnitude of particle charge was uniformly distributed from 0 to a saturation level for different size fractions. Such a situation is very unlikely to occur in the actual measurements where the majority of particles would likely fall into much more narrow charge distribution, most probably close to the lower end of the charge range spectrum [8], [9]. In such majority of cases, the measurement bias would be considerably smaller than the one presented in this paper due to smaller variation of the amplitude of particle motion.…”

Section: Discussionmentioning

confidence: 70%

“…An experimental study conducted by Kulon et al [8] successfully used the PCSA to simultaneously measure the size and charge distribution of aerosol droplets from a Medic-Aid Sidestream nebulizer in a dc electric field. The work was further extended by Beleca et al [9] to the measurement of the charge and size distribution of non-spherical pharmaceutical powders. Furthermore, the PCSA operated in an oscillatory electric field has been implemented [7], which offers better performance than the version using dc field excitation [10].…”

Section: Introductionmentioning

confidence: 98%

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Three-Dimensional Numerical Study of Particle Trajectory in Particle Charge and Size Analyzer Considering the Effects of System Parameters

Zhang

Kulon

2019

IEEE Access

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In this study, for the purpose of the optimization of the measurement system performance, a three-dimensional numerical model of the particle charge and size analyzer (PCSA) is presented. The PCSA is capable of simultaneous particle size and charge measurement using phase Doppler anemometry. Numerical simulations of particle transport under the influence of the square-wave excitation field have been carried out to identify the optimal PCSA system configurations, improve the particle detection rate, and minimize the measurement bias due to experimental conditions. For the first time, the three-dimensional (3-D) numerical model was used to study the effects of excitation frequency, magnitude of the electric field, and particle inlet velocity on the particle detection rate and charge and size measurement bias. The airflow and the particle motion in the measurement cell were investigated using commercial FLUENT 14.5 software and the particle detection and validation algorithm was implemented in MATLAB. The particle phase was modelled using the Lagrangian approach. The effect of the electric field on particle trajectories was analyzed by solving a coupled system of the electric field and particle transport equations using the User-Defined-Functions (UDFs) in FLUENT. The model was validated by comparing the numerical results with reported experimental data. This 3-D numerical simulation provides a valuable insight into various tradeoffs between the detection rate of particles with different electrical mobility levels and the PCSA parameters. The numerical simulation results demonstrate that the reduction of the measurement bias of particle charge and size distribution can be achieved while maintaining high particle detection percentage by an appropriate selection of system parameters, leading to a more representative profile of measured aerosols. It is shown that the optimal ranges of the excitation frequency, magnitude of electric field, and particle velocity at inlet are between 40 -50 Hz, 0.3 -0.4 MV/m, and 0.01 -0.03 m/s, respectively.INDEX TERMS Medical aerosol, particle charge and size measurement, phase Doppler anemometry (PDA), numerical simulation.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 98%

Three-Dimensional Numerical Study of Particle Trajectory in Particle Charge and Size Analyzer Considering the Effects of System Parameters

Zhang

Kulon

2019

IEEE Access

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“…The total charge of the powder is then measured by recording the charge between the charged surface of the inner ball/ well and the ground with an electrometer. Other techniques for assessment of electrostatic charging include phase Doppler anemometry (Beleca et al, 2010). Such techniques can be also combined with AFM results to gain information about correlations between charging and particulate characteristics.…”

Section: Electrical Force Measurementsmentioning

confidence: 99%

Characterisation of dry powder inhaler formulations using atomic force microscopy

Weiss

McLoughlin

Cathcart

2015

International Journal of Pharmaceutics

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A B S T R A C TInhalation formulations are a popular way of treating the symptoms of respiratory diseases. The active pharmaceutical ingredient (API) is delivered directly to the site of action within the deep lung using an inhalation device such as the dry powder inhaler (DPI).The performance of the formulation and the efficiency of the treatment depend on a number of factors including the forces acting between the components. In DPI formulations these forces are dominated by interparticulate interactions. Research has shown that adhesive and cohesive forces depend on a number of particulate properties such as size, surface roughness, crystallinity, surface energetics and combinations of these. With traditional methods the impact of particulate properties on interparticulate forces could be evaluated by examining the bulk properties. Atomic force microscopy (AFM), however, enables the determination of local surface characteristics and the direct measurement of interparticulate forces using the colloidal probe technique. AFM is considered extremely useful for evaluating the surface topography of a substrate (an API or carrier particle) and even allows the identification of crystal faces, defects and polymorphs from high-resolution images. Additionally, information is given about local mechanical properties of the particles and changes in surface composition and energetics. The assessment of attractive forces between two bodies is possible by using colloidal probe AFM.This review article summarises the application of AFM in DPI formulations while specifically focussing on the colloidal probe technique and the evaluation of interparticulate forces.2015 Elsevier B.V. All rights reserved.

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“…Currently, there are no pharmacopoeial methods used in the characterization of particle charges [30]. However, recently there has been an increase in the research into the characterization of the electrostatic properties of powders [31]. The electrostatic charging observed in powder samples occur as a result of contacts and collisions between individual particles and particle-surface collisions in a gaseous environment [32].In this study, a novel equipment developed in the Wolfson Centre, University of Greenwich [33] is used to assess the charge properties and charge distribution of freeze dried particulate materials.…”

Section: Introductionmentioning

confidence: 99%

Freeze-dried crystalline dispersions: Solid-state, triboelectrification and simultaneous dissolution improvements

Adebisi

Kaialy

Hussain

et al. 2021

Journal of Drug Delivery Science and Technology

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Investigation of Electrostatic Properties of Pharmaceutical Powders Using Phase Doppler Anemometry

Cited by 15 publications

References 19 publications

Three-Dimensional Numerical Study of Particle Trajectory in Particle Charge and Size Analyzer Considering the Effects of System Parameters

Three-Dimensional Numerical Study of Particle Trajectory in Particle Charge and Size Analyzer Considering the Effects of System Parameters

Characterisation of dry powder inhaler formulations using atomic force microscopy

Freeze-dried crystalline dispersions: Solid-state, triboelectrification and simultaneous dissolution improvements

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