Investigation of graphene‐on‐metal substrates for SPR‐based sensor using finite‐difference time domain

Said, Fairus Atida; Menon, P. Susthitha; Rajendran, V.; Shaari, Sahbudin; Majlis, Burhanuddin Yeop

doi:10.1049/iet-nbt.2017.0051

Cited by 23 publications

(8 citation statements)

References 26 publications

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“…As shown in Fig 1 , borosilicate glass (BSG) substrate with refractive index of 1.503 and thickness of 795 nm was used and the simulated dielectric medium was set as air (refractive index, n = 1.00). The Kretschmann configuration in FDTD software using angular interrogation technique shows the XY, XZ and YZ view as in Fig 1 [ 32 ]. Further, numerical analysis was conducted with changes of optical parameter for an SPR-based sensor with 50 nm-thick nano-laminated gold film.…”

Section: Methodsmentioning

confidence: 99%

Urea and creatinine detection on nano-laminated gold thin film using Kretschmann-based surface plasmon resonance biosensor

et al. 2018

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This work investigates the surface plasmon resonance (SPR) response of 50-nm thick nano-laminated gold film using Kretschmann-based biosensing for detection of urea and creatinine in solution of various concentrations (non-enzymatic samples). Comparison was made with the presence of urease and creatininase enzymes in the urea and creatinine solutions (enzymatic samples), respectively. Angular interrogation technique was applied using optical wavelengths of 670 nm and 785 nm. The biosensor detects the presence of urea and creatinine at concentrations ranging from 50–800 mM for urea samples and 10–200 mM for creatinine samples. The purpose of studying the enzymatic sample was mainly to enhance the sensitivity of the sensor towards urea and creatinine in the samples. Upon exposure to 670 nm optical wavelength, the sensitivity of 1.4°/M was detected in non-enzymatic urea samples and 4°/M in non-enzymatic creatinine samples. On the other hand, sensor sensitivity as high as 16.2°/M in urea-urease samples and 10°/M in creatinine-creatininase samples was detected. The enhanced sensitivity possibly attributed to the increase in refractive index of analyte sensing layer due to urea-urease and creatinine-creatininase coupling activity. This work has successfully proved the design and demonstrated a proof-of-concept experiment using a low-cost and easy fabrication of Kretschmann based nano-laminated gold film SPR biosensor for detection of urea and creatinine using urease and creatininase enzymes.

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Section: Methodsmentioning

confidence: 99%

Urea and creatinine detection on nano-laminated gold thin film using Kretschmann-based surface plasmon resonance biosensor

et al. 2018

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“…As the refractive index at the sensing region changed due to increase in urea concentration, shift in resonance angle were recorded in SPR spectra. Sensorgram, linearity, repeatability and sensitivity analyses of the 50 nm-thick nanolaminated gold film sensor for urea detection were investigated based on the SPR spectra obtained (Menon et al 2018;Said et al 2017).…”

Section: Experimental Methodsmentioning

confidence: 99%

High Sensitivity Au-based Kretschmann Surface Plasmon Resonance Sensor for Urea Detection

Menon¹,

Said²,

Gan³

et al. 2019

JSM

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Kretschmann-based Surface Plasmon Resonance (SPR) optical sensor was applied to detect the presence of kidney wastes such as urea in solutions. To enhance the sensitivity of the SPR sensor, nanolaminated gold film (thickness of 50 nm) was used. In this work, the SPR response to urea in various concentrations were measured and investigated using optical wavelengths of 670 nm and 785 nm. The signals were compared between pure urea solution versus mixed solution in the presence of the 0.227 µmol urease enzyme. The proposed mixed solution is to eliminate doping and gel entrapment process for enzyme immobilization in conventional method. Angular interrogation technique was used to measure the sensor performance in urea detection using pure and mixed solutions with urea concentration of 0-800 mM. Upon exposure to mixed solution using 785 nm optical wavelength, the nanolaminated gold film exhibited higher SPR sensitivity as much as 7.8 M-1 than a pure urea solution (1.4 M-1). The coupling activity between urea and urease molecules in the mixed solution near the nanolaminated gold film surface lead to sensitivity enhancement. Angle shifting of mixed solution on 50 nm-thick nanolaminated gold film using 670 nm optical wavelength was greater by ~50% compared to 785 nm. Sensorgram data shows a steady and linear increment in SPR incident angle shifting when urea concentration increased. To the best of our knowledge, this is the first time that Kretschmann-based SPR has been used for urea sensing at 670 nm and 785 nm optical wavelengths.

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“…Prior to the deposition and characterization of an SPR biosensor, ZnO is optimized using numerical methods to achieve a high-performance sensor. This can be achieved by simulation of the SPR curve with different thicknesses of the ZnO layer using Finite Difference Time-Domain (FDTD) method from Lumerical [55][56][57]. As the thickness of the ZnO increases, the FWHM and resonance angle of the SPR signal becomes larger which would affect sensor reliability and sensitivity.…”

Section: Performance Parameter Of Spr Biosensormentioning

confidence: 99%

ZnO for performance enhancement of surface plasmon resonance biosensor: a review

Mei

Menon

Hegde³

2020

Mater. Res. Express

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This paper reviews Kretschmann-based SPR sensor utilizing ZnO thin films and nanostructures for performance enhancement. The advancement in surface plasmon resonance technology relies on low-cost, high sensitivity and high selectivity sensor. Metal oxide has been incorporated in SPR sensor to be used for detection of biological and chemical compounds. ZnO as one of the metal oxides is an attractive material due to its unique physical and optical properties. Numerous techniques for fabrication and characterization of ZnO on SPR gold substrate have been studied. The mechanism for gas and biomolecules detection depends on their interaction with ZnO surface, which is mainly attributed to the high isoelectric point of ZnO. There are several types of ZnO nanostructures which have been employed for SPR application based on the Kretschmann configuration. In future, the thin film and nanostructures of ZnO have potential applications for miniature design, robust, high sensitivity, and low-cost portable type of SPR biosensor to be used for on-site testing in real-time and label-free manner.

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Investigation of graphene‐on‐metal substrates for SPR‐based sensor using finite‐difference time domain

Cited by 23 publications

References 26 publications

Urea and creatinine detection on nano-laminated gold thin film using Kretschmann-based surface plasmon resonance biosensor

Urea and creatinine detection on nano-laminated gold thin film using Kretschmann-based surface plasmon resonance biosensor

High Sensitivity Au-based Kretschmann Surface Plasmon Resonance Sensor for Urea Detection

ZnO for performance enhancement of surface plasmon resonance biosensor: a review

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