Laser milling of industrial materials like ceramics, dielectrics and metals is of significant commercial interest for microfabrication of micro-moulds and other micro-system devices. 2.5D laser machined structures were generated in alumina, tungsten and steel substrates using a nanosecond copper vapour laser (511nm) at 10 kHz. Preliminary results in fused silica, alumina and steel are also presented from a high repetition rate amplified mode-locked picosecond Nd:vanadate laser. It is shown that high quality surface finish can be achieved with both laser types; for example, average surface roughness, Ra ~ 300nm has been demonstrated in steel. Fused silica could only be processed with picosecond laser pulses. Volume removal rates are analysed, which are especially high for difficult materials like tungsten (~0.1mm 3 /min) and are greater compared to other milling technology like micro-EDM. Surface roughness measurements in these materials using white light interferometry are reported along with SEM analysis.