Investigation of emtricitabine-associated skin pigmentation and safety in HIV-1-infected Japanese patients

Shirasaka, Takuma; Tadokoro, Taketsugu; Yamamoto, Yasuyuki; Fukutake, Katsuyuki; Kato, Yukihiko; Odawara, Takashi; Nakamura, Toshio; Ajisawa, Atsushi; Negishi, Masayoshi

doi:10.1007/s10156-011-0222-5

Cited by 9 publications

(1 citation statement)

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“…Histopathological findings of the skin pigmentation show increasing of melanin in the basal layer of epidermis similar to lentigo solaris. In the previous report, emtricitabine-associated skin pigmentation occurred 3.9% of Japanese patients [1], however, very few case reports have been seen. Of note, our case showed more than fifty pigmented macules on his palms and soles, many of which regressed spontaneously or turned pale within 11 months.…”

Section: Discussionmentioning

confidence: 99%

Eruptive pigmented patches in a patient with HIV infection under HAART

Nakamura-Wakatsuki¹,

Yamamoto²

2013

Our Dermatol Online

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Introduction: Highly active antiretroviral therapy (HAART) is a standard treatment for HIV-infected patients. It has been reported that emtricitabine rarely induces skin pigmentation in the palms and soles. We herein report a Japanese case which presented a number of small pigmented patches on the acral sites. Main observation: A 58-year-old Japanese man complained about multiple brownish skin pigmentations on his both palms and soles after 2 months of HAART therapy. Dermatoscopic observation showed a homogeneous light brown pattern. In spite of continuance of HAART, these lesions spontaneously regressed within 11 months. Conclusion:We should know about the eruptive pigmented patches as an adverse effect under HAART with HIV infected patients.

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Section: Discussionmentioning

confidence: 99%