Investigation of resistin 420 and 62 gene polymorphism in patients with endometrial cancer

Özgör, Bahar Yüksel; Iyibozkurt, Cem; Baştu, Ercan; Berkman, Sinan; Yalçın, Önay; Çakmakoğlu, Bedia; Saygili, Halil

doi:10.1016/j.tjog.2018.11.030

Cited by 5 publications

(7 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This show us both increase in galanin and resistin increase risk of having EC but especially resistin increase may directly-not influenced by demographic parameters-increase risk of having EEC. This is same as study of Ozgor Yüksel B and et al [31]. They, first time, had demonstrated that Resistin 420 G > C and 62 G > A gene polymorphisms play a role in EC development.…”

Section: Discussionsupporting

confidence: 84%

Adipocyte related peptides — galanin and resistin in endometrioid type endometrium cancer

Avcıoğlu

Yüksel

2021

Ginekol Pol

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 84%

Adipocyte related peptides — galanin and resistin in endometrioid type endometrium cancer

Avcıoğlu

Yüksel

2021

Ginekol Pol

View full text Add to dashboard Cite

show abstract

“…Ozgor et al observed resistin gene RETN polymorphisms in endometrial cancer. 21 The data summarized above clearly support the hypothesis that there may exist an intrinsic interaction among the components of MS in patients with endometrial cancer.…”

Section: Wwox Expression Status and The Ossupporting

confidence: 60%

Expression of WW domain‐containing oxidoreductase and its clinical implication in endometrial adenocarcinoma patients with metabolic syndrome

Shen

Gao

Jiang

et al. 2021

Asia-Pac J Clncl Oncology

View full text Add to dashboard Cite

Aim: Metabolic syndrome (MS) is tightly associated with the oncogenesis and prognosis of endometrioid adenocarcinoma, but the underlying mechanism is unclear. Here, we studied the relation between the expression status of WW domain-containing oxidoreductase (WWOX) and the clinicopathological features of endometrioid adenocarcinoma patients with MS.Methods: Fifty-seven samples of endometrial adenocarcinoma were chosen for detection of expression level of WWOX. Overall survival (OS) time of these patients was analyzed by univariate and multivariate analysis. Survival analysis of patients with different WWOX expression levels from the Cancer Genome Atlas (TCGA) database was also performed. Results:The WWOX expression is significantly higher in MS group than that in non-MS group (36.4% vs 65.7%, P = .03). WWOX was closely related to MS (P = .03) and muscle invasion of tumor cells (P = .04), but age, tumor grade, status of lymphatic metastasis, and FIGO (International Federation of Gynecology and Obstetrics) stage were not significantly different between the two WWOX expression status. Univariate analysis revealed that lymphatic metastasis (P = .023) and lower stage (P = .006) are significantly associated with OS. Multivariate analysis demonstrated that stage was an independent prognostic factor for OS (hazard ratio = 0.197; 95% CI, 0.043-0.896). Downregulation of WWOX was statistically associated with OS in patients from TCGA database (P = .04). Conclusion:WWOX may play an important role in the progression of endometrial cancer with MS.

show abstract

“…Our results came in accordance with an earlier study which reported increased resistin level in breast cancer patients compared to controls. 19 Another study reported significant association of resistin with tumor and inflammatory markers, tumor size, cancer grade, tumor stage, lymph node invasion and decreased disease-free survival among females with breast cancer. 12 Resistin has been linked to increased risk of progression, angiogenesis, metastasis, and poor prognosis in various cancer models.…”

Section: Discussionmentioning

confidence: 99%

Impacts of RETN genetic polymorphism on breast cancer development in Beni-Suef females, Egypt

Farhan

Abougabal

Ramadan

et al. 2023

EJI

View full text Add to dashboard Cite

Breast cancer is the most common cancer among females with increasing incidence and death rates. Resistin is pro-inflammatory molecule which shares in diverse cellular signaling pathways. This study aimed to evaluate resistin and RETN rs3219175 gene polymorphism and their relevance to diagnostic susceptibility, prognostic value, and genetic risk among Egyptian female patients with breast cancer. Eighty female patients with breast cancer were recruited from the Oncology Department, Faculty of Medicine, Beni-Suef University. Breast cancer staging and grading were determined. Eighty age-matched normal females participated as controls. Quantitative determination of serum resistin was assayed by an enzyme-linked immunosorbent assay (ELISA). RETN rs3219175 gene polymorphism was determined by real time polymerase chain reaction (RT-PCR) TaqMan allelic discrimination assay. Serum resistin showed statistically significantly higher level among females with breast cancer when compared to controls (p <0.001). Resistin showed sensitivity of 80% and specificity of 67.5% at cut off value of 1.27 ng/mL for diagnosis of breast cancer (p =0.001). RETN rs3219175 gene polymorphism showed significantly higher frequency of AG, AA genotypes, and A allele among cases when compared to controls (p <0.001). No statistical difference was found in resistin level or RETN rs3219175 gene polymorphism regarding tumor characteristics including size, lymph nodes or distant metastasis. Resistin showed significantly higher level among carriers of AG followed by AA genotypes and among A allele (p <0.001). In conclusion, resistin could be proposed as a possible potential diagnostic marker and A allele of RETN rs3219175 gene might be suggested as a genetic risk allele among female patients with breast cancer.

show abstract

Investigation of resistin 420 and 62 gene polymorphism in patients with endometrial cancer

Cited by 5 publications

References 20 publications

Adipocyte related peptides — galanin and resistin in endometrioid type endometrium cancer

Adipocyte related peptides — galanin and resistin in endometrioid type endometrium cancer

Expression of WW domain‐containing oxidoreductase and its clinical implication in endometrial adenocarcinoma patients with metabolic syndrome

Impacts of RETN genetic polymorphism on breast cancer development in Beni-Suef females, Egypt

Contact Info

Product

Resources

About