Investigation of phytochemicals and anti-convulsant activity of the plant Coleus amboinicus (lour.)

Majumder, Pulak; Bhattacharjee, Prasenjit

doi:10.4103/0973-8258.120223

Cited by 11 publications

(4 citation statements)

References 4 publications

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“…The antioxidant activity of torbangun leaves extract in this study was 306.279 ppm/1ppm vitamin C. Referring to the research of Suryowati et al (2015b), the extract produced by the maceration method showed the DPPH IC 50 antioxidant activity of 297.942 ppm. Another study reported that the DPPH IC 50 ethanol extract of torbangun's leaves from maceration method was 207.57 ppm/1ppm vitamin C (Bhattacharjee & Majumder 2013). The variation in antioxidant activity could be possibly caused by differences in the types of flavonoid contents due to differences in the growing process and extraction methods.…”

Section: Profile Of Torbangun Leaves Extractmentioning

confidence: 99%

Effects of Torbangun Leaves(Coleus amboinicus Lour) Extract on Blood Glucose and Super Oxide Dismutase Activity in Hyperglycemic Rats

et al. 2019

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This research aimed to analyze the yield of torbangun extract, flavonoid content, and antioxidant activity of TE-S and its effect on the activity of SOD enzymes and blood glucose level in hyperglycemic rats as a DM animal model. The water content of simplicia was measured by the gravimetric method. The antioxidant activity of TE-S was determined using the DPPH method, while the total flavonoid was measured using spectrophotometry. The study was a completely randomized design using 25 Sprague Dawley rats. Rats were divided into four groups, namely NG (negative control, hyperglycemic rats), N (normal rats), HIM (control of metformin drugs 62.5 mg/kg of BW), and HIT (TE-S 620 mg/kg of BW). The treatment was carried out for 14 days. FBG levels were taken on day 0, 4, 7, 11, and 14, measured using a glucometer, while blood serum SOD levels were measured using ELISA. The study showed the water content of torbangun simplicia was 7.99% and TE-S yield from simplicia was 4.69%. TE-S contains total flavonoids of 3.91% and antioxidant activity (IC 50) of 306.28 ppm with a standard of 1 ppm vitamin C. TE-S treatment significantly decreased FBG (p=0.005, α=0.01) and increased SOD levels in hyperglycemic rats. TE-S has the potential to increase blood serum SOD levels by contributing to the availability of antioxidants and decreasing blood glucose levels in hyperglycemic rats.

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Section: Profile Of Torbangun Leaves Extractmentioning

confidence: 99%

Effects of Torbangun Leaves(Coleus amboinicus Lour) Extract on Blood Glucose and Super Oxide Dismutase Activity in Hyperglycemic Rats

et al. 2019

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“…A study has reported that antihyperglycemic and anti-hyperlipidemic activity of torbangun in Streptozotocin induced diabetic rats [8]. Significant anticonvulsant activity of C. amboinicus in Swiss Albino Mice was also reported and the presence of flavonoids, alkaloids, and saponin in the extract may be responsible for this activity [9]. Plectranthus amboinicus Lour also had a cytotoxic effect on HeLa cells [10].…”

Section: Introductionmentioning

confidence: 99%

Methanol Extract of Coleus amboinicus (Lour) Exhibited Antiproliferative Activity and Induced Programmed Cell Death in Colon Cancer Cell WiDr

