ZnO for performance enhancement of surface plasmon resonance biosensor: a review

Mei, Gan Siew; Menon, P. Susthitha; Hegde, Gurumurthy

doi:10.1088/2053-1591/ab66a7

Cited by 84 publications

(43 citation statements)

References 119 publications

(104 reference statements)

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“…In this work, we evaluate the sensitivity of the sensor from the dielectric medium of air with refractive index of n = 1 to the refractive index of water, n =1.33. The larger the SPR curve shift of two different mediums, the higher the sensitivity value and thus the performance of the sensor is greater [12].…”

Section: Methodsmentioning

confidence: 99%

Characterisation of nano-thin film GO/TiO2 layers for Kretschmann-based surface plasmon resonance visible sensing using FDTD method

Khairulazdan¹,

Mohamed²,

Berhanuddin³

et al. 2021

Optica Applicata

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Kretschmann-based surface plasmon resonance (K-SPR) is suitable for biomolecular sensing which provides label-free and quick detection results with real-time analysis. In this work, we have investigated the effect of graphene oxide (GO) with titanium dioxide (TiO2) thin films that are placed in hybrid above metal layers such as gold (Au), silver (Ag) and copper (Cu) with the presence of chromium (Cr) as an adhesive layer. The thickness of the Au, Ag and Cu metal thin films were optimized to 40, 30 and 30 nm, respectively, with a fixed thickness of GO of 2 nm and TiO2 of 1.9 nm. The sensing was evaluated for SPR excitation at three different visible wavelengths of 633, 670 and 785 nm. The performance of sensing was analyzed based on the reflectance intensity and full-width at half-maximum (FWHM) of the spectrum using the finite-difference time-domain (FDTD) method. The sensitivity was calculated for analyte sensing in dielectric mediums of air versus water. The sensitivity increment percentage (%ΔS) was determined when comparing analyte detection using Cr/metal and Cr/metal/GO/TiO2 sensor structures. The highest sensitivity of 94.51 deg/RIU was achieved for Cr/Cu/GO/TiO2 K-SPR sensor at 633 nm wavelength.

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Section: Methodsmentioning

confidence: 99%

Characterisation of nano-thin film GO/TiO2 layers for Kretschmann-based surface plasmon resonance visible sensing using FDTD method

Khairulazdan¹,

Mohamed²,

Berhanuddin³

et al. 2021

Optica Applicata

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“…At this condition, the electrons start to resonate triggering the generation of SPW on the metal-dielectric interface where a sharp loss peak called the SPR point appears. The SPR point is extremely responsive to the refractive index (RI) of the surrounding medium where a minor change in RI of the dielectric (sensing) medium shifts the SPR point to a new state [69].…”

Section: Principle Of Spr Phenomenamentioning

confidence: 99%

Hybrid Heterostructures for SPR Biosensor

Anower¹,

Rahman²,

Rahman³

2021

Biosensors - Current and Novel Strategies for Biosensing

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Surface plasmon resonance (SPR) based biosensors have been enormously studied in the last decade for their better sensitivity. In recent years hybrid heterostructures are getting popularity to implement these SPR biosensors for their superior sensing capability. This chapter demonstrates the details of SPR technology with two recently studied prism-based hybrid heterostructures. These heterostructures are made up of conventional SPR biosensors with two additional layers of recently invented transition metal dichalcogenides, platinum di-selenide (PtSe2), and highly sensitive 2D material, tungsten di-sulfide (WS2). Angular interrogation method is discussed to investigate the sensing capabilities of the sensors which prove the superiority of the Ag-PtSe2-WS2 structure. The sensing capability of this structure has been found at least 1.67 times higher than that of the conventional non-hybrid structures, respectively, with comparable FOM and QF. A comparison table has been provided at the end of this chapter which also shows the impressive performance of the hybrid heterostructures for SPR biosensors. Proper demonstration with a suitable example of this chapter will emphasize the potential use of hybrid heterostructure based SPR biosensors in prospective medical diagnostics and biomedical detection applications.

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“…The use of ZnO nanostructures in biosensing devices has been the subject of several review articles over the last few years, emphasizing its unique properties in different types of devices (e.g., electrical, electrochemical, and optical biosensors) targeting different analytes [1,2,[44][45][46][47]. Notwithstanding, the focus on its PL as a possible transduction mechanism is far less surveyed.…”

Section: Introductionmentioning

confidence: 99%

ZnO Transducers for Photoluminescence-Based Biosensors: A Review

et al. 2022

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Zinc oxide (ZnO) is a wide bandgap semiconductor material that has been widely explored for countless applications, including in biosensing. Among its interesting properties, its remarkable photoluminescence (PL), which typically exhibits an intense signal at room temperature (RT), arises as an extremely appealing alternative transduction approach due to the high sensitivity of its surface properties, providing high sensitivity and selectivity to the sensors relying on luminescence output. Therefore, even though not widely explored, in recent years some studies have been devoted to the use of the PL features of ZnO as an optical transducer for detection and quantification of specific analytes. Hence, in the present paper, we revised the works that have been published in the last few years concerning the use of ZnO nanostructures as the transducer element in different types of PL-based biosensors, namely enzymatic and immunosensors, towards the detection of analytes relevant for health and environment, like antibiotics, glucose, bacteria, virus or even tumor biomarkers. A comprehensive discussion on the possible physical mechanisms that rule the optical sensing response is also provided, as well as a warning regarding the effect that the buffer solution may play on the sensing experiments, as it was seen that the use of phosphate-containing solutions significantly affects the stability of the ZnO nanostructures, which may conduct to misleading interpretations of the sensing results and unreliable conclusions.

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ZnO for performance enhancement of surface plasmon resonance biosensor: a review

Cited by 84 publications

References 119 publications

Characterisation of nano-thin film GO/TiO2 layers for Kretschmann-based surface plasmon resonance visible sensing using FDTD method

Characterisation of nano-thin film GO/TiO2 layers for Kretschmann-based surface plasmon resonance visible sensing using FDTD method

Hybrid Heterostructures for SPR Biosensor

ZnO Transducers for Photoluminescence-Based Biosensors: A Review

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