Investigation of key miRNAs and potential mechanisms in non-small cell lung cancer development from chronic obstructive pulmonary disease

Denkçeken, Tuba; Pala, Elif

doi:10.4149/gpb_2019042

Cited by 6 publications

(5 citation statements)

References 32 publications

(33 reference statements)

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“…hsa-mir-31 is an important protective factor of the epithelial barrier [ 24 ] and has also been recognized as a cancer biomarker [ 25 , 26 ]. hsa-mir-497 and has-mir-29c suppress various cancers, inhibiting the proliferation and growth of cancer [ 27 – 30 ]. hsa-mir-486 is a migration suppressor of various tumors and plays an important role in regulating epithelial-mesenchymal transition (EMT) [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma

Wen

et al. 2023

BMC Oral Health

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Background Oral squamous cell carcinoma (OSCC) is one of the malignant tumors with a poor prognosis. Periodontitis (PD is considered a high-risk factor for OSCC, but the genetic mechanism is rarely studied. This study aims to link OSCC and PD by identifying common differentially expressed miRNAs (Co-DEmiRNAs), their related genes (Hub genes), transcription factors (TFs), signaling pathways, enrichment functions, and compounds, and searching for genetic commonalities. Methods The miRNAs expression datasets of OSCC and PD were searched from the GEO database. The miRNA and related crosstalk mechanism between OSCC and PD was obtained through a series of analyses. Results hsa-mir-497, hsa-mir-224, hsa-mir-210, hsa-mir-29c, hsa-mir-486-5p, and hsa-mir-31are the top miRNA nodes in Co-DEmiRNA-Target networks. The most significant candidate miRNA dysregulation genes are ZNF460, FBN1, CDK6, BTG2, and CBX6, while the most important dysregulation TF includes HIF1A, TP53, E2F1, MYCN, and JUN. 5-fluorouracil, Ginsenoside, Rh2, and Formaldehyde are the most correlated compounds. Enrichment analysis revealed cancer-related pathways and so on. Conclusions The comprehensive analysis reveals the interacting genetic and molecular mechanism between OSCC and PD, linking both and providing a foundation for future basic and clinical research.

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Section: Discussionmentioning

confidence: 99%

Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma

Wen

et al. 2023

BMC Oral Health

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“…These pathways were down-regulated in COPD and up-regulated in NSCLC. The aforementioned miRNAs have been demonstrated to be associated with COPD and lung cancer [28][29][30][31][32][33][34][35][36][37]. The point is that though miRNAs' roles are known in COPD and NSCLC, understanding their functions in common significant pathways may shed light on the pathogenic mechanism of both diseases and develop new therapeutic targets.…”

Section: Discussionmentioning

confidence: 99%

Identification of common microRNA between COPD and non-small cell lung cancer through pathway enrichment analysis

Fathinavid¹,

Ghobadi

Najafi³

et al. 2021

BMC Genom Data

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Background Different factors have been introduced which influence the pathogenesis of chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC). COPD as an independent factor is involved in the development of lung cancer. Moreover, there are certain resemblances between NSCLC and COPD, such as growth factors, activation of intracellular pathways, as well as epigenetic factors. One of the best approaches to understand the possible shared pathogenesis routes between COPD and NSCLC is to study the biological pathways that are activated. MicroRNAs (miRNAs) are critical biomolecules that implicate the regulation of several biological and cellular processes. As such, the main goal of this study was to use a systems biology approach to discover common dysregulated miRNAs between COPD and NSCLC, one that targets most genes within common enriched pathways. Results To reconstruct the miRNA-pathways for each disease, we used the microarray miRNA expression data. Then, we employed “miRNA set enrichment analysis” (MiRSEA) to identify the most significant joint miRNAs between COPD and NSCLC based on the enrichment scores. Overall, our study revealed the involvement of the targets of miRNAs (such as has-miR-15b, hsa-miR-106a, has-miR-17, has-miR-103, and has-miR-107) in the most important common biological pathways. Conclusions According to the promising results of the pathway analysis, the identified miRNAs can be utilized as the new potential signatures for therapy through understanding the molecular mechanisms of both diseases.

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“…Epigenetic regulators, such as DNA methylation and certain miRNA circuits (miR-21, miR-200b, miR-210, and miR-let7c), are associated with lung cancer in COPD patients, leading to a decreased expression of downstream genes such as PTEN, MARCKs, TPM-1, PDCD4, SPRY-2, ETS-1, ZEB-2, FGFRL-1, EFNA-3, and k-RAS together with P53 [161]. Other miRNAs, i.e., hsa-miR-497-5p and hsa-miR-130b-5p, were recently shown to be higher expressed in COPD patients who developed non-small-cell lung cancer [162].…”

Section: Genetic and Epigenetic Factors Associated With Lung Cancer I...mentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease: Epidemiology, Biomarkers, and Paving the Way to Lung Cancer

Szalontai

Gémes

Furák

et al. 2021

JCM

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Chronic obstructive pulmonary disease (COPD), the frequently fatal pathology of the respiratory tract, accounts for half a billion cases globally. COPD manifests via chronic inflammatory response to irritants, frequently to tobacco smoke. The progression of COPD from early onset to advanced disease leads to the loss of the alveolar wall, pulmonary hypertension, and fibrosis of the respiratory epithelium. Here, we focus on the epidemiology, progression, and biomarkers of COPD with a particular connection to lung cancer. Dissecting the cellular and molecular players in the progression of the disease, we aim to shed light on the role of smoking, which is responsible for the disease, or at least for the more severe symptoms and worse patient outcomes. We summarize the inflammatory conditions, as well as the role of EMT and fibroblasts in establishing a cancer-prone microenvironment, i.e., the soil for ‘COPD-derived’ lung cancer. We highlight that the major health problem of COPD can be alleviated via smoking cessation, early diagnosis, and abandonment of the usage of biomass fuels on a global basis.

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Investigation of key miRNAs and potential mechanisms in non-small cell lung cancer development from chronic obstructive pulmonary disease

Cited by 6 publications

References 32 publications

Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma

Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma

Identification of common microRNA between COPD and non-small cell lung cancer through pathway enrichment analysis

Chronic Obstructive Pulmonary Disease: Epidemiology, Biomarkers, and Paving the Way to Lung Cancer

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