Laila

Fardiaz

Yuliana

et al. 2020

International Journal of Food Science

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Coleus amboinicus(Lour) (CA) has been reported to possess many pharmacological activities. In this study, evaluation of cytotoxicity using brine shrimp lethality bioassay and MTT assay using WiDr cell lines was carried out. The expression of several genes responsible for programmed cell death of the methanol extract of CA was also investigated. The morphology of the cells undergoing apoptosis was detected using Hoechst staining assay. The gene expression of BAX, BCL2, P53, Caspase 1, 7, 8, and 9 of treated samples with different concentrations (10, 15, 25 & 50 µg/ml) were measured with RT PCR. The phytochemical profiles were investigated using LC MS. The results showed that the lethality concentration (LC50) of methanol extract using brine shrimp was 34.545 µg/ml and the extract exhibited good antiproliferative activity against cancer cells WiDr with IC50 value (8.598 ± 2.68 µg/ml) as compared to standard drug 5-fluorouracil (IC50 value 1.839 ± 0.03 µg/ml). There was apoptotic evidences from the morphology of treated cells. The expressions of BAX,P53, and Caspase 9 were upregulated in lower concentration of the extract (10 and 15 µg/ml) but downregulated in higher concentration (25 and 50 µg/ml). BCL2 as anti-apoptotic gene was downregulated in all concentrations. Caspase 1 and Caspase 7 were upregulated in high concentration (25 and 50 µg/ml), but downregulated in lower concentrations. These data provide a mode of cell death for the methanol extract of CA in low concentrations corresponding to apoptosis with intrinsic pathway. Many valuable compounds identified including caffeic acid, rosmarinic acid, malic acid, eicosapentanoic acid, benserazide, alpha-linolenic acid, betaine, Salvanolic B, 4-hydroxibenzoic acid and firulic acid have been previously reported as being active agents against many cancer cells. This study suggested that CA might become an effective ingredient for health-beneficial foods to prevent colon cancer.

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“…Recently, two flavonoid compounds isolated from R. equisetiformis were reported to have potential analgesic activity[ 12 ]. Flavonoids, triterpenes saponins are known to either produce inhibitory, and/or stimulatory effects on convulsions[ 13 14 ]. In addition to its antiinflammatory activity, R. equisetiformis has also been reported to have membrane stabilizing properties of which phenyl ethanoid glycosides of this plant, russectinol and russeliaoside, were identified as its active constituents[ 11 15 ].…”

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confidence: 99%

In vivo antimalarial activities of russelia equisetiformis in plasmodium berghei infected mice

Ojurongbe¹,

Ojo²,

Adefokun³

et al. 2015

Indian J Pharm Sci

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The rising problem of resistance to most commonly used antimalarials remains a major challenge in the control of malaria suggesting the need for new antimalarial agents. This work explores the antiplasmodial potential of ethanol extract of Russelia equisetiformis in chloroquine Plasmodium berghei infected mice. Swiss albino mice were intraperitoneally infected with chloroquine-resistant P. berghei (ANKA). Experimental mice were treated for four days consecutively with graded doses of plant extracts and standard antimalarial drugs (artesunate and chloroquine) at a dose of 10 mg/kg body weight used as control. The extract showed a dose-dependent activity in the chemosuppression of P. berghei parasites by 31.6, 44.7, 48.4 and 86.5% at doses of 100, 200, 400 and 800 mg/kg, while chloroquine (10 mg/kg) and artesunate produced 59.4 and 68.4%, respectively. The extract showed a significant decrease in parasitaemia (P<0.05). The level of parasitemia and decrease in weight in all the treated groups was significantly lower (P<0.05) compared with the infected but untreated mice. The plant extract was devoid of toxicity at the highest dose tested (5000 mg/kg). The study concluded that the ethanol extract of R. equisetiformis possesses antimalarial effect, which supports the folk medicine claim of its use in the treatment of malaria.

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Investigation of phytochemicals and anti-convulsant activity of the plant Coleus amboinicus (lour.)

Cited by 11 publications

References 4 publications

Effects of Torbangun Leaves(Coleus amboinicus Lour) Extract on Blood Glucose and Super Oxide Dismutase Activity in Hyperglycemic Rats

Effects of Torbangun Leaves(Coleus amboinicus Lour) Extract on Blood Glucose and Super Oxide Dismutase Activity in Hyperglycemic Rats

Methanol Extract of Coleus amboinicus (Lour) Exhibited Antiproliferative Activity and Induced Programmed Cell Death in Colon Cancer Cell WiDr

In vivo antimalarial activities of russelia equisetiformis in plasmodium berghei infected mice

